Patents Represented by Attorney Stacey R. Sias

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  • Oligonucleotides and kits for detection of HTLVI and HTLVII viruses by hybridization
    Patent number: 5079351
    Abstract: The presence or absence of a nucleic acid sequence of an isolate of HTLVI and/or HTLVII in a sample containing one or more nucleic acids and suspected of containing such sequence can be detected by amplifying the sequence using primers to form extension products as templates and detecting the amplified product if it is present. This may be accomplished by adding a labeled hydridization probe to the amplified product, either free in solution or after immobilization on a solid support.
    Type: Grant
    Filed: November 26, 1986
    Date of Patent: January 7, 1992
    Assignee: Cetus Corporation
    Inventors: John J. Sninsky, Shirley Y. Kwok, Bernard Poiesz
  • Methods for DNA sequencing with thermus aquaticus DNA polymerase
    Patent number: 5075216
    Abstract: Dideoxynucleotide DNA sequencing methods can be dramatically improved by utilizing the DNA polymerase from Thermus aquaticus to catalyze the primer extension reactions.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: December 24, 1991
    Assignee: Cetus Corporation
    Inventors: Michael A. Innis, Kenneth B. Myambo, David H. Gelfand, Mary Ann D. Brow
  • Chimeric messenger RNA detection methods
    Patent number: 5057410
    Abstract: The invention provides highly sensitive methods for detecting specific sequences contained in chimeric mRNA. The mRNA sequences are reverse transcribed into complementary DNA (cDNA), amplified by the Polymerase Chain Reaction, and detected by hybridization with a labeled sequence specific oligonucleotide probe. The method is particularly valuable for the detection of chimeric mRNAs experessed by activated oncogenes that result from aberrant genetic rearragements such as chromosomal translocations.
    Type: Grant
    Filed: August 5, 1988
    Date of Patent: October 15, 1991
    Assignee: Cetus Corporation
    Inventors: Ernest S. Kawasaki, Francis P. McCormick, Owen O. Witto
  • Detection of AIDS associated virus by polymerase chain reaction
    Patent number: 5008182
    Abstract: The presence or absence of a nucleic acid sequence associated with AIDS in a sample containing one or more nucleic acids and suspected of containing such sequence can be detected by amplifying the sequence using primers to form extension products as templates and detecting the amplified product if it is present. This may be accomplished by adding a labeled hybridization probe to the amplified product either free in solution or after immobilization on a solid support.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: April 16, 1991
    Assignee: Cetus Corporation
    Inventors: John J. Sninsky, Shirley Y. Kwok, David H. Mack