Patents Represented by Attorney, Agent or Law Firm T. X. Witkowski
-
Patent number: 6682747Abstract: The present invention relates to orally administered suspensions of pharmaceutical active substances of the NSAID type, particularly the antirheumatic agent Meloxicam, which are stabilized by the addition of small amounts of highly dispersed silicon dioxide using high shear forces and adding small amounts of hydrophilic polymers to form a three-dimensional siloid structure, and a process for the preparation thereof.Type: GrantFiled: November 7, 2000Date of Patent: January 27, 2004Assignee: Boehringer Ingelheim Pharma KGInventors: Dietrich Türck, Veit Schmelmer
-
Patent number: 6660772Abstract: A method of treating urinary incontinence in a patient in need thereof, the method comprising administering to the patient an effective amount of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol or a pharmacologically acceptable salt thereof, and pharmaceutical compositions.Type: GrantFiled: January 30, 2002Date of Patent: December 9, 2003Assignee: Boehringer Ingelheim Pharma KGInventors: Pascale Pouzet, Franz Esser, Hisato Kitagawa, Naoki Ishiguro, Ikunobu Muramatsu
-
Patent number: 6653305Abstract: A compound of formula (I) wherein: Ra is a benzyl or 1-phenylethyl group or a phenyl group substituted by the groups R1 and R2, wherein: R1 is a hydrogen, fluorine, chlorine, or bromine atom, or a methyl, trifluoromethyl, cyano, or ethynyl group, and R2 is a hydrogen or fluorine atom; Rb is an R3O—CO—CH2—N—CH2—CH2—OH group optionally substituted at the methylene groups by 1 or 2 methyl or ethyl groups, wherein R3 is a hydrogen atom or a C1-4-alkyl group, a 2-oxomorpholin-4-yl group optionally substituted by 1 or 2 methyl or ethyl groups, or a N-[(1,3-dioxolan-2-yl)methyl]methylamino group; Rc is a hydrogen atom, or a methoxy, ethoxy, 2-methoxyethoxy, 2-ethoxyethoxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, cyclopropylmethoxy, cyclobutylmethoxy, cyclopentylmethoxy, cyclohexylmethoxy, tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetrahydropyran-4-yloxy, tetrahydrofuranylmethoxy, or tetrahydropyranylmethoxy group; and n is 1, 2, or 3Type: GrantFiled: August 15, 2001Date of Patent: November 25, 2003Assignee: Boehringer Ingelheim Pharma KGInventors: Frank Himmelsbach, Elke Langkopf, Birgit Jung, Stefan Blech, Flavio Solca
-
Patent number: 6576669Abstract: Medicaments and pharmaceutical kits comprising an LTB4 antagonist of formula (I) a tautomer thereof or a pharmaceutically acceptable salt thereof, and methods of treating or preventing cystic fibrosis, diseases caused by increased expression of mucin genes in the bronchial or gastrointestinal epithelium, or hyperplasia of goblet cells induced by toxins of products of pathogenic bacteria in a patient in need of such treatment, the method comprising administering to the patient a therapeutically effective amount of an LTB4 antagonist of formula (I).Type: GrantFiled: January 16, 2002Date of Patent: June 10, 2003Assignee: Boehringer Ingelheim Pharma KGInventors: Ralf Anderskewitz, Christopher J. Montague Meade, Franz Birke, Hans Michael Jennewein, Birgit Jung
-
Patent number: 6403790Abstract: A process for preparing epinastine hydrochloride of formula (I) the process comprising: (a) suspending and dissolving an epinastine base of formula (II) in water by the addition of aqueous hydrochloric acid at a pH of ≧7; (b) extracting the aqueous solution obtained from step (a) with an organic, water-immiscible solvent; (c) removing the organic, water-immiscible solvent from the aqueous solution obtained from step (b); and (d) adjusting the pH of the aqueous solution of step (c) to ≦6 using hydrochloric acid to precipitate the product of formula (I), and then drying the product.Type: GrantFiled: November 20, 2000Date of Patent: June 11, 2002Assignee: Boehringer Ingelheim Pharma KGInventor: Rolf Dach
-
Patent number: 6369271Abstract: The invention relates to a process for large-scale industrial production of biphenyl-2-carboxylic acid derivatives (I) wherein R1 and R2 may have the meanings given in the specification and claims.Type: GrantFiled: February 22, 2000Date of Patent: April 9, 2002Assignee: Boehringer Ingelheim Pharma KGInventor: Heinrich Schneider
-
Patent number: 6353007Abstract: 1-(4-Aminophenyl) indoles optionally substituted on the 2-,4-,5-,6- and 7-positions of the indole ring and on the amino group on the 4-position of the phenyl ring, which indoles inhibit IL-2 production in T-lymphocytes.Type: GrantFiled: July 13, 2000Date of Patent: March 5, 2002Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventor: Rajiv Sharma
-
Patent number: 6346545Abstract: The present invention relates to urethanes and the thio and dithio analogues thereof of general formula wherein m, n, A, X, Y and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.Type: GrantFiled: March 24, 1999Date of Patent: February 12, 2002Assignee: Boehringer Ingelheim Pharma KGInventors: Roland Maier, Rudolf Hurnaus, Michael Mark, Bernhard Eisele, Peter Mueller, Gebhard Adelgoss, Gebhard Schilcher
-
Patent number: 6323207Abstract: Novel benzoylguanidine derivatives of general formula I useful for the treatment or reduction of tissue damage due to ischaemia.Type: GrantFiled: September 15, 1999Date of Patent: November 27, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Christian Eickmeier, Erich Buerger, Stefan Matthias Blech, Otto Roos
-
Patent number: 6314796Abstract: Apparatus and process for non-destructively testing a fluid-filled container for leaktightness, the process comprising: (a) subjecting the fluid-filled container to a vacuum or near vacuum environment; (b) utilizing electrical equipment to form an electrical discharge in the vacuum or near vacuum environment sufficient to stimulate spectral light emissions from volatile fluid-filled container contents present in the vacuum or near vacuum environment; (c) detecting the spectral light emissions from the volatile fluid-filled container contents produced in step (b); and (d) evaluating the spectral light emissions detected in step (c) to determine the amount of volatile fluid-filled container contents present in the vacuum or near vacuum environment by comparing: (i) the measured brightness level of the spectral light emissions obtained from step (c), to (ii) a base brightness level obtained by measuring the brightness level of the spectral emissions due to the presence of residual gas or air molecules in theType: GrantFiled: August 2, 1999Date of Patent: November 13, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Juergen Wittekind, Gerhard Poss, Andreas Kuehnel
-
Patent number: 6313097Abstract: Compounds of the formula (I) wherein A, R, R1, R2, X1, X2, X3, and Y are as defined herein, and the tautomers and the pharmaceutically acceptable salts thereof, including pharmaceutical compositions containing these compounds, and their use in the selective antagonization of calcitonin gene-related peptide (CGRP) and in the treatment or prophylaxis of migraine or cluster headaches, non-insulin-dependent diabetes mellitus, inflammation, allergic rhinitis, asthma, morphine tolerance, menopausal hot flashes, and diseases characterized by excessive vasodilatation and consequent reduction in blood-flow.Type: GrantFiled: March 10, 2000Date of Patent: November 6, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Wolfgang Eberlein, Klaus Rudolf, Wolfhard Engel, Henri Doods, Gerhard Hallermayer
-
Patent number: 6300342Abstract: Antithrombotic phenylalkyl derivatives of the formula Exemplary compounds are: (a) 1-[3-(4-amidino-phenyl)propionyl]-6-(4-fluoro-phenylsulphonamido)-1,2,3,4-tetrahydro-quinoline, (b) 1-[3-(4-amidino-phenyl)propionyl]-6-butylsulphonamido-1,2,3,4-tetrahydro-quinoline, (c) 1-[3-(4-amidino-phenyl)propionyl]-5-phenylsulphonamido-1,2,3,4-tetrahydro-quinoline, (d) 1-[3-(4-amidino-phenyl)propionyl]-3-methyl-6-phenylsulphonamido-1,2,3,4-tetrahydro-quinoline, and, (e) 1-[3-(4-amidino-phenyl)propionyl]-6-(5-chloro-thien-2-ylsulphonamido)-1,2,3,4-tetrahydro-quinoline.Type: GrantFiled: December 9, 1999Date of Patent: October 9, 2001Assignee: Boehringer Ingelheim Pharm KGInventors: Armin Heckel, Rainer Soyka, Wolfgang Grell, Eric Haaksma, Klaus Binder, Rainer Zimmerman
-
Patent number: 6288277Abstract: The present invention relates to new phenylamine derivatives, processes for preparing them and their use as pharmaceutical compositions.Type: GrantFiled: April 3, 2000Date of Patent: September 11, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Franz Birke, Hans Michael Jennewein, Christopher John Montague Meade
-
Patent number: 6281218Abstract: Compounds of general formula (I) wherein R1, R2, R3, and R4 denote hydrogen or hydroxy with the proviso that R1, R2, R3, and R4 cannot simultaneously represent hydrogen, processes for their preparation of the compounds of general formula (I), and their use as pharmaceuticals.Type: GrantFiled: August 8, 2000Date of Patent: August 28, 2001Assignee: Ingelheim Italia S.p.A.Inventors: Enzo Cereda, Maura Bignotti, Giovanni Battista Schiavi
-
Patent number: 6268389Abstract: The present invention relates to the use of &agr;lL-agonists for treating urinary incontinence.Type: GrantFiled: January 11, 1999Date of Patent: July 31, 2001Assignee: Boehringer Ingelheim KGInventors: Franz Esser, Helmut Staehle, Sven Luettke, Ikunobu Muramatsu, Hisato Kitagawa, Shuji Uchida
-
Patent number: 6255329Abstract: The present invention relates to the use of 2-amino-4,5,6,7-tetrahydro-6-n-propylamino-benzothiazole (pramipexole), the (+)- or (−)- enantiomer thereof, or one of the pharmacologically acceptable salts thereof, in conjunction with sertraline for the improved treatment of depression and depressive states.Type: GrantFiled: July 6, 1999Date of Patent: July 3, 2001Assignee: Boehringer Ingelheim Pharma KGInventor: Jerzy Maj
-
Patent number: 6248770Abstract: The present invention relates to new benzimidazoles of general formula wherein Ra to Rc, A, Ar and B are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof the prodrugs, the derivatives thereof which contain a group which is negatively charged under physiological conditions, instead of a carboxy group, and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I wherein Rc denotes a cyano group are valuable intermediates for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein Rc denotes one of the amidino groups mentioned in claim 1 which have valuable pharmacological properties, particularly an antithrombotic activity.Type: GrantFiled: June 24, 1999Date of Patent: June 19, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Uwe Ries, Iris Kauffmann, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
-
Patent number: 6242466Abstract: Phenylamidines of the formula (I) wherein: R6 is a C5-12-alkyloxycarbonyl group, and R7 is a hydrogen atom, or a C1-8-alkyl, C4-7-cycloalkyl, phenyl-C1-4-alkyl, or R8—CO—OCHR9— group, wherein R8 is a C1-4-alkyl, C1-4-alkoxy, C3-7-cycloalkyl, or C4-7-cycloalkoxy group, and R9 is a hydrogen atom or a C1-4-alkyl group, or a tautomer or pharmaceutically acceptable salt thereof. These compounds inhibit cell aggregation and are useful for the treatment or prevention of thrombosis, inflammation, bone degradation, tumors and tumor metastasis.Type: GrantFiled: July 14, 1999Date of Patent: June 5, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Frank Himmelsbach, Brian Guth, Hans-Dieter Schubert
-
Patent number: 6235738Abstract: The invention relates to novel diphenyl-substituted heterocycles with 6-membered ring of general formula (I) in which A, X and the residues R1, R2, R3, R4 and R5 are as defined in the claims, processes for the preparation thereof and the use thereof as medicaments.Type: GrantFiled: April 12, 1999Date of Patent: May 22, 2001Assignees: Boehringer Ingelheim Pharma KG, Boehringer Ingelheim Italia S.p.A.Inventors: Michael Brenner, Rainer Palluk, Marion Wienrich, Thomas Weiser, Enzo Cereda, Maura Bignotti, Carlo Maria Pellegrini, Giovanni Battista Schiavi, Raffaele Cesana
-
Patent number: 6218575Abstract: An improved process for preparing adrenaline, or an addition salt thereof, on an industrial scale, with asymmetric hydrogenation as a key step and a special sequence of successive steps, using [Rh(COD)Cl]2 as catalyst and a chiral, bidentate phosphine ligand such as (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphinomethyl)-N-methylaminocarbonylpyrrolidine as the catalyst system.Type: GrantFiled: July 26, 2000Date of Patent: April 17, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Franz Dietrich Klingler, Lienhard Wolter