Abstract: Method and circuitry for automatic resetting of an integrated circuit upon power up handles multiple clock sources and minimizes power dissipation. A robust voltage sensing circuit detects power up and triggers resetting of most of the circuit with the exception of the initialization circuit that includes an internal oscillator. After the circuit determines that the internal oscillator signal has settled, contents of non-volatile register are read to select the clock source for the circuit. Upon successful selection and clean up of system clock, the reset is removed.

Abstract: Intracellular free calcium concentrations are lowered by administering certain dihydropyridine derivatives to cells. Dihydropyridine and other test compounds are screened for their ability to lower intracellular free calcium, particularly by inhibiting the influx of calcium through calcium leak channels, and the identified compounds incorporated into pharmaceutical compositions. Exemplary dihydropyridine derivative compounds include 4-(3-trifluoromethylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyr idine; 4-(4-bromophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine; 4-(4-trifluoromethylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyr idine; 4-(4-methylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine; and 4-(4-cyanophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine.