Patents Represented by Attorney, Agent or Law Firm Simone L. Jones
  • Antibodies to viral encoded semaphorin protein receptor polypeptides
    Patent number: 6562949
    Abstract: The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for preparing VESPR polypeptides.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: May 13, 2003
    Assignee: Immunex Corporation
    Inventors: Melanie K. Spriggs, Michael R. Comeau, Robert F. DuBose, Richard S. Johnson
  • Methods and host cells for improved cell culture
    Patent number: 6413744
    Abstract: The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: July 2, 2002
    Assignee: Immunex Corporation
    Inventors: Arvia E. Morris, Pranhitha Reddy
  • Cytokine designated 4-1BB ligand antibodies and human receptor that binds thereto
    Patent number: 6355779
    Abstract: Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: March 12, 2002
    Assignee: Immunex Corporation
    Inventors: Raymond G. Goodwin, Craig A. Smith, Mark R. Alderson
  • Expression augmenting sequence elements (ease) for eukaryotic expression systems
    Patent number: 6312951
    Abstract: There are disclosed nucleotide sequences which can improve expression of recombinant proteins two to eight fold in stable cell pools when present in an expression vector.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: November 6, 2001
    Assignee: Immunex Corporation
    Inventors: Arvia E. Morris, Chi-Chang Lee, James N. Thomas
  • Expression augmenting sequence elements (ease) for eukaryotic expression systems
    Patent number: 6309841
    Abstract: There are disclosed nucleotide sequences which can improve expression of recombinant proteins two to eight fold in stable cell pools when present in an expression vector.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: October 30, 2001
    Assignee: Immunex Corporation
    Inventors: Arvia E. Morris, James N. Thomas
  • Recombinant cytokine designated LERK-6
    Patent number: 6268482
    Abstract: The invention is directed to LERK-6 as a purified and isolated protein, the DNA encoding the LERK-6, host cells transfected with cDNAs encoding LERK-6.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: July 31, 2001
    Assignee: Immunex Corporation
    Inventor: Douglas P. Cerretti
  • Assay kits for detection and methods of inhibiting IL-17 binding
    Patent number: 6197525
    Abstract: Isolated receptors for IL-17, DNA's encoding such receptors, pharmaceutical compositions made therefrom, detection assays and methods of inhibiting binding of the receports are disclosed. The isolated receptors can be used to regulate an immune response.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: March 6, 2001
    Assignee: Immunex Corporation
    Inventors: Zhengbin Yao, Melanie K. Spriggs, William C. Fanslow
  • Methods of treating graft rejection with the IL-17 receptor
    Patent number: 6191104
    Abstract: Isolated receptors for IL-17, DNA's encoding such receptors, pharmaceutical compositions made therefrom, and methods of treatment using the IL-17 receptors are disclosed. The isolated receptors can be used to regulate an immune response.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: February 20, 2001
    Assignee: Immunex Corporation
    Inventors: Melanie K. Spriggs, William C. Fanslow
  • Viral encoded semaphorin protein receptor polypeptides
    Patent number: 6187909
    Abstract: The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for preparing VESPR polypeptides.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: February 13, 2001
    Assignee: Immunex Corporation
    Inventors: Melanie K. Spriggs, Michael R. Comeau, Robert F. DuBose, Richard S. Johnson
  • Viral encoded semaphorin protein receptor DNA and polypeptides
    Patent number: 6174689
    Abstract: The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for preparing VESPR polypeptides.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: January 16, 2001
    Assignee: Immunex Corporation
    Inventors: Melanie K. Spriggs, Michael R. Comeau, Robert F. DuBose, Richard S. Johnson
  • Viral encoded semaphorin protein receptor DNA and polypeptides
    Patent number: 6130068
    Abstract: The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for preparing VESPR polypeptides.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: October 10, 2000
    Assignee: Immunex Corporation
    Inventors: Melanie K. Spriggs, Michael R. Comeau, Robert F. DuBose, Richard S. Johnson
  • Methods of treating immune and inflammatory response with IL-17 receptors
    Patent number: 6100235
    Abstract: Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, and methods of treatment using the IL-17 receptors are disclosed. The isolated receptors can be used to regulate an immune response.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: August 8, 2000
    Assignee: Immunex Corporation
    Inventors: Zhengbin Yao, Melanie K. Spriggs, William C. Fanslow
  • Receptor that binds IL-17
    Patent number: 6096305
    Abstract: Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: August 1, 2000
    Assignee: Immunex Corporation
    Inventors: Zhengbin Yao, Melanie K. Spriggs, William C. Fanslow
  • Method of regulating nitric oxide production or arthritis with soluble IL-17 receptor
    Patent number: 6083906
    Abstract: Methods for regulating levels of nitric oxide are disclosed. The methods utilize IL-17 receptors, which may be used in conjunction with inhibitor of IL-1 and/or TNF.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: July 4, 2000
    Assignee: Immunex Corporation
    Inventor: Anthony B. Troutt
  • Receptor that binds IL-17
    Patent number: 6072033
    Abstract: Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: June 6, 2000
    Assignee: Immunex Corporation
    Inventors: Zhengbin Yao, Melanie K. Spriggs, William C. Fanslow
  • Antibodies to the IL-17 receptor
    Patent number: 6072037
    Abstract: Isolated receptors for IL-17, DNA's encoding such receptors, antibodies to such receptors and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: June 6, 2000
    Assignee: Immunex Corporation
    Inventors: Zhengbin Yao, Melanie K. Spriggs, William C. Fanslow