Patents Represented by Attorney Stuart L. Melton
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Patent number: 4424213Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.Type: GrantFiled: November 2, 1981Date of Patent: January 3, 1984Assignee: SDS Biotech CorporationInventors: Thomas A. Magee, Robert D. Battershell, Lawrence E. Limpel, Andrew W. Ho, Arthur W. Friedman, H. Glenn Corkins, William W. Brand, Russell Buchman, Louis Storace, Edmond R. Osgood
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Patent number: 4310551Abstract: Substituted 1,2,4-triazines, compositions thereof and methods of using same are described. The compounds of the invention exhibit a wide range of pharmacological activity including anti-inflammatory, analgesic, anti-pyretic, hypotensive and central nervous system effects.Type: GrantFiled: November 14, 1980Date of Patent: January 12, 1982Assignee: Diamond Shamrock CorporationInventors: James M. Gullo, William P. Heilman, Robert J. Wayner, Robert E. Moser
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Patent number: 4286091Abstract: Valuable pyridazinone intermediates to pharmaceutically useful compounds can be prepared in surprisingly high yields by the reaction of the corresponding monohydrazone with diketene, preferably in the presence of a basic catalyst. In an especially preferred embodiment, p,p'-dichlorobenzil monohydrazone and diketene are reacted in a xylene solvent in the presence of triethylamine to afford 4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one, which can then be reacted with ethylene carbonate in the presence of potassium carbonate to afford the antihypertensive agent, 4-acetyl-5,6-bis(p-chlorophenyl)-2-(2'-hydroxyethyl)-2H-pyridazine-3-one.Type: GrantFiled: May 19, 1980Date of Patent: August 25, 1981Assignee: Diamond Shamrock CorporationInventors: Russell M. Bimber, Russell Buchman, Michael F. DePompei, Larry J. Powers
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Patent number: 4281125Abstract: Valuable pyridazinone intermediates to pharmaceutically useful compounds can be prepared in surprisingly high yields by the quinoline catalyzed reaction of the corresponding monohydrazone with an appropriately substituted acetic acid ester. In an especially preferred embodiment, p,p'-dichlorobenzil monohydrazone and methyl acetoacetate are reacted in a xylene solvent in the presence of quinoline to afford 4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one, which can then be reacted with ethylene carbonate in the presence of potassium carbonate to afford the antihypertensive agent, 4-acetyl-5,6-bis(p-chlorophenyl)-2-(2'-hydroxyethyl)-2H-pyridazin-3-one.Type: GrantFiled: May 15, 1980Date of Patent: July 28, 1981Assignee: Diamond Shamrock CorporationInventors: Michael F. DePompei, Alex Hlynsky
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Patent number: 4258715Abstract: Improved shaped polymeric articles, including ostomy seals, are obtained by radiation crosslinking an acrylamide polymer composition comprising a water-soluble acrylamide polymer plasticized with a quantity of a water-miscible polyol (containing water) that provides a soft, flexible and elastomeric composition.Type: GrantFiled: December 8, 1978Date of Patent: March 31, 1981Assignee: Diamond Shamrock CorporationInventor: Paul H. Goble
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Patent number: 4254008Abstract: An improved ostomy seal is provided by a crosslinked composition comprising a water-soluble acrylamide polymer, a plasticizing quantity of a water-miscible polyol (containing water) that provides an elastomeric gel, and a crosslinking polyaldehyde.Type: GrantFiled: September 13, 1979Date of Patent: March 3, 1981Assignee: Diamond Shamrock CorporationInventor: George Krsek
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Patent number: 4251527Abstract: Substituted 1,2,4-triazines, compositions thereof and methods of using same are described. The compounds of the invention exhibit a wide range of pharmacological activity including anti-inflammatory, analgesic, anti-pyretic, hypotensive and central nervous system effects.Type: GrantFiled: March 19, 1979Date of Patent: February 17, 1981Assignee: Diamond Shamrock CorporationInventors: James M. Gullo, William P. Heilman, Robert J. Wayner, Robert E. Moser
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Patent number: 4238490Abstract: Compounds of the formula ##STR1## are useful antihypertensive agents.Type: GrantFiled: February 12, 1979Date of Patent: December 9, 1980Assignee: Diamond Shamrock CorporationInventors: Larry J. Powers, Zaven S. Ariyan, Russell Buchman, James A. Scozzie, Robert E. Moser, William J. Pyne
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Patent number: 4238219Abstract: A composition consisting essentially of 2-chloroethylphosphonic acid and certain imides, carbamates, or tetrachloroisophthalonitrile, increases the ability of 2-chloroethylphosphonic acid alone to cause the release of ethylene in plant tissue when applied to same.Type: GrantFiled: February 21, 1978Date of Patent: December 9, 1980Assignee: Diamond Shamrock CorporationInventors: Robert E. Holm, Han San Ku
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Patent number: 4224334Abstract: Certain imidazothiazoles and thiazolopyrimidines have been found to prevent and inhibit the formation of granuloma tissue in animals. This result is accomplished by administering to the animal subject a therapeutically effective amount of a compound having the formula: ##STR1## wherein R is hydrogen or methyl, R' is hydrogen, lower alkyl or thioalkyl, carboxy methyl, or phenyl; R" is lower alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl. The hydrated precursors of certain of these compounds as well as the acid addition and quaternary salts of both the compounds and their hydrated precursors may be employed.Type: GrantFiled: April 2, 1979Date of Patent: September 23, 1980Assignee: Diamond Shamrock CorporationInventors: Robert E. Moser, Larry J. Powers, Zaven S. Ariyan
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Patent number: 4185630Abstract: Ostomy collection pouch appliances suitable for operation in a first, non-vented, or second, vented but substantially leak-proof, mode and provided with a sealed port member including a heat seal configuration which provides the user with directional information concerning proper opening of the port.Type: GrantFiled: August 15, 1977Date of Patent: January 29, 1980Assignee: Diamond Shamrock CorporationInventors: Erich Neumeier, Douglas J. Marver
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Patent number: 4160768Abstract: Certain imidazothiazoles and thiazolopyrimidines have been found to prevent and inhibit the formation of granuloma tissue in animals. This result is accomplished by administering to the animal subject a therapeutically effective amount of a compound having the formula: ##STR1## WHEREIN R is hydrogen or methyl, R' is hydrogen, lower alkyl or thioalkyl, carboxy methyl, or phenyl; R" is lower alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl. The hydrated precursors of certain of these compounds as well as the acid addition and quaternary salts of both the compounds and their hydrated precursors may be employed.Type: GrantFiled: March 2, 1978Date of Patent: July 10, 1979Assignee: Diamond Shamrock CorporationInventors: Robert E. Moser, Larry J. Powers, Zaven S. Ariyan
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Patent number: 4157392Abstract: Substituted 1,2,4-triazines, compositions thereof and methods of using same are described. The compounds of the invention exhibit a wide range of pharmacological activity including anti-inflammatory, analgesic, anti-pyretic, hypotensive and central nervous system effects.Type: GrantFiled: April 19, 1978Date of Patent: June 5, 1979Assignee: Diamond Shamrock CorporationInventors: James M. Gullo, William P. Heilman, Robert J. Wayner, Robert E. Moser
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Patent number: 4145209Abstract: A composition comprising two compounds from the group cycloheximide, 5-chloro-3-methyl-4-nitro-1H-pyrazole and glyoxal dioxime and optionally including an additive compound capable of enhancing the activity of the composition is a synergistic combination capable of promoting fruit, especially citrus fruit, abscission when applied to trees bearing same.Type: GrantFiled: February 7, 1977Date of Patent: March 20, 1979Assignee: Diamond Shamrock CorporationInventor: Robert E. Holm
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Patent number: 4110451Abstract: Certain imidazothiazoles and thiazolopyrimidines have been found to prevent and inhibit the formation of granuloma tissue in animals. This result is accomplished by administering to the animal subject a therapeutically effective amount of a compound having the formula: ##STR1## wherein R is hydrogen or methyl, R' is hydrogen, lower alkyl or thioalkyl, carboxy methyl, or phenyl; R" is lower alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl. The hydrated precursors of certain of these compounds as well as the acid addition and quaternary salts of both the compounds and their hydrated precursors may be employed.Type: GrantFiled: December 29, 1976Date of Patent: August 29, 1978Assignee: Diamond Shamrock CorporationInventors: Robert E. Moser, Larry J. Powers, Zaven S. Ariyan
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Patent number: 4105434Abstract: Herbicidally active 5,5'-bis-1,2,4-triazinyl compounds, compositions and methods of using same to control undesired vegetation.Type: GrantFiled: January 17, 1977Date of Patent: August 8, 1978Assignee: Diamond Shamrock CorporationInventors: William W. Paudler, Robert E. Moser, Norman M. Pollack
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Patent number: 4103016Abstract: Certain imidazothiazoles and thiazolopyrimidines have been found to prevent and inhibit the formation of granuloma tissue in animals. This result is accomplished by administering to the animal subject a therapeutically effective amount of a compound having the formula: ##STR1## wherein R is hydrogen or methyl, R' is hydrogen, lower alkyl or thioalkyl, carboxy methyl, or phenyl; R" is lower alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl. The hydrated precursors of certain of these compounds as well as the acid addition and quaternary salts of both the compounds and their hydrated precursors may be employed.Type: GrantFiled: December 22, 1976Date of Patent: July 25, 1978Assignee: Diamond Shamrock CorporationInventors: Robert E. Moser, Larry J. Powers, Zaven S. Ariyan
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Patent number: 4090863Abstract: A combination of 5-chloro-3-methyl-4-nitro-1H-pyrazole and certain imides, carbamates, or a phthalonitrile is a synergistic composition capable of promoting fruit, especially citrus fruit, abscission when applied to trees bearing same.Type: GrantFiled: August 11, 1975Date of Patent: May 23, 1978Assignee: Diamond Shamrock CorporationInventor: Robert E. Holm
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Patent number: 4073637Abstract: A combination of cycloheximide and certain imides or carbamates is a synergistic composition capable of promoting fruit, especially citrus fruit, abscission when applied to trees bearing same.Type: GrantFiled: August 11, 1975Date of Patent: February 14, 1978Assignee: Diamond Shamrock CorporationInventors: Robert E. Holm, Robert D. Battershell
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Patent number: 4041167Abstract: Certain imidazothiazoles and thiazolopyrimidines have been found to prevent and inhibit the formation of granuloma tissue in animals. This result is accomplished by administering to the animal subject a therapeutically effective amount of a compound having the formula: ##STR1## wherein R is hydrogen or methyl, R' is hydrogen, lower alkyl or thioalkyl, carboxy methyl, or phenyl; R" is lower alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl. The hydrated precursors of certain of these compounds as well as the acid addition and quaternary salts of both the compounds and their hydrated precursors may be employed.Type: GrantFiled: January 19, 1976Date of Patent: August 9, 1977Assignee: Diamond Shamrock CorporationInventors: Robert E. Moser, Larry J. Powers, Zaven S. Ariyan