Patents Represented by Attorney Stuart E. Krieger
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Patent number: 5958253Abstract: A device for separating components, such as fibrin I from blood, by way of centrifugation about a central axis of rotation comprises a first annular chamber defined by an outer cylindrical wall and an inner cylindrical wall, both walls being concentrically accommodated about the axis of rotation, and by a top wall and a bottom wall, where the top wall or the bottom wall is formed by a piston body displaceable within the first chamber. The device comprises furthermore a second chamber communicating with said first chamber through a first conduit and being defined by an outer cylindrical wall concentrically accommodated about the axis of rotation, said bottom wall of the first chamber, and another bottom wall. The second chamber is adapted to be placed below the first chamber during the centrifugation.Type: GrantFiled: November 6, 1997Date of Patent: September 28, 1999Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5955026Abstract: An apparatus for separating a blood component, e.g., fibrin monomer, from blood or plasma ?comprises! includes a container ?(110)! with a reaction chamber for receiving the plasma, where ?said! the reaction chamber is defined by an outer wall and ?comprises! includes means for supplying ?said! the reaction chamber with an agent for converting the fibrinogen content of the plasma into a non-cross-linked fibrin polymer. The apparatus ?comprises furthermore! also includes a device for centrifuging the reaction chamber with the plasma and ?said! the agent to a degree sufficient for separating the non-cross-linked fibrin polymer from the plasma, for depositing ?said! the polymer on the outer wall of the reaction chamber, and for expelling the remaining plasma from the reaction chamber. The container ?(110) comprises! includes means for supplying the reaction chamber with a solvent for dissolving ?said! the non-cross-linked fibrin polymer.Type: GrantFiled: January 8, 1998Date of Patent: September 21, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Niels Erik Holm, Glenn A. Jorgensen
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Patent number: 5938176Abstract: An aim of the invention is to provide a simple and effective one-piece tap which can be readily and economically manufactured. A tap for a liquid container is made from natural or synthetic rubber or a resilient plastics material. It has a base portion 10 having an orifice 12 which serves as a liquid inlet therein, the base portion embodying a liquid exit means 14. It also has a resilient deformable closure portion 20, the closure portion being constructed to make a resilient snap-on connection with the periphery of the base portion, the closure portion being manipulatable and having a centrally located plug 22 extending towards the base portion. This plug can obturate orifice 12 thereby closing the liquid inlet.Type: GrantFiled: May 1, 1996Date of Patent: August 17, 1999Assignee: Bristol-Myers Squibb CompanyInventor: Malcolm Ian Falconer
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Patent number: 5935432Abstract: A device for separating components, such as fibrin I from blood, by way of centrifugation about a central axis of rotation comprises a first annular chamber defined by an outer cylindrical wall and an inner cylindrical wall, both walls being concentrically accommodated about the axis of rotation, and by a top wall and a bottom wall, where the top wall or the bottom wall is formed by a piston body displaceable within the first chamber. The device comprises furthermore a second chamber communicating with said first chamber through a first conduit and being defined by an outer cylindrical wall concentrically accommodated about the axis of rotation, said bottom wall of the first chamber, and another bottom wall. The second chamber is adapted to be placed below the first chamber during the centrifugation.Type: GrantFiled: November 6, 1997Date of Patent: August 10, 1999Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5928202Abstract: The hollow cylindrical syringe body has a channel of uniform diameter. A fluid port is situated at one end. The other end defines a funnel-like opening with a diameter greater than that of the channel. A piston is moved along the channel by the end of a push rod which is received through the channel opening. A ball on the push rod lodges in a socket in the piston as the rod pushes the piston toward the port. The socket is formed of resilient fingers which are held by the channel wall in position to retain the ball in the socket, such that the piston can be moved along the channel to load the syringe. When the socket aligns with the funnel-like opening of the channel, the socket fingers spread apart to release the ball from the socket, permitting the push rod to be removed from the loaded syringe.Type: GrantFiled: October 23, 1998Date of Patent: July 27, 1999Assignee: Bristol-Myers Sauibb CompanyInventor: Steven Linnebjerg
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Patent number: 5922025Abstract: A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.Type: GrantFiled: October 3, 1995Date of Patent: July 13, 1999Assignee: Bristol-Myers Squibb CompanyInventor: William G. Hubbard
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Patent number: 5902295Abstract: An ostomy coupling has first and second coupling members. These can be held together by a springy flexible split locking ring. A plurality of tabs, arranged, e.g., symetrically, on the limbs of the locking ring can be withdrawn generally radially outwardly by movement of the locking ring to permit separation of the two coupling members. The movement of the locking ring which causes withdrawal of the tabs may be a vertically upward movement of the ring, or a vertically downward movement. The movement of the locking ring which causes withdrawal of the tabs alternatively may be a deformation of the ring in opposed horizontal directions. Preferably, however, the movement of the locking ring which causes a withdrawal of the tabs is a rotational movement relative to the second coupling member.Type: GrantFiled: April 12, 1996Date of Patent: May 11, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Peter L. Steer, Keith G. M. Hollands
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Patent number: 5873810Abstract: An apparatus for centrifuging and furthermore automatically handling a container (10) for separating a component, such as fibrin monomer, from plasma, where the container (10) comprises a cylindrical member (11) with a lower rim as well as a piston member (12) with a tubular piston rod (12) projecting upwardly from the upper end of the cylindrical member (11). The apparatus comprises a supporting turntable (1) with a first gripping member (27) releasably gripping the lower rim of the cylindrical member (11) when the container is placed thereon, the supporting turntable being connected to a first activator (5) for rotating the turntable (1) with the container (10) about the central axis thereof. Furthermore, the apparatus comprises a rotatably journalled piston activating mechanism adapted to activate the piston (12) by way of a second activator (21) and provided with a second gripping member (13) for releasably gripping the piston rod (12).Type: GrantFiled: December 6, 1996Date of Patent: February 23, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Niels Erik Holm, Raymond Carr, Niels Hvid, Louis Andersen, Jesper J.o slashed.rgensen
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Patent number: 5860959Abstract: The malodours of an ostomy bag are reduced by including therein an article including a hygroscopic matrix and additive. The matrix is selected from polyethylene glycol, polypropylene glycol and glycerol. The additive is selected from food preservatives, fragrances, disinfectants, and odor absorbers.Type: GrantFiled: February 13, 1997Date of Patent: January 19, 1999Assignee: Bristol-Meyers Squibb CompanyInventor: John A. Gent
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Patent number: 5849178Abstract: An apparatus is provided for centrifuging and further automatically handling a container (110) for separating a component, such as fibrin monomer, from blood. The container (110) comprises a cylindrical member (27) and a piston displaceable in said cylindrical member, said piston comprising a tubular piston rod (8) extending through a top wall (73). The piston divides the cylindrical member (27) into a first chamber (70) positioned above said piston between said piston and the top wall (73), and a second chamber positioned below said piston. The top wall (73) of the container comprises an extension (90) defining a circumferential slit surrounding the outer side of the piston rod (8), whereby one end of said slit communicates in the axial direction with the first chamber. In addition, the first chamber communicates through a plurality of channels with the second chamber.Type: GrantFiled: January 8, 1998Date of Patent: December 15, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Niels Erik Holm, Glenn A. Jorgensen
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Patent number: 5843053Abstract: An ostomy coupling has a first coupling member and a second coupling member. These are mutually interengageable and surround a region which includes a stomal orifice. A springy resilient ring encircles the two coupling members and has a handle member which can be manipulated to cause the ring to be deformed such that radially-inwardly extending tabs on the ring are shifted between respective first positions in which the ring is undeformed and the tabs lock the two coupling members together and respective second positions in which the ring is deformed in such a way as to shift the tabs radially outwardly to positions where they permit separation of the two coupling parts. The ring has a portion which joins the ends of two limbs of the ring, said portion being readily deformable and optionally sufficiently elastic such that the limb ends are pulled towards each other by the elasticity of said portion.Type: GrantFiled: October 4, 1996Date of Patent: December 1, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Peter L. Steer
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Patent number: 5830352Abstract: A reagent delivery system comprises an axial hub passing through the center of two equal-diameter, spaced apart discs, wherein the hub and discs are positioned in a sleeve such that an annular reagent chamber is provided. When the sleeve is moved in either an up or down axial direction the so-formed chamber is opened and the reagent is released. Such a regent delivery system is particularly useful in a centrifuge for concentrating or preparing blood products.Type: GrantFiled: December 1, 1995Date of Patent: November 3, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5830200Abstract: It would be desirable to have improved designs of ostomy couplings which embody a springy or resilient split ring as a locking ring.In an ostomy coupling, first and second coupling members 50, 60 are held together by a springy flexible split locking ring 70. A plurality of tabs 71 symmetrically arranged on each limb of the locking ring 70, can be withdrawn generally radially outwardly by an upward pull on the locking ring to permit separation of the two coupling members. The ring 70 is generally circular in its unstressed condition.Type: GrantFiled: April 12, 1996Date of Patent: November 3, 1998Assignee: E. R. Squibb & Sons, Inc.Inventors: Peter L. Steer, Keith G. M. Hollands, Graham Emery Steer, Ronald A. Plass, Howard Barratt
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Patent number: 5824230Abstract: A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added.Type: GrantFiled: November 7, 1996Date of Patent: October 20, 1998Assignee: E.R. Squibb & Sons, Inc.Inventors: Niels Erik Holm, Peter A. D. Edwardson
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Patent number: 5801220Abstract: A rapid disintegrating and dispersing composition for thickening liquid waste into a thixotropic gel comprises a polymeric acrylic resin and a colloid-forming mixture of microcrystalline cellulose and sodium carboxymethylcellulose. Additional ingredients preferably used in making a tableted form of the composition include microcrystalline cellulose per se, polyvinylpolypyrrolidone, magnesium stearate and amorphous silica. The tablet is placed in suitable containment means such as a containment bag. The thixotropic properties of the composition enable the gelled waste to be restored to a liquid when small amounts of hand pressure are applied to the waste containment bag, thereby providing a convenient and simple means for disposal.Type: GrantFiled: November 1, 1995Date of Patent: September 1, 1998Assignee: E.R. Squibb & Sons, Inc.Inventors: Divyakant S. Desai, Ajit B. Thakur
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Patent number: 5795489Abstract: A method and a device for separating a component, such as fibrin I from blood, by centrifugation. The method involves feeding of blood admixed an anticlotter to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall, where the top wall or the bottom wall is formed by a piston body displaceable within the first chamber. The method involves furthermore a centrifugation of the device about the said common axis followed by a resulting liquid fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall, which extends coaxially with said common axis.Type: GrantFiled: November 8, 1996Date of Patent: August 18, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5792344Abstract: In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical walls defining a longitudinal axis and a top wall and further a piston body constituting a bottom wall of the housing. The piston body defines together with the outer cylindrical wall, the inner cylindrical wall and the top wall, an annular chamber for receiving the liquid sample. The piston body is displaceable within the annular chamber for draining a phase portion separated from the liquid sample through a drain conduit means communicating with the annular chamber. The phase separation chamber further comprises a reaction chamber to which the phase portions exposed from the annular chamber is processed.Type: GrantFiled: October 31, 1996Date of Patent: August 11, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5776336Abstract: In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical walls defining a longitudinal axis and a top wall and further a piston body constituting a bottom wall of the housing. The piston body defines together with the outer cylindrical wall, the inner cylindrical wall and the top wall, an annular chamber for receiving the liquid sample. The piston body is displaceable within the annular chamber for draining a phase portion separated from the liquid sample through a drain conduit means communicating with the annular chamber. The phase separation chamber further comprises a reaction chamber to which the phase portions exposed from the annular chamber is processed.Type: GrantFiled: October 31, 1996Date of Patent: July 7, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5738784Abstract: A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added.Type: GrantFiled: December 1, 1995Date of Patent: April 14, 1998Assignee: E.R. Squibb & Sons, Inc.Inventors: Niels Erik Holm, Peter A. D. Edwardson
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Patent number: D396289Type: GrantFiled: April 28, 1997Date of Patent: July 21, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Steve McGugan