Abstract: A plural line CMOS sensor array device is provided with sensor cells arranged in a matrix of coordinate-wise rows and columns. Each cell comprises a photosensitive area, an output node, and a transfer gate for selectively interconnecting the photosensitive area and the output node. Along at least a first coordinate direction adjacent cells are functionally configured as mutually mirror-symmetric structures in that their proximate output nodes are facing each other and are arranged for separately feeding a respective output channel. Preferably, also in a second coordinate direction adjacent cells are functionally configured as mutually mirror-symmetric structures in that their proximate output nodes are facing each other and all such facing output nodes are separately feeding a respective column-directed output channel.

Abstract: The present invention provides a polymer delivery system for the in vivo binding and release of growth factors, preferably orthobiologic GF, comprising a hyperbranched polymer having physiologically-acceptable anionic phosphorous groups. The hyperbranched polymer is preferred to be a polyurea with phosphonate anions. This polymer can be cross-linked to form a network and provide a coating for implanted devices.

Abstract: The present invention relates to the use of zinc complexes of natural amino acids, especially L-arginine, L-lysine, L-ornithine, and other natural amino acids, in a molar ratio of about 1:2 (metal:amino acid), and formulations thereof. These pharmaceutical compositions offer better tolerated and faster acting regimens than common zinc salts (i.e., acetate, sulfate, etc.) for long term maintenance therapy of diseases caused by abnormal elevated copper levels, such as in Wilson's disease, inflammatory and fibrotic diseases and Alzheimer's disease.

Abstract: The present invention relates to hyperbranched copolymer networks containing hyperbranched copolymers that have perfluorocarbon and organosilicon entities that have high hydrophobicity, or high oleophobicity, or high thermal stability, or good adhesion to substrates, or any combinations thereof. This invention provides a further desirable combination of properties that include solubility before crosslinking, chemical resistance, and easy processibility. The copolymers may be crosslinked with a variety of crosslinking agents to give either rigid or elastomeric networks.

Abstract: An interactive multimedia applications device and method for an interactive multimedia application comprises one or more live media capture devices providing a media stream, an engine comprising a real time media processing module for processing said media stream, and rendering means connected to multimedia output devices. In addition, said device comprises (i) a virtual scenario description repository adapted for storing a plurality of scenarios expressed in a scenario programming language; (ii) a memory module adapted for storing an internal representation of one of said scenarios, and an internal representation of a virtual scene and (iii) a parser/loader for parsing a selected one of said plurality of scenarios, and loading it in said memory module.

Abstract: A method of using a line-scan sensor device to scan an image includes determining and removing. The device includes sensor cells arranged in a matrix of rows and columns. The determining includes determining when a pixel signal value from a pixel in a first row and in a column deviates from a pixel signal value from a pixel in a second row and in said column. The removing includes removing the pixel signal value of the pixel in the first row and in said column when the pixel signal value from the pixel in the first row and in said column deviates from the pixel signal value from the pixel in the second row and in said column. The pixel in the first row and in said column images a portion of the image and the pixel in the second row and in said column images the same portion of the image.

Abstract: This invention concerns compounds of adamantanamines and neramexane, including their pharmaceutically-acceptable salts, diesterioisomers, and formulations for treating Alzheimer's related dementias, depression, AIDS related dementias, as antivirals, inflammatory diseases such as rheumatoid arthritis, and cerebral ischemia, hyperlipidemia, and diabetes.

Abstract: Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials.

Abstract: Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-functional core materials with various branch cell reagents. The branch cell reagents are dimensionally large, relative to the amino/polyamino-initiator core and when reacted, produce generation=1 dendrimers directly in one step. There is also a method by which the dendrimers can be stabilized and that method is the reaction of the dendrimers with surface reactive molecules to pacify the reactive groups on the dendrimers.

Abstract: This invention concerns compounds of adamantanamines and neramexane, including their pharmaceutically-acceptable salts, diesterioisomers, and formulations for treating Alzheimer's related dementias, depression, AIDS related dementias, as antivirals, inflammatory diseases such as rheumatoid arthritis, and cerebral ischemia, hyperlipidemia, and diabetes.

Abstract: The present invention relates to use of a milk apoprotein or a mixture thereof to prevent or treat microbial or viral infection of the human or animal body. It is believed that this is achieved by inhibiting adhesion of potential pathogens. More preferably, at least one milk apoprotein or a mixture thereof is administered, simultaneously or sequentially, with either or both of at least one free fatty acid or a mixture thereof or a monoglyceride thereof; and/or at least one organic acid or a salt or ester thereof or a mixture thereof. The active agent(s) may be delivered by means of a pharmaceutically acceptable delivery system which includes parenteral solutions, ointments, eye drops, nasal sprays, intravaginal devices, surgical dressings, medical foods or drinks, oral healthcare formulations and medicaments for mucosal applications.

Abstract: A method of capturing a color image includes steps of operating a first sensor of a camera to integrate a first charge over a first time interval, operating a second sensor of the camera to integrate a second charge over a second time interval and scanning the first and second sensors to readout the respective first and second charges during a third time interval. The first time interval overlaps the second time interval. The third time interval includes no overlapping time with the first time interval. The third time interval includes no overlapping time with the second time interval.

Abstract: This invention concerns adamantanamines (e.g. memantine, amantadine, and rimantadine) and neramexane salts of thiomolybdic and thiotungstic acids, including their preparation and pharmaceutical compositions, as dual acting drugs. These salts are used to treat or potentially arrest the neurodegenerative pathophysiology, clinical signs and symptoms of dementia of the Alzheimer's type, Parkinson's, Huntington's, AIDS-related dementia and Schizophrenia and its cognitive deficits. Additional uses of these derivatives include antiviral activity.

Abstract: A method for joining a plurality of reticles is used for producing a semiconductor layout pattern, so that the reticles will collectively map a circuit arrangement on a semiconductor substrate. A plurality of matching patterns is provided that are each geometrically linked to a respective particular reticle and through detecting pairwise correspondence among the matching patterns likewise correspondence among the associated reticles is ascertained. In particular, the method has bulk sub-reticles and peripheral sub-reticles, and a first matching pattern associates to a peripheral sub-reticle that abuts a bulk sub-reticle and a second matching pattern to the bulk sub-reticle at such distance therefrom that fitting of the peripheral sub-reticle between the second matching pattern and the bulk sub-reticle allows matching of the first and second matching patterns. The bulk sub-reticles are used to constitute an array of sub-reticles.

Abstract: The present invention discloses novel dual prodrug compounds of formula (1), methods for their preparation and intermediates in their syntheses, formula (1): wherein A is a single bond, —O—, or —CH2—; m and n vary independently and are an integer from 1 to 15; p and q vary from 0 to an integer from 1 to 4; B is a single bond or —CR3R4; D is formula (2): or formula (3): and X is halogen; R1 to R4 are various substituents selected to optimize the physiochemical and biological properties such as, lipophilicity, bioavailability, and pharmacokinetics of compounds of Formula 1; and R1 and R2 or R3 and R4 may optionally be tethered together to form a 3- to 7-membered alicyclic ring. These compounds are useful for the treatment of various infections, metabolic, cardiovascular and neurological disorders.

Abstract: A CMOS imaging facility is implemented on a substrate through a set of pixel circuits that are array-wise organized in lines and columns and each comprise a radiation-to-charge accumulator (20), a transfer transistor (22) for transferring a representation of the charge, a reset transistor (24) fed by a reference voltage and a source follower transistor (26) for feeding a select transistor (28) that feeds the representation to an output array conductor. In particular, for respective pairs of adjacent column conductors the associated pixel transfer transistors will controllably pair wise share the accumulators in an interlace organization.

Abstract: Compounds of Formula 1 are dual prodrug compounds of the formula The various terms in Formula 1 are selected to optimize the physiochemical and biological properties such as, lipophilicity, bioavailability, and pharmacokinetics of compounds of Formula 1. These compounds are useful for the treatment of diabetes.

Abstract: The present invention relates to use of a milk apoprotein or a mixture thereof to prevent or treat microbial or viral infection of the human or animal body. It is believed that this is achieved by inhibiting adhesion of potential pathogens. More preferably, at least one milk apoprotein or a mixture thereof is administered, simultaneously or sequentially, with either or both of at least one free fatty acid or a mixture thereof or a monoglyceride thereof; and/or at least one organic acid or a salt or ester thereof or a mixture thereof. The active agent(s) may be delivered by means of a pharmaceutically acceptable delivery system which includes parenteral solutions, ointments, eye drops, nasal sprays, intravaginal devices, surgical dressings, medical foods or drinks, oral healthcare formulations and medicaments for mucosal applications.

Abstract: The invention relates to a semiconductor device with a semiconductor body comprising a CMOS image sensor with an active region having viewed in projection first sides and second sides perpendicular to the first sides said active region comprising a matrix of active pixels arranged in rows and columns, each pixel having a photosensitive region, the device further comprising a plurality of circuit elements for operating the pixel in the image forming process, the plurality of circuit elements comprising a first set of circuit elements for read-out of the columns and a second set of circuit elements for controlling the rows. According to the invention a first part of the plurality of circuit elements is positioned outside the matrix along one of the first sides and a second part of the plurality of circuit elements is positioned within the matrix of active pixels remote from the second sides.

Abstract: An array-based C-MOS sensor device is provided with a facility for on the basis of non-destructive cell readout generating a radiation dose-sensing signal. In particular, the facility is arranged for accessing a subset of multiple distributed C-MOS cells across the array and feeding by such accessed cells an algorithmic means for therein generating an overall feedback dose control signalization and/or an over-all trigger signalization.