Abstract: The invention provides compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen or alkyl(C.sub.1-10), andR.sub.2 is alkyl(C.sub.1-10),and physiologically acceptable and hydrolysable esters thereof, useful as anti-allergic agents.
Abstract: Novel Cephalosporin C derivatives, their production and their use in isolating Cephalosporin C from culture filtrates for subsequent conversion of 7-aminocephalosporanic acid.
Abstract: The invention provides novel penicillins and cephalosporins of formula I, ##STR1## methods for their production and their anti-bacterial use.
Type:
Grant
Filed:
February 6, 1980
Date of Patent:
March 16, 1982
Assignee:
Sandoz Ltd.
Inventors:
Helmut Hamberger, Peter Stutz, Dieter Scholz, Hans Fliri
Abstract: The analgesic use of compounds of formula I ##STR1## wherein R is hydrogen, acetyl or a group of formula IIR'--O--CO-- IIwherein R' is alkyl (C.sub.1-8); phenyl; phenyl substituted in the 4-position with halogen, alkoxy(C.sub.1-4) or alkyl(C.sub.1-4); phenylalkyl; or phenylalkyl in which the phenyl group is substituted in the 4-position with halogen, alkoxy(C.sub.1-4) or alkyl (C.sub.1-4).
Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent hydrogen, or ##STR2## and R.sub.3 is hydrogen or fluoro, andn is 1, 2 or 3, andprovided that one of R.sub.1 and R.sub.2 is other than hydrogen which are useful as anti-obesity agents.
Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, andR.sub.3 represents hydrogen or lower alkyl, andX represents ##STR2## which are useful as sleep inducers.
Abstract: The present invention provides anti-9,10-dihydro-4-(1-methyl-4-piperidylidene)-4H-benzo[4,5]-cyclohepta[1 ,2-b]thiophen-10(9H)-one oxime of formula ##STR1## useful for the treatment of allergic conditions.
Type:
Grant
Filed:
January 8, 1980
Date of Patent:
June 16, 1981
Assignee:
Sandoz Ltd.
Inventors:
Erwin Waldvogel, Jean-Michel Bastian, Gustav Schwarb
Abstract: Novel Cephalosporin C derivatives, their production and their use in isolating Cephalosporin C from culture filtrates for subsequent conversion to 7-aminocephalosporanic acid.
Abstract: The compounds of formula I ##STR1## wherein R is(a) hydrogen,(b) cycloalkyl of 3 to 7 carbon atoms,(c) alkyl of 2 to 5 carbon atoms monosubstituted by hydroxy, with the proviso that the hydroxyl radical is separated by at least 2 carbon atoms from the carbonylthio moiety to which R is bound,(d) phenyl or phenylalkyl of 7 to 11 carbon atoms, each monosubstituted or independently disubstituted in the phenyl ring by alkyl of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35, or phenyl or phenylalkyl of 7 to 11 carbon atoms, each monosubstituted or independently disubstituted or independently trisubstituted in the phenyl ring by alkoxy of 1 to 4 carbon atoms, or(e) furyl, benzo[b]furyl, thienyl, benzo[b]thienyl, pyridyl, quinolyl, isoquinolyl, 2- or 3-pyrrolyl or indolyl other than 1-indolyl,R.sub.1 and R.sub.
Abstract: This invention provides new compounds of the formula, ##STR1## wherein R.sub.1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 8 carbon atoms or phenyl,R.sub.2 is hydrogen or lower alkyl, andR.sub.3 is halogen, nitro, lower alkyl, methylthio, hydroxy, lower alkoxy, acyloxy or acylamino, with the proviso that when R.sub.3 is in the 5 position, and R.sub.1 and R.sub.3 are identical and signify a straight alkyl chain of 1 to 5 carbon atoms, R.sub.2 is lower alkyl,useful as anti-phlogistics.
Type:
Grant
Filed:
May 11, 1979
Date of Patent:
February 24, 1981
Assignee:
Sandoz Ltd.
Inventors:
Annemarie Closse, Walter Haefliger, Daniel Hauser
Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-iminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers and sleep inducers.
Abstract: This invention provides compounds of formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, alkenyl or alkynyl, the multiple bond of which is not adjacent to the nitrogen atom,R.sub.2 is, for example, hydrogen, alkyl, alkoxy, hydroxy or halogen, andR.sub.3 is hydrogen, halogen, hydroxyl, alkyl or alkoxy,useful, for example, in the treatment of allergic asthma.
Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, andX represents ##STR2## which are useful as minor tranquilizers and sleep inducers.
Abstract: This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each independently represent lower alkyl having 1 to 2 carbon atoms, andn is 1 or 2,which are useful as muscle-relaxant agents.
Abstract: This disclosure describes novel compounds of the formula: ##STR1## where A is --CH.sub.2 OH or ##STR2## wherein R.sub.4 and R.sub.5 each independently represent hydrogen or lower alkyl having 1 to 2 carbon atoms or together with N represent ##STR3## and, R.sub.1 is hydrogen or lower alkyl having 1 to 2 carbon atoms, andR.sub.2 and R.sub.3 each independently represent hydrogen, chloro, fluoro, methyl, methoxy or together, represent methylenedioxy, andn is 1 or 2, provided that one of R.sub.2 and R.sub.3 is other than hydrogen which are useful as hypolipidemic agents.