Patents Represented by Attorney, Agent or Law Firm T. Helen Payne
  • Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
    Patent number: 5541161
    Abstract: This invention relates to peptide derivatives which are useful anticoagulant agents.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: July 30, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: John L. Krstenansky, Simon J. T. Mao
  • Carbocyclic adenosine analogs useful as immunosuppressants
    Patent number: 5514688
    Abstract: This invention relates to carbocyclic adenosine compounds of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent,Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group,Q is NH.sub.2, halogen or hydrogen, andZ is hydrogen, halogen, or NH.sub.2 ;or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: May 7, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: David R. Borcherding, Carl K. Edwards, III, Ronald E. Esser
  • Carbocyclic nucleoside analogs useful as immunosuppressants
    Patent number: 5470857
    Abstract: This invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering an effective amount of a compound of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentenyl ring is in the CIS configuration relative to the bicyclic substituent,Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group,Q is NH.sub.2, halogen or hydrogen, andZ is hydrogen, halogen, or NH.sub.2 ;or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: November 28, 1995
    Assignee: Marion Merrell Dow Inc.
    Inventors: David R. Borcherding, Carl K. Edwards, III, Ronald E. Esser, Douglas L. Cole
  • 5'-vinylhalo-aristeromycin/adenosine analogs and immunosuppressants
    Patent number: 5470837
    Abstract: The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-vinylhalo-aristeromycin/adenosine analogs.
    Type: Grant
    Filed: June 16, 1994
    Date of Patent: November 28, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jeffrey A. Wolos, Niall S. Doherty, Esa T. Jarvi, James R. McCarthy
  • Polyamine phenols as radioprotective agents
    Patent number: 5354782
    Abstract: The present invention relates to certain polyamine phenols which are useful as radioprotective agents.
    Type: Grant
    Filed: August 30, 1993
    Date of Patent: October 11, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael L. Edwards, Ronald D. Snyder
  • 5'-amine substituted adenosine analogs as immunosuppressants
    Patent number: 5308837
    Abstract: The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-amine substituted adenosine analogs.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: May 3, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Terry L. Bowlin
  • Radiolabeled anticoagulant peptides
    Patent number: 5279812
    Abstract: This invention relates to the usage of anticoagulant peptide derivatives that are iodinated.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: January 18, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John L. Krstenansky, Simon J. T. Mao
  • Preparation of sulfated polysaccharide fractions
    Patent number: 5272261
    Abstract: Various peptides having affinity for sulfated polysaccharides such as heparin, dextran sulfate and Pentosan polysulfate are bound to resins and used in affinity chromatography to prepare anti-HIV sulfated polysaccharides.
    Type: Grant
    Filed: January 14, 1992
    Date of Patent: December 21, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Alan D. Cardin, Richard L. Jackson
  • Carbocyclic adenosine analogs useful as immunosuppressants
    Patent number: 5244896
    Abstract: This invention relates to novel carbocyclic adenosine compounds of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent,Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group,Q is NH.sub.2, halogen or hydrogen, andZ is hydrogen, halogen, or NH.sub.2 ;or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: September 14, 1993
    Assignee: Marion Merrell Dow Inc.
    Inventors: David R. Borcherding, Carl K. Edwards, III, Ronald E. Esser, Douglas L. Cole