Patents Represented by Attorney, Agent or Law Firm Thomas D. Webster
  • Streptococcus pneumoniae gene sequence mraY
    Patent number: 6271000
    Abstract: The invention provides isolated nucleic acid compounds encoding enzyme mraY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded enzyme, and a method for identifying compounds that inhibit said enzyme.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: August 7, 2001
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Robert Brown Peery, Paul Luther Skatrud, Michele Louise Young Bellido
  • Streptococcus pneumoniae gene sequence GCP
    Patent number: 6268175
    Abstract: The invention provides isolated nucleic acid compounds encoding gcp of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: July 31, 2001
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Joseph Chiou-Chung Tang, Patti Jean Treadway
  • Glucosyltransferase gene gtfe from Amycolatopsis orientalis
    Patent number: 6232102
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: May 15, 2001
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • Multiple drug resistance gene atrD of Aspergillus nidulans
    Patent number: 6228615
    Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrD are also provided. The invention further provides assays which utilize these transformed host cells.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: May 8, 2001
    Assignee: Eli Lilly and Company
    Inventors: Paul Luther Skatrud, Maarten A. de Waard, Alan C. Andrade, Robert Brown Peery
  • Isolate nucleic acid encoding human MGLUR8
    Patent number: 6221609
    Abstract: This invention describes a novel human glutamate receptor, designated mGluR8. This invention also encompasses nucleic acids encoding this receptor, or a fragment thereof, as well as methods employing this receptor and the nucleic acid compounds.
    Type: Grant
    Filed: May 13, 1997
    Date of Patent: April 24, 2001
    Assignee: Eli Lilly and Company
    Inventors: Rama M. Belagaje, Su Wu
  • Muri protein from Streptococcus pneumoniae
    Patent number: 6171834
    Abstract: The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: January 9, 2001
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Franklin Harpold Norris, Pamela Kay Rockey, Paul Robert Rosteck, Jr., Paul Luther Skatrud, Patti Jean Treadway, Michele Louise Young Bellido, Chyun-Yeh Earnest Wu
  • Streptococcus pneumoniae gene sequence dnaG
    Patent number: 6162617
    Abstract: The invention provides isolated nucleic acid compounds encoding dnaG of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: December 19, 2000
    Assignee: Eli Lilly and Company
    Inventors: Stanley Gene Burgett, Jo Ann Hoskins, Stanley Richard Jaskunas, Jr., Robert Brown Peery, Paul Robert Rosteck, Jr., Genshi Zhao
  • Monofunctional glycosyltransferase of Staphylococcus aureus
    Patent number: 6143868
    Abstract: The invention provides isolated nucleic acid compounds encoding a novel MTG of Staphylococcus aureus. Also provided are vectors and transformed heterologous host cells for expressing the MTG and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the MTG.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: November 7, 2000
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Stanley R. Jaskunas, Jr., Robert B. Peery, Paul L. Skatrud
  • Strepococcus pneumoniae gene sequence FtsH
    Patent number: 6136557
    Abstract: The invention provides isolated nucleic acid compounds encoding FtsH of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: October 24, 2000
    Assignee: Eli Lilly and Company
    Inventors: Robert Brown Peery, Paul Luther Skatrud, Q May Wang, Michele Louise Young Bellido
  • Glycosyltransferase gene gtfA from Amycolatopsis orientalis
    Patent number: 6087143
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfA of Amycolatopsis orientalis. Also provided are vectors carrying the gtfA gene, transformed heterologous host cells for expressing the GtfA protein, and methods for producing glycopeptide compounds using the cloned gtfA gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: July 11, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Streptococcus pneumoniae gene sequence HI1146
    Patent number: 6074847
    Abstract: The invention provides isolated nucleic acid compounds encoding HI1146 of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: June 13, 2000
    Assignee: Eli Lilly and Company
    Inventors: Robert Brown Peery, Paul Luther Skatrud, Patti Jean Treadway, Michele Louise Young Bellido
  • Streptococcus pneumoniaegene sequence era
    Patent number: 6071724
    Abstract: The invention provides isolated nucleic acid compounds encoding Era of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: June 6, 2000
    Assignee: Eli Lilly and Company
    Inventors: Robert Brown Peery, Michele Louise Young Bellido, Genshi Zhao
  • Multiple drug resistance gene atrc of Aspergillus nidulans
    Patent number: 6060264
    Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrC are also provided. The invention further provides assays which utilize these transformed host cells.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: May 9, 2000
    Assignee: Eli Lilly and Company
    Inventors: Paul Luther Skatrud, Maarten A. de Waard, Alan C. Andrade, Robert Brown Peery
  • Streptococcus pneumoniae gene sequence Dpj
    Patent number: 6060282
    Abstract: The invention provides isolated nucleic acid compounds encoding dpj of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: May 9, 2000
    Assignee: Eli Lilly and Company
    Inventors: Joseph Chiou-Chung Tang, Patti Jean Treadway, Genshi Zhao
  • Glycosyltransferase gene gtfC from Amycolatopsis orientalis
    Patent number: 6027928
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfC of Amycolatopsis orientalis. Also provided are vectors carrying the gtfC gene, transformed heterologous host cells for expressing the GtfC protein, and methods for producing glycopeptide compounds using the cloned gtfC gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: February 22, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glycosyltransferase gene gtfB from Amycolatopsis orientalis
    Patent number: 6025173
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfB of Amycolatopsis orientalis. Also provided are vectors carrying the gtfB gene, transformed heterologous host cells for expressing the GtfB protein, and methods for producing glycopeptide compounds using the cloned gtfB gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: February 15, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glycosyltransferase gene GFTD from amycolatopsis orientalis
    Patent number: 6025174
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfD of Amycolatopsis orientalis. Also provided are vectors carrying the gtfD gene, transformed heterologous host cells for expressing the GtfD protein, and methods for producing glycopeptide compounds using the cloned gtfD gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: February 15, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Fungal IPC synthase assay
    Patent number: 6022684
    Abstract: The presently-disclosed IPC synthase-inhibitor assays comprise the steps of: (1) expression of the IPC1 gene in a cell; (2) introducing labeled starting substrates for ceramide conversion as well as potential inhibitor(s) of such conversion to the expressed gene product in an environment which allows time and conditions for conversion, and (3) identifying those potential inhibitors which actually inhibit conversion.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: February 8, 2000
    Assignees: University of Kentucky Research Foundation, Eli Lilly and Company
    Inventors: Jeffrey Radding, Robert C. Dickson, Robert L. Lester
  • Diagnosis of colon carcinoma using monoclonal antibodies to human influx peptide transporter
    Patent number: 6001359
    Abstract: Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide transporter and in immunoassays to identify agents taken up into the cell by the human influx peptide transporter mechanism. The monoclonal antibodies are also useful for the detection and treatment of carcinomas derived from the gastrointestinal tract and pancreatic duct.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: December 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Stuart W. Bright, Anne H. Dantzig, Linda B. Tabas, J. Richard Sportsman
  • Method for knockout mutagenesis in Streptococcus pneumoniae
    Patent number: 5981281
    Abstract: Provided herein is a method to produce knockout mutations at targeted sites in the genome of Streptococcus pneumoniae.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: November 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard Henry Baltz, Jo Ann Hoskins, Patricia Jean Solenberg, Patti Jean Treadway