Patents Represented by Attorney, Agent or Law Firm Susan K. Faris
  • Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
    Patent number: 6218165
    Abstract: The present invention relates to a novel improved protein mutant which produces low allergenic response in humans compared to the parent of that mutant. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: April 17, 2001
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • Microbial production of indigo
    Patent number: 6190892
    Abstract: There is provided an improved process for the biosynthetic production of indigo, the improvement comprising removing unwanted by-products such as isatin or indirubin from the broth in which such indigo is produced. Isatin can be removed by enzymatic activity using an isatin-removing enzyme such as an isatin hydrolase, or by other techniques such as process parameters (elevated temperature, pH), or by contacting the broth containing the isatin with appropriate adsorption compounds/compositions such as carbon or appropriate resins. Since isatin is the precursor of indirubin, the indirubin levels are decreased as a result of isatin removal.
    Type: Grant
    Filed: November 20, 1995
    Date of Patent: February 20, 2001
    Assignee: Genencor International, Inc.
    Inventors: Walter Weyler, Timothy C. Dodge, John J. Lauff, Dan J. Wendt
  • Cellulase producing actinomycetes, cellulase produced therefrom and method of producing same
    Patent number: 6190899
    Abstract: A novel cellulase composition is provided which is producible by an Actinomycete. The cellulase has an approximate calculated molecular weight of 35 kD and has a pH optimum at 40° C. of 6 and at 60° C. of 6 or less. Also provided is a DNA encoding said cellulase, a method for producing the cellulase and applications thereof.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: February 20, 2001
    Assignee: Genencor International, Inc.
    Inventors: Brian E. Jones, Wilhelmus A. H. Van Der Kleij, Piet Van Solingen, Walter Weyler
  • Cellulase producing Actinomycetes cellulase produced therefrom and method of producing same
    Patent number: 6187577
    Abstract: A novel cellulase composition is provided which is producible by an Actinomycete. The cellulase has an approximate calculated molecular weight of 36 kD and has a pH optimum at 40° C. of 8 and at 60° C. of 7. Also provided is a DNA encoding said cellulase, a method for producing the cellulase and applications thereof.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: February 13, 2001
    Assignee: Genecor International, Inc.
    Inventors: Brian E. Jones, Wilhelmus A. H. Van Der Kleij, Piet Van Solingen, Walter Weyler
  • Mutant EGIII cellulase, DNA encoding such EGIII compositions and methods for obtaining same
    Patent number: 6187732
    Abstract: The present invention relates to variant EGIII cellulases which have improved stability and/or performance. The variant cellulases have replacements at sensitive residues to improve stability and/or performance.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: February 13, 2001
    Assignee: Genencor International, Inc.
    Inventors: Timothy Fowler, Colin Mitchinson