Patents Represented by Attorney Steven R. Crowley

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  • Flavoring systems for pharmaceutical compositions and methods of making such compositions
    Patent number: 6911214
    Abstract: A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: June 28, 2005
    Assignee: Abbott Laboratories
    Inventors: Laman Alani, Donald P. Gauwitz, Dilip Kaul, John M. Lipari, Soumojeet Ghosh, Kennan C. Marsh, Richard H. Whelan, Vanik D. Petrossian
  • Polymorph of a pharmaceutical
    Patent number: 6894171
    Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: May 17, 2005
    Assignee: Abbott Laboratories
    Inventors: John F. Bauer, Azita Saleki-Gerhardt
  • Method for improving pharmacokinetics
    Patent number: 6703403
    Abstract: A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: March 9, 2004
    Assignee: Abbott Laboratories
    Inventors: Daniel W. Norbeck, Dale J. Kempf, John M. Leonard, Richard J. Bertz
  • Retroviral protease inhibiting compounds
    Patent number: 6667404
    Abstract: A retroviral protease inhibiting compound of the formula: is disclosed.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: December 23, 2003
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing Leung Sham, Chen Zhao, Thomas J. Sowin, Daniel S. Reno, Anthony R. Haight
  • Crystalline pharmaceutical
    Patent number: 6608198
    Abstract: New crystalline forms of lopinavir are disclosed.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: August 19, 2003
    Assignee: Abbott Laboratories
    Inventors: Daniel A. Dickman, Sanjay Chemburkar, James J. Fort, Rodger F. Henry, David Lechuga-Ballesteros, Yuping Niu, William Porter
  • Retroviral protease inhibiting compounds
    Patent number: 6531610
    Abstract: A retroviral protease inhibiting compound of the formula: is disclosed.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: March 11, 2003
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck
  • Pharmaceutical composition
    Patent number: 6521651
    Abstract: A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HIV protease inhibitor and, optionally, (b) a surfactant. The composition can optionally be encapsulated in either hard gelatin capsules or soft elastic capsules (SEC).
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: February 18, 2003
    Assignee: Abbott Laboratories
    Inventors: John Lipari, Laman A. Al-Razzak, Soumojeet Ghosh, Rong Gao, Dilip Kaul
  • Retroviral protease inhibiting compounds
    Patent number: 6472529
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: October 29, 2002
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Pharmaceutical composition
    Patent number: 6458818
    Abstract: A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HIV protease inhibitor and, optionally, (b) a surfactant. The composition can optionally be encapsulated in either hard gelatin capsules or soft elastic capsules (SEC).
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: October 1, 2002
    Assignee: Abbott Laboratories
    Inventors: John Lipari, Laman A. Al-Razzak, Soumojeet Ghosh, Rong Gao, Dilip Kaul
  • Processes and intermediates for preparing retroviral protease inhibitors
    Patent number: 6372905
    Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: April 16, 2002
    Assignee: Abbott Laboratories
    Inventors: Sanjay R. Chemburkar, Ketan M. Patel, Harry O. Spiwek
  • Retroviral protease inhibiting compounds
    Patent number: 6313296
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: November 6, 2001
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Retroviral protease inhibiting compounds
    Patent number: 6284767
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: September 4, 2001
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Dale J. Kempf, Xiaoqi Chen, David A. Betebenner, Thomas R. Herrin, Gondi N. Kumar, John M. Lipari, Laman Alani, Soumojeet Ghosh, Rong R. Gao, Dilip Kaul
  • Retroviral protease inhibiting compounds
    Patent number: 6251906
    Abstract: The present invention discloses novel compounds, compositions, and methods for inhibiting retroviral proteases and in particular for inhibiting human immunodeficiency virus (HIV) protease. The present invention also relates to compositions and methods for treating a retroviral infection and in particular an HIV infection, and to processes for making such compounds and synthetic intermediates employed in these processes.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: June 26, 2001
    Assignee: Abbott Laboratories
    Inventors: Xiaoqi Chen, Dale J. Kempf, Daniel W. Norbeck
  • Pharmaceutical composition
    Patent number: 6232333
    Abstract: A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HIV protease inhibitor and, optionally, (b) a surfactant. The composition can optionally be encapsulated in either hard gelatin capsules or soft elastic capsules (SEC).
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: May 15, 2001
    Assignee: Abbott Laboratories
    Inventors: John Lipari, Laman A. Al-Razzak, Soumojeet Ghosh, Rong Gao, Dilip Kaul
  • Process for the preparation of a disubstituted thiazole
    Patent number: 6160122
    Abstract: A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: December 12, 2000
    Assignee: Abbott Laboratories
    Inventors: Patricia A. Oliver, Arthur J. Cooper, John E. Lallaman, Denton C. Langridge, Jieh-Heh J. Tien
  • Retroviral protease inhibiting compounds
    Patent number: 6150530
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: November 21, 2000
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing Leung Sham, Chen Zhao, Thomas J. Sowin, Daniel S. Reno, Anthony R. Haight
  • Method for improving pharmacokinetics
    Patent number: 6037157
    Abstract: A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: March 14, 2000
    Assignee: Abbott Laboratories
    Inventors: Daniel W. Norbeck, Dale J. Kempf, John M. Leonard, Richard J. Bertz
  • Process for the preparation of an activated amino acid
    Patent number: 6022989
    Abstract: A process is disclosed for the preparation of an N-acylated activated derivative of an amino acid or a salt thereof.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: February 8, 2000
    Assignee: Abbott Laboratories
    Inventors: Patricia A. Oliver, Arthur J. Cooper, Joseph B. Paterson, Jr., Denton C. Langridge, Jieh-Heh J. Tien
  • Retroviral protease inhibiting compounds
    Patent number: 6017928
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: January 25, 2000
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Hing Leung Sham, Chen Zhao, Thomas J. Sowin, Daniel S. Reno, Anthony R. Haight
  • Retroviral protease inhibiting compounds
    Patent number: 5990135
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: November 23, 1999
    Assignee: Abbott Laboratories
    Inventors: Daniel W. Norbeck, Hing Leung Sham, Dale J. Kempf, Chen Zhao