Abstract: A protein from Group B Streptococcus is shown to be an outer surface protein and is a useful target for antimicrobial therapy.
Type:
Grant
Filed:
September 17, 2004
Date of Patent:
September 22, 2009
Assignee:
Emergent Product Development UK Limited
Inventors:
Martin John Glenton Hughes, Joseph David Santangelo, Jonathan Douglas Lane, Robert Feldman, Joanne Christine Moore, Richard James Dobson, Paul Everest, Gordon Dougan, Rebecca Kerry Wilson
Abstract: A hydraulic transmission (21) has an electric actuator (86) for changing its output/input rotation speed ratio. A controller (90) of the actuator memorizes a command current value to the actuator supposing that load is not applied on the hydraulic transmission, and calculates a value of load applied on the hydraulic transmission by calculating a difference between an actual command current value to the actuator and the memorized command current value. A command current value is compensated based on the value of load, and the actuator receives feedback to be controlled. A vehicle may have a differential mechanism (10), which combines rotation powers on input side and output side of the hydraulic transmission. A detector (82) detects rotation speed of a main speed change output shaft (27) serving as an output shaft of the differential mechanism.
Abstract: Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R.sup.1 -R.sup.4, R.sup.6 -R.sup.9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.
Type:
Grant
Filed:
March 16, 1999
Date of Patent:
October 17, 2000
Assignee:
3-Dimensional Pharmaceuticals, Inc.
Inventors:
Tianbao Lu, Bruce E. Tomczuk, Carl R. Illig, Richard M. Soll