Patents Represented by Attorney, Agent or Law Firm Sherry M. Klowles, Esq.
  • Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
    Patent number: 6703396
    Abstract: A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (−)-2-hydroxymethyl-5-(5-flurocytosin-1-yl)-1,3-oxathiolane is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: March 9, 2004
    Assignee: Emory University
    Inventors: Dennis C. Liotta, Raymond F. Schinazi, Woo-Baeg Choi