Abstract: The present invention provides compounds of the formula: wherein R1 is C3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or more fluorine atoms, or C3-6 cycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and R2 is phenyl optionally substituted by one or more fluorine atoms, to pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such compounds.
Type:
Grant
Filed:
October 3, 2003
Date of Patent:
May 6, 2008
Assignee:
Pfizer, Inc.
Inventors:
Manoussos Perros, David Anthony Price, Blanda Luzia Christa Stammen, Anthony Wood
Abstract: The present invention relates to a compound of the formula 1 wherein A and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Type:
Grant
Filed:
May 6, 2005
Date of Patent:
April 24, 2007
Assignee:
Pfizer Inc.
Inventors:
John Charles Kath, Michael Joseph Luzzio
Abstract: The present invention relates to a method of making a compound of the formula wherein X1, X2 and R3—R4 are as defined herein. The method includes reacting a compound of the formula with an amine of formula 3 (HNR3R4) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the treatment of abnormal cell growth, such as cancer, in mammals.
Type:
Grant
Filed:
August 27, 2004
Date of Patent:
October 17, 2006
Assignee:
Pfizer Inc
Inventors:
John Charles Kath, Daniel Tyler Richter, Michael Joseph Luzzio