Patents Represented by Attorney Seth Jacobs

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  • Carbamate and carbazate ketolide antibiotics
    Patent number: 6664238
    Abstract: This invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof wherein X1, X2, R2, R15, R16 and R6 are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: December 16, 2003
    Assignee: Pfizer Inc.
    Inventors: Wei-Guo Su, Takushi Kaneko, Yong-Jin Wu
  • Method of synthesis of pyrrole amides
    Patent number: 6262272
    Abstract: A method for preparing pyrrole-carboxyamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloakane-diones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: July 17, 2001
    Assignee: Pfizer Inc
    Inventors: John Anthony Ragan, Teresa Woodall Makowski, David Jon Am Ende, Pamela Jane Clifford, Gregory Randall Young, Alyson Kay Conrad, Shane Allen Eisenbeis, George Joseph Quallich, Douglas John Meldrum Allen
  • 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
    Patent number: 6114361
    Abstract: The present invention relates to a compound of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are as defined above, to pharmaceutical compositions and methods of treatment.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: September 5, 2000
    Assignee: Pfizer Inc.
    Inventors: Ralph P. Robinson, Ellen R. Laird
  • Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
    Patent number: 6071935
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula I to said mammal.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: June 6, 2000
    Assignee: Pfizer Inc.
    Inventor: Joseph P. Lyssikatos
  • Pyrazolopyrimidines for treatment of CNS disorders
    Patent number: 6051578
    Abstract: This invention relates to the use of pyrazolopyrimidines and pyrrolopyrimidine of, respectively, the general formula ##STR1## wherein A, X, R.sup.3, R.sup.4 and R.sup.5 are as defined below, and the pharmaceutically acceptable salts of such compounds, to treat, prevent or inhibit certain neuronal and other disorders.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: April 18, 2000
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen