Abstract: This application for calibrating surface temperature measuring devices is used in chemical processes. The apparatus is portable and comprises a cylindrical metal rod with controlled heating means of accurately known surface temperature.

Abstract: The application discloses a combination medicament container and transfer device connected with a bellows type sleeve. The transfer device is a double ended spike having internal conduits optionally vented through a sterile hydropholic allowing two way transfer of liquid from an intravenous solution container and a medicament container of relatively insoluble medicament.

Abstract: Disclosed is a process for preparing antibiotic 1-oxadethiacephalosporins via diazo-species I: ##STR1## wherein: A is acyl; R.sup.1 is H or OCH.sub.3 ; and R.sup.2 is a protecting group.

Abstract: The invention relates to the treatment and prevention of injury to the gray matter of the brain and to the spinal chord due to accidents, ischemic stroke, cardiac arrest, arrested breathing, Reye's syndrome and hydrocephalus by the administration of (indanyloxy)butanoic acids, their derivatives, analogs and salts thereof.

Abstract: Novel substituted pyrazinyl-1,2,4-oxadiazoles and processes for preparing the same. The compounds are useful in the treatment of edema and hypertension.

Abstract: This invention relates to novel derivatives of imino diacetic acid of the formula: ##STR1## wherein R.sup.1 is selected from the group consisting of: ##STR2## wherein X is halo (chloro, bromo or iodo) and R.sup.2 is lower alkyl of from 1-5 carbon atoms. It also relates to a novel diagnostic kit for hepatobiliary imaging comprising ingredients employed in the intravenous injection of a complex of technetium 99m, and an imino diacetic acid of the above formula. It also relates to a process for preparing said compounds by reaction of nitrilotriacetic acid anhydride and an amine of the formula R.sup.1 NH.sub.2 wherein R.sup.1 is as defined hereinabove.

Abstract: Novel 4-substituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate kidney stone formation. A novel process for their preparation is also disclosed.

Abstract: A delivery device and method making use of a plunger which can be controllable reciprocated within a housing to regulate the amount of material expelled from the housing. The plunger includes an adjustable stop collar which can be adjustably positioned, preferably by depressing the sides of the collar. In addition, a piston within the housing is sealably releasable from the plunger.

Abstract: Aminocrotonyl derivatives of 3,5-dinitropyridines are disclosed to have activity in increasing the sensitivity of tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

Abstract: Aminocrotonyl derivatives of 4-nitropyridine N-oxides are disclosed to have activity in increasing the sensitivity of tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

Abstract: 8-Halo-6-nitro-1,2,4-triazolo[4,3-a]pyrazine and its corresponding 3-alkyl derivatives are prepared by converting amino-5,6-dichloropyrazinecarboxylic acid to 5-chloro-6-hydrazino-3-nitropyrazinamine and treating said hydrazino compound with a lower alkyl ortho ester of a loweraliphatic carboxylic acid to produce an 8-chloro-6-nitro-1,2,4-triazolo[4,3-a]pyrazine-5-amine or the corresponding 3-loweralkyl derivatives thereof.

Abstract: The present invention relates to aminoalkenoate ester derivatives of 2-amino-5-chloro-3-nitropyrazine useful as sensitizers of hypoxic tumor cells to therapeutic radiation. It also relates to the process of preparing such compounds by reaction of 2-amino-5,6-dichloro-3-nitro-pyrazine with an amino or alkylamino substituted .alpha.,.beta.-unsaturated alkenoate ester. In addition the application relates to pharmaceutical compositions containing such compounds and to methods of treatment comprising administering such compounds to patients undergoing radiation treatment to enhance the effectiveness of such treatment by sensitizing hypoxic tumor cells to therapeutic radiation.

Abstract: This disclosure relates to an improved, new convertible child-resistant 2-piece closure comprising an inner cap comprising a circular top panel and integrally attached depending skirt having internal threads for engagement with corresponding external threads surrounding a conventionally threaded container exit neck. A plurality of spaced apart depressions extend downwardly from the top panel of said inner cap. Projecting upwardly and arranged in the same concentric circle of the top panel of said inner cap are a plurality of ratchet lugs, shaped in ramp form. An outer cap is also formed of a circular top panel and integrally attached depending skirt. Integrally formed on the inner side of the outer cap top panel are a plurality of downwardly extending drive lugs positioned in a circle of equal radius as the depression and ratchet lugs on the inner cap top panel.

Abstract: Novel 4-substituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.

Abstract: 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives of the formula: ##STR1## where X and Y are independently selected from the group consisting of hydrogen, halogen, and C.sub.1-6 alkyl; provided that positions 2 and 6 of the substituted phenyl moiety may not be substituted by C.sub.3-6 alkyl; or a pharmaceutically acceptable salt thereof;useful in treating urinary tract, especially renal calcium oxalate lithiasis.

Abstract: Novel 6-bromo derivatives of cholesterol have the formula ##STR1## Such compounds are prepared from the known 6-iodocholesterol by treatment with cuprous bromide.These compounds, labelled with radioisotopes of Br-82 or Br-77, are localized in the adrenal, mammary and ovary tissue of female mammals and in the adrenal or prostate tissue of males when administered to such individuals. This provides a method for imaging adrenal, ovary or prostate tissue which is superior to use of the prior art 6-iodo-cholesterol.

Abstract: 2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: ##STR1## where R is hydrogen or C.sub.1-4 alkyl; andL is a lipophilic group consisting essentially of ##STR2## where R' is (a) hydrogen; (b) C.sub.1-3 alkyl; (c) benzyl; (d) pyridyl C.sub.1-3 alkyl or (e) (3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl) methyl; provided that positions 2 and 6 of the substituted phenyl moiety may not be substituted; or ##STR3## where R' has the same meaning as above; or a pharmaceutically acceptable salt thereof; useful in treating urinary tract, especially renal calcium oxalate lithiasis.

Abstract: 2-Substituted amino derivatives of 6-amino-3-chloro-5-nitropyrazin-2-yl are prepared by converting 3-amino-5,6-dichloropyrazinecarboxylic acid to 5,6-dichloro-3-nitropyrazinamine and treating said compound with an amine to produce the corresponding 2-substituted amino compound.

Abstract: Di(alkylamino) derivatives of chloronitropyrazines are prepared from dichloronitropyrazinamine by diazotization of the amine followed by halogen exchange to produce an intermediate dichloro-halo nitropyrazine followed by reaction with one or two moles of an alkyl amine to effect replacement of one or two of the pyrazine halogens.

Abstract: A molecular model of a relatively large molecule or a portion thereof is made up of a series of solid parallel and equidistant cross sections of rigid transparent plastic sheets representing space occupied by the atoms in the crystalline state. The adjacent cross sections are generated from x-ray crystal spectroscopic data providing crystal coordinates of the large molecules in computer readable form. Computer tapes of such data are used to print out numbered cross sections of the molecule showing coordinate plots of atoms intersecting such cross sections along a preselected coordinate axis. These cross sections are duplicated manually in clear rigid plastic sheets and assembled in order using appropriate spacer blocks to maintain accurate spacing of the adjacent cross section.