Patents Represented by Attorney, Agent or Law Firm Thomas E. Jackson
  • Antithrombotic agents
    Patent number: 6288105
    Abstract: This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: September 11, 2001
    Assignee: Eli Lilly and Company
    Inventors: Nickolay Y Chirgadze, Matthew J Fisher, Richard W Harper, Ho-Shen Lin, Jefferson R McCowan, Alan D Palkowitz, Daniel J Sall, Gerald F Smith, Kumiko Takeuchi, Minsheng Zhang
  • Antithrombotic Agents
    Patent number: 6271227
    Abstract: This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: August 7, 2001
    Assignee: Eli Lilly and Company
    Inventors: Nickolay Y Chirgadze, Matthew J Fisher, Richard W Harper, Ho-Shen Lin, Jefferson R McCowan, Alan D Palkowitz, Michael E Richett, Daniel J Sall, Gerald F Smith, Kumiko Takeuchi, Minsheng Zhang
  • Antithrombotic diamines
    Patent number: 6251921
    Abstract: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: June 26, 2001
    Assignee: Eli Lilly and Company
    Inventors: Jolie Anne Bastian, Nickolay Yuri Chirgadze, Michael Lyle Denney, Matthew Joseph Fisher, Robert James Foglesong, Richard Waltz Harper, Mary George Johnson, Valentine Joseph Klimkowski, Todd Jonathan Kohn, Ho-Shen Lin, Michael Patrick Lynch, Jefferson Ray McCowan, Alan David Palkowitz, Michael Enrico Richett, Daniel Jon Sall, Gerald Floyd Smith, Kumiko Takeuchi, Jennifer Marie Tinsley, Minsheng Zhang
  • Antithrombotic compound
    Patent number: 6214841
    Abstract: This application relates to a novel compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, processes and Intermediates for its preparation, pharmaceutical formulations comprising the novel compound of formula (I), and the use of the compound of formula (I) as an antithrombotic agent.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: April 10, 2001
    Assignee: Eli Lilly and Company
    Inventors: Charles Van Jackson, Kenneth Dean Kurz, Robert Theodore Shuman
  • Anticoagulant agents
    Patent number: 6200967
    Abstract: This invention relates to a compound of the Formula I X—C(O)—Y—G—R  I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: March 13, 2001
    Assignee: Eli Lilly and Company
    Inventors: Valentine J Klimkowski, Aaron L Schacht, Michael R Wiley
  • Anticoagulant agents
    Patent number: 6160176
    Abstract: This invention relates to a compound of the Formula IX-C(O)--Y-G-R I(wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: December 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: Valentine Joseph Klimkowski, Aaron Leigh Schacht, Michael Robert Wiley
  • Antithrombotic agents
    Patent number: 6124277
    Abstract: This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: September 26, 2000
    Assignee: Eli Lilly and Company
    Inventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
  • Carbamoly substituted heterocycles
    Patent number: 6114534
    Abstract: This invention relates to carbamoyl substituted heterocycles which are .omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: September 5, 2000
    Assignee: Eli Lilly and Company
    Inventors: Joseph Anothony Jakubowski, Dale Eugene Mais, Kumiko Takeuchi
  • Antithrombotic agents
    Patent number: 6090787
    Abstract: This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
  • Carbamoyl substituted heterocycles
    Patent number: 6075147
    Abstract: This invention relates to carbamoyl substituted heterocycles which are .omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: June 13, 2000
    Assignee: Eli Lilly and Company
    Inventors: Joseph Anothony Jakubowski, Dale Eugene Mais, Kumiko Takeuchi
  • Anticoagulant agents
    Patent number: 6034104
    Abstract: This invention relates to a compound of the Formula IX--C(O)--Y--G--R I(wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: March 7, 2000
    Assignee: Eli Lilly and Company
    Inventors: Valentine Joseph Klimkowski, Aaron Leigh Schacht, Michael Robert Wiley
  • Intermediates in the preparation of substituted alkenoic acids
    Patent number: 6031095
    Abstract: This invention relates to a highly selective process for preparation of E-.omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefor.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: February 29, 2000
    Assignee: Eli Lilly and Company
    Inventors: Katrina Ann Nelson, Joseph John Nunes
  • Antithrombotic diamines
    Patent number: 6025382
    Abstract: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: February 15, 2000
    Assignee: Eli Lilly and Company
    Inventors: Jolie Anne Bastian, Nickolay Yuri Chirgadze, Michael Lyle Denney, Matthew Joseph Fisher, Robert James Foglesong, Richard Waltz Harper, Mary George Johnson, Valentine Joseph Klimkowski, Todd Jonathan Kohn, Ho-Shen Lin, Michael Patrick Lynch, Jefferson Ray McCowan, Alan David Palkowitz, Michael Enrico Richett, Daniel Jon Sall, Gerald Floyd Smith, Kumiko Takeuchi, Jennifer Marie Tinsley, Minsheng Zhang
  • Intermediate for synthesis of anticoagulant agents
    Patent number: 6008367
    Abstract: This invention relates to a chemical intermediate ##STR1## wherein f is 0, 1, 2 or 3, which is useful for the synthesis of a compound of the Formula IX--C(O)--Y--G--R I(wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, which compound of Formula I or salt and pharmaceutical compositions comprising such a compound or salt are useful as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: December 28, 1999
    Assignee: Eli Lilly and Company
    Inventors: Valentine Joseph Klimkowski, Aaron Leigh Schacht, Michael Robert Wiley
  • Intermediates in the preparation of substituted alkenoic acids
    Patent number: 5990308
    Abstract: This invention relates to a highly selective process for preparation of E-.omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefore.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: November 23, 1999
    Assignee: Eli Lilly and Company
    Inventors: Katrina Ann Nelson, Joseph John Nunes
  • Antithrombotic agents
    Patent number: 5914319
    Abstract: This invention relates to thrombin inhibiting compounds having the Formula IX--Y--NH--(CH.sub.2).sub.r --G Iwhere X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.
    Type: Grant
    Filed: September 1, 1995
    Date of Patent: June 22, 1999
    Assignee: Eli Lilly and Company
    Inventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
  • Antithrombotic agents
    Patent number: 5885967
    Abstract: This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: March 23, 1999
    Assignee: Eli Lilly and Company
    Inventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
  • Anticoagulant agents
    Patent number: 5863929
    Abstract: This invention relates to a compound of the Formula IX--C(O)--Y--G--R I(wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: January 26, 1999
    Assignee: Eli Lilly and Company
    Inventors: Valentine Joseph Klimkowski, Aaron Leigh Schacht, Michael Robert Wiley
  • Preparation of substituted alkenoic acids
    Patent number: 5849922
    Abstract: This invention relates to a highly selective process for preparation of E-.omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefor.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: December 15, 1998
    Assignee: Eli Lilly and Company
    Inventors: Katrina Ann Nelson, Joseph John Nunes
  • Carbamoyl substituted heterocycles
    Patent number: 5849766
    Abstract: This invention relates to carbamoyl substituted heterocycles which are .omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: December 15, 1998
    Assignee: Eli Lilly and Company
    Inventors: Joseph Anothony Jakubowski, Dale Eugene Mais, Kumiko Takeuchi