Abstract: Methods of making tablets of a variety of physical forms are described. The tablets can be made into a wide variety of formulations. The invention further provides methods of making crystalline and amorphous anhydrous trehalose for use in formulating tablets suitable for use in dispensing pharmaceutical agents.
Type:
Grant
Filed:
February 9, 1996
Date of Patent:
September 28, 1999
Assignee:
Quadrant Holdings Cambridge Ltd
Inventors:
Bruce J. Roser, Julian Blair, Camilo Colaco, Ross Henry Morris Hatley
Abstract: A human basic fibroblast growth factor (FGF) protein analog wherein the cysteine at positions 78 and 96 is replaced by serine, and said analog exhibits the biological activity of native, human basic FGF.The DNA sequences encoding analogs of human acidic and basic fibroblast growth factors (FGF) can be recombinantly expressed to obtain practical amounts of proteins useful in effecting both pathologies related to persistent angiogenesis and wound healing and related tissue repair.
Type:
Grant
Filed:
February 12, 1990
Date of Patent:
January 12, 1999
Inventors:
John C. Fiddes, Judith A. Abraham, Andrew A. Protter
Abstract: The present invention is directed to oligonucleotides comprising nucleotide sequences sufficiently complementary to conserved regions of human immunodeficiency virus genetic material such that when bound to said region, the oligonucleotides effectively prevent expression of the genetic material.
Abstract: The invention provides methods of making rapidly soluble tablets of decreased weight compared to similar solid tablets. The invention further provides novel, rapidly soluble tablets of decreased weight compared to similar solid tablets. The tablets offer increased rates of dissolution and disintegration.