Abstract: A method of treating age related behavorial problems in dogs is disclosed. The method involves administering adrafinil or a metabolite thereof to an animal in need of such treatment.

Abstract: Peptide nucleic acid (PNA) oligomers are conjugated to a ligand which is capable of binding to a cell surface receptor. The ligand facilitates cellular uptake of the PNA oligomer. Where the ligand is a peptide, the conjugate may be produced as a unitary molecule by first synthesizing the peptide ligand by solid phase or solution peptide synthesis, followed by synthesis of the PNA oligomer as an extension of the peptide ligand. The PNA oligomer base sequence is selected to hybridize to a target polynucleotide sequence by either triplex (dsDNA) or duplex (ssDNA; RNA) formation.

Abstract: A pipe elbow is provided having two parts, each part having an arcuate segment. The arcuate segment of the first part fits sealably into the arcuate segment of the second part. By severing a portion of the arcuate segment of the first part at an angle needed for a specific run of pipe and inserting it into the arcuate segment of the second part, the assembled elbow will conform to the required angle. In addition, a sloped shoulder on the outside of the first part fits in close proximity to the end of the second part to ensure a extension of the first part into the second part in order to meet industry standards for minimum overlap of mating parts. An angled end on the arcuate segment of the second part may also be provided.

Abstract: Methods of grading tumors and prognosticating survival rates of cancer patients by determination of p27 expression levels in tissues samples from tumors are provided.

Abstract: Methods of treating bladder cancer in a patient by administration of wildtype vaccinia virus are provided.

Abstract: A power wheelchair has a frame, a seat connected to the frame, a pair of drive wheels connected to the frame and rotatable about transverse axis below a portion of the seat supporting the wheelchair occupant's thighs and at least one ground-engaging idler wheel connected to the frame behind the drive wheels.

Abstract: A fuel tank for a motor vehicle, comprising a tank body with a smaller reservoir which is arranged therein and which is inserted into the tank body through a closable opening in the wall thereof, and joined thereto. The reservoir is deformable at least in portions of the wall defining same. After the reservoir has been at least partially inserted into the tank body, it undergoes a change in shape resulting in an increase in its volume within the tank body and a change in its cross-section such that the largest cross-section of the reservoir is larger than the cross-section of the opening of the wall in the tank body, that is available for insertion of the reservoir. The reservoir is defined at its ends by rigid components and the deformable wall portion of the reservoir is in the region between those components.

Abstract: The invention includes a method of phosphorylating a serine containing substrate by incubating the substrate with ATP and an enzyme that is hsRec2 or muRec2 or a derivative thereof. The natural substrates of the kinase activity of Rec2 are the cell cycle control proteins such as p53 and cyclin E. The over expression of Rec2 is known to cause cell-cycle arrest and apoptosis and the invention discloses that these effects are kinase mediated. Accordingly, the invention provides a method of assessing antagonists and agonists of Rec2, which antagonists and agonists would have pharmacological activity. The invention further discloses that there is specific binding between hsRec2 and at least three cell cycle control proteins: p53, PCNA and cdc2.

Abstract: A coated aerospace aluminum alloy part, such as a lipskin of a nacelle or a leading edge of a wing or tail, is disclosed which part is protected from corrosion due to severe environmental stresses, including high and low temperatures, and rain drop erosion, by a multilayer coating comprising a phosphate bonded metal containing basecoat and a resin based topcoat. A method of coating the part is disclosed.

Abstract: A remotely controllable and programmable power control unit for controlling and programming the state and power level, including special functions, of one or more electrical devices. The electrical device can be an electric lamp. The system includes a user-actuatable remote transmitter unit and a user-actuatable power control unit adapted to receive control signals from the remote transmitter unit. Both the remote transmitter unit and the power control unit include a power selection actuator for selecting a desired power level between a minimum power level and a maximum power level, and control switches for generating control signals representative of programmed power levels of one or more power scenes and special functions. In response to an input from a user, either directly or remotely, the one or more devices of the one or more power scenes can be controlled between an on or off state, to a desired programmed preset, or to a maximum power level.

Abstract: Apparatus and method accomplishes the precision pouring of a liquid from a vessel to a predetermined position with a controlled rate of flow. Independently controllable horizontal and vertical translation of the vessel is accomplished by using two rotational elements lying in substantially parallel planes, with the rotational axis of the second element passing through the first element, and having offset first and second axes of rotation. Independently controlled tilting of the vessel about a third axis of rotation that passes through the second element maintains a desired pour rate and aim point for the pour stream. The apparatus is particularly useful when the vessel and the receptacle that receives the liquid are inside a sealed chamber.

Abstract: A flow metering turbine comprises a tubular body through which flows the fluid to be measured. The tubular body houses an upstream spider and a downstream spider each formed by a hub and fixed vanes, bearing the hub in the tubular body. The mutually facing ends of the hubs have a cavity on the axis of the tubular body for receiving a support bearing and thrust bearing. A screw member formed by a hub bearing vanes and a shaft is located between the spiders, the ends of the shaft being located in the support bearings of the spiders and against the thrust bearings. At least one fluid duct runs through each spider, opening into the cavity in line with the support bearing and thrust bearing.

Abstract: A fluorescent dye composition for inclusion in a fluid for leak detection applications is provided which is responsive to a broad range of UVA, blue, and UVA-blue light sources. The composition comprises a mixture of a perylene dye, a naphthalimide dye, and a hydrocarbon-based fluid, wherein the combination of the perylene dye, the naphthalimide dye and the hydrocarbon-based fluid are miscible in the fluid. A fluorescent dye composition is also provided that is effective for all automotive working fluids, including heavy lubricants and transmission fluids, synthetic lubricants and internal combustion oils, refrigerants, liquid and gaseous fuels, and hydraulic fluids. A fluorescent dye composition is also provided containing only a combination of perylene dye and naphthalimide dye.

Abstract: A simulated shoulder is provided for purposes of creating a costume. The shoulder includes a platform having an upper and a lower surface, horizontally disposed support columns defining the periphery of the shoulder platform, and a head supporting structure attached to the upper surface for support of an inflatable bladder. The inflatable bladder is attached to the head supporting structure and simulates a head or supports a costume mask. An elongated support column extends downwardly from the platform. The support column is attached at one end to the platform and spaced apart a sufficient lateral distance so as to accommodate a wearer's head. There is also provided an adjustable flexible strap attached to the support columns to hold the structure to a wearer and for supporting the shoulder platform.

Abstract: The invention comprises an archery bow with a drawlock device adapted for use with an overdraw arrow rest. The device includes an elongated mounting bracket attached at its forward end to the bow's handle, and having intermediate its forward and rearward ends an overdraw arrow rest. The device further includes a draw tube attached to the rearward end of the mounting bracket and a draw rod in telescoping engagement with the draw tube. In a preferred embodiment, the draw tube can be attached to the mounting bracket at a selectable angle to align with the axis of the arrow between nock point and arrow rest after vertical adjustment to a tuned knocking point. The back end of the draw rod supports a bow string mechanical release. A latching device locks and holds the draw rod at a full draw position when the bow string is drawn beyond the full draw position.

Abstract: A method for and an apparatus for controlling and optimizing a xylene isomer separation and isomerization process, in which near infrared light of a wavelength ranging from 1,100 nm to 2,500 nm is transmitted through samples obtained at different stages of the process from raw materials flowing in the process by use of an analyzer system using optical fibers, thereby simultaneously measuring, in an on-line manner, xylene isomers and aromatic hydrocarbons containing 6 to 9 carbon atoms from those samples. Accordingly, it is possible to monitor the entire operation state of the process within 15 minutes in an on-line manner. Conventionally, 2 to 3 days are taken for the same monitoring.

Abstract: Substantially pure human cyclin-dependant kinase-like proteins PITALRE and PISSLRE and isolated proteinc complexes that comprise PITALRE or PISSLRE are disclosed. Isolated nucleic acid molecule that encodes PITALRE or PISSLRE, or a fragment thereof; recombinant expression vectors that comprise nucleic acid sequence that encode PITALRE or PISSLRE; and host cells that comprise such recombinant expression vectors are disclosed. Oligonucleotide molecules that consist of a nucleotide squence complimentary to a portion of the nucleotide sequence that encodes PITALRE or PISSLRE are disclosed. Antibodies which bind to epitopes on PITALRE or PISSLRE are disclosed. Nucleic acid molecules that comprise a nucleotide sequence that encodes phosphorylation deficient PITALRE or a phosphorylation deficient PISSLRE; recombinant vectors and pharmaceutical compositions that comprise such nucleotide sequences are also disclosed. Methods of identifying compounds which inhibit PITALRE activity are disclosed.

Abstract: A cabin interior assembly for an aircraft is disclosed, the aircraft having a primary airframe structure for supporting vibrating components. The cabin interior assembly includes a shell structure located within the airframe structure. The shell structure is formed from a plurality of axially spaced bell frames. Each bell frame is unitary and extends from one side of the cabin interior, across the ceiling and down to the other side. At least two longitudinal support members are attached to and extend between each adjacent pair of the bell frames. A plurality of panels are mounted to the shell structure with the edges of adjacent panels forming a butt joint as they overlap the bell frames and longitudinal support members. Isolators are disposed between the shell structure and the airframe structure. Each isolator includes a first component mounted to a lower end of a bell frame and a second component mounted on the airframe structure.

Abstract: The present invention provides antisense therapies useful for modulating smooth muscle cell proliferation. Methods of treating and preventing restenosis are also provided.

Abstract: The present invention provides a fiber optic link utilizing asymmetric homodyne modulation and balanced detection to achieve a very high dynamic range. The link uses a Mach Zehnder Modulator to generate a double-sideband suppressed-carrier signal from a laser light signal of a carrier frequency and a modulating signal at a modulating frequency. The laser light signal is phase shifted and injected into the double-sideband suppressed-carrier signal. Two signals are generated wherein the fundamental components are out-of-phase. The two signals are input to a balanced receiver wherein the one signal is subtracted from the other, resulting in the fundamental components adding, thereby providing an improved fundamental signal.