Patents Represented by Attorney, Agent or Law Firm Stephen G. Kalinchak
  • Substituted pyridine derivatives
    Patent number: 8299071
    Abstract: The present invention relates to pyridine derivatives of the general formula (I) and their use as openers of the KCNQ family potassium ion channels for the treatment of CNS disorders.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: October 30, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornoe, Nikolay Khanzhin, Mario Rottlander, William Patrick Watson, Daniel Rodriguez Greve
  • Substituted thiomorpholine derivatives
    Patent number: 8299075
    Abstract: The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: October 30, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornoe, Mario Rottlander, Nikolay Khanzhin, William Patrick Watson, Andreas Ritzen
  • Isoquinolinone derivatives as NK3 antagonists
    Patent number: 8242134
    Abstract: The invention relates to compounds useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: August 14, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Nikolay Khanzhin, Karsten Juhl, Soren Moller Nielsen, Klaus Baek Simonsen
  • Processes for 4-((1R,35)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine or a salt thereof
    Patent number: 8227607
    Abstract: Methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and salts thereof are described.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: July 24, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngsø, Sherry Lynn Collier
  • Pyridone derivatives as NK3 antagonists
    Patent number: 8207347
    Abstract: The present invention relates to compounds useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: June 26, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Nikolay Khanzhin, Søren Møller Nielsen, Karsten Juhl, Lars Kyhn Rasmussen
  • Adamantyl diamide derivatives and uses of same
    Patent number: 8198275
    Abstract: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: June 12, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Hermogenes N. Jimenez, Guiying Li, Dario Doller, Michel Grenon, Andrew D. White, Gil Ma, Maojun Guo
  • Isoquinolinone derivatives as NK3 antagonists
    Patent number: 8173639
    Abstract: Isoquinolone derivatives of the general formula are provided. The compounds are NK3 antagonists and useful for the treatment of e.g. psychosis and schizophrenia.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: May 8, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Klaus Baek Simonsen, Jan Kehler, Karsten Juhl, Nikolay Khanzhin, Soren Moller Nielsen
  • Malonate salt of 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and uses of same
    Patent number: 8076342
    Abstract: 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen malonate salt and pharmaceutical comprising and uses of the same, including for the treatment of schizophrenia and other psychotic disorders are described.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: December 13, 2011
    Inventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngso
  • Phenolic and catecholic amines and prodrugs thereof
    Patent number: 8067410
    Abstract: The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to their use in radiolabeled form as PET- or SPECT ligands.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: November 29, 2011
    Assignee: H. Lundbeck A/S
    Inventors: Ask Puschl, Morten Jorgensen, Benny Bang-Andersen
  • Modulation of activity of neurotrophins
    Patent number: 8066997
    Abstract: The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4 (NT-4), in an animal and methods for treatment of a disease or disorder in an individual by modulation of neurotrophin activity. The modulation is carried out by interfering with binding between a neurotrophin and a receptor of the Vps10p-domain receptor family or modulating the expression of a receptor of the Vps10p-domain receptor family. Methods for screening for agents capable of modulating neurotrophin activity and agents selected using these screening methods are also disclosed, as are methods for determining the effect of an agent on one or more neurotrophins in cells. The present invention also pertains to methods for modulating the transport of one or more neurotrophins.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: November 29, 2011
    Inventors: Anders Nykjaer, Claus Munck Petersen
  • Method for the separation of intermediates which may be used for the preparation of escitalopram
    Patent number: 8067640
    Abstract: The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: November 29, 2011
    Assignee: H. Lundbeck A/S
    Inventors: Naoki Taoka, Takahisa Kato, Shogo Yamamoto, Takashi Yoshida, Toshihiro Takeda, Yasuyoshi Ueda, Hans Petersen, Robert Dancer, Haleh Ahmadian, Lars O. Lyngso
  • Method for manufacture of escitalopram
    Patent number: 8022232
    Abstract: This patent discloses a method for resolution of 4-[4-(dimethylamino)-1-(4?-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallizing 4-[4-(dimethylamino)-1-(4?-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a salt with the (+)-(S,S)- or (?)-(R,R)-enantiomer of O,O?-di-p-toluoyl-tartaric acid in a solvent system comprising 1-propanol, ethanol or acetonitrile.
    Type: Grant
    Filed: September 2, 2008
    Date of Patent: September 20, 2011
    Assignee: H. Lundbeck A/S
    Inventors: Carla De Faveri, Florian Anton Martin Huber, Robert Dancer
  • Adamantyl diamide derivatives and uses of same
    Patent number: 7947680
    Abstract: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: May 24, 2011
    Assignee: H. Lundbeck A/S
    Inventors: Hermogenes N. Jimenez, Guiying Li, Dario Doller, Michel Grenon, Andrew D. White, Gil Ma, Maojun Guo
  • Cyclopropyl derivatives as NK3 receptor antagonists
    Patent number: 7834008
    Abstract: The present invention relates to cyclopropyl derivatives of formula (I) and salt thereof. These compounds are NK3 receptor antagonists and may therefore be useful for treatment of diseases where the NK3 receptor is implicated, e.g. psychotic disorders.
    Type: Grant
    Filed: August 13, 2004
    Date of Patent: November 16, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Jan Kehler, Tore Hansen, Anders Poulsen, Berith Bjørnholm, Thomas Ruhland, Morten Bang Nørgaard, Søren Møller Nielsen
  • -1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
    Patent number: 7772240
    Abstract: A compound 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-2,2-dimethylpiperazine and salts thereof, pharmaceutical compositions comprising the compound and salts, and medical use thereof, including for treatment of schizophrenia and other psychotic disorders.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: August 10, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Benny Bang-Andersen, Klaus Peter Bogeso, Henrik Svane, Lars Ole Lyngso, Allan Carsten Dahl, Mark Howells, Klaus Gjervig Jensen, Tomas Mow
  • Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament
    Patent number: 7767683
    Abstract: 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate, pharmaceutical compositions containing the salt and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: August 3, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngso, Sherry Lynn Collier
  • Uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRIS
    Patent number: 7737170
    Abstract: The present invention relates to uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I): in the treatment of affective disorders.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: June 15, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Jan Kehler, Karsten Juhl, Jimmy Sejberg, Morten Bang Nørgaard
  • Uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRIS
    Patent number: 7737171
    Abstract: The present invention relates to uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I): in the treatment of affective disorders.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: June 15, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Jan Kehler, Karsten Juhl, Jimmy Sejberg, Morten Bang Nørgaard
  • 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
    Patent number: 7732463
    Abstract: The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: June 8, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Ask Puschl, Benny Bang-Andersen, Morten Jorgensen, Thomas Ruhland, Tine B. Stensbol
  • Substituted pyrimidine derivatives
    Patent number: 7683058
    Abstract: The present invention relates to pyrimidine derivatives of the general formula I or salts thereof and their use.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: March 23, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Nikolay Khanzhin, Daniel Rodriguez Greve, Mario Rottländer