Patents Represented by Attorney Timothy J. Douros
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Patent number: 7408025Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.Type: GrantFiled: December 15, 2000Date of Patent: August 5, 2008Assignee: Cubist Pharmaceuticals, Inc.Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
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Patent number: 7335726Abstract: The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.Type: GrantFiled: June 6, 2006Date of Patent: February 26, 2008Assignee: Cubist Pharmaceuticals, Inc.Inventors: Michael Morytko, Yanzhi Zhang, Michael Jung, John Finn
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Patent number: 7335725Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.Type: GrantFiled: May 4, 2005Date of Patent: February 26, 2008Assignee: Cubist Pharmaceuticals, Inc.Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
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Patent number: 7262268Abstract: The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.Type: GrantFiled: August 6, 2002Date of Patent: August 28, 2007Assignee: Cubist Pharmaceuticals, Inc.Inventors: Michael Morytko, Yanzhi Zhang, Michael Jung, John Finn
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Patent number: 6911525Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.Type: GrantFiled: December 15, 2000Date of Patent: June 28, 2005Assignee: Cubist Pharmaceuticals, Inc.Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
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Patent number: 6852689Abstract: The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a dosing interval of 24 hours or greater. This long dosing interval minimizes skeletal muscle toxicity and allows for higher peak concentrations of daptomycin, which is related to daptomycin's efficacy. The invention also provides methods of administering lipopeptide antibiotics other than daptomycin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of the lipopeptide antibiotic at a dosage interval that does not result in muscle toxicity. The invention also provides methods of administering quinupristin/dalfopristin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of quinupristin/dalfopristin at a dosage interval that dos not result in muscle toxicity.Type: GrantFiled: February 20, 2002Date of Patent: February 8, 2005Assignee: Cubist Pharmaceuticals, Inc.Inventors: Frederick B. Oleson, Jr., Francis P. Tally
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Patent number: 6794490Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.Type: GrantFiled: December 15, 2000Date of Patent: September 21, 2004Assignee: Cubist Pharmaceuticals, Inc.Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
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Patent number: 6696412Abstract: The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of Streptomyces roseosporus. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.Type: GrantFiled: November 28, 2000Date of Patent: February 24, 2004Assignee: Cubist Pharmaceuticals, Inc.Inventors: Thomas J. Kelleher, Jan-Ji Lai, Joseph P. DeCourcey, Paul Lynch, Maurizio Zenoni, Auro Tagliani
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Patent number: 6384232Abstract: The invention provides improved and simplified methods of synthesizing ligands containing a heteroatom-bearing bridge using a novel intermediate compound. The ligands may be used to form metal complexes that are useful in diagnostic and therapeutic applications.Type: GrantFiled: March 27, 2001Date of Patent: May 7, 2002Assignee: Bracco International B.V.Inventor: Kondareddiar Ramalingam
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Patent number: 6309635Abstract: A method is provided whereby cells having a desired function are seeded on and into biocompatible, biodegradable or non-degradable porous polymer scaffolding matrix, previously implanted in a patient and infiltrated with blood vessels and connective tissue, to produce a functional organ equivalent. The resulting organoid is a chimera formed of parenchymal elements of the donated tissue and vascular and matrix elements of the host. The matrix should be compression resistant and a non-toxic, porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, should allow vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix, and the injection of cells such as hepatocytes without damage to the cells or patient. The introduced cells attach to the connective tissue and are fed by the blood vessels.Type: GrantFiled: November 28, 1994Date of Patent: October 30, 2001Assignees: Children's Medical Center Corp., Massachusetts Institute of TechnologyInventors: Donald E. Ingber, Robert S. Langer, Joseph P. Vacanti