Abstract: The present disclosure describes a tissue system with conjunctival cells, including conjunctival stem cells. The conjunctival tissue system is derived from isolated tissue comprising conjunctival cells, and is suitable for restoring ocular surface impairments, particularly those that result from damaged or diseased conjunctiva. The tissue system is generated using a simple single medium culture scheme, and a support material, such as human amniotic membrane. The conjunctival tissue system generate is suitable for transplantation to treat the ocular surface of an eye of a subject that is damaged or diseased.

Abstract: The present disclosure provides methods of using unsealed and non-colloidal radiopharmaceuticals, for example beta emitting radiopharmaceuticals such as Yttrium-90 chloride, Indium-111 chloride, F-18-2-deoxy-2-fluoro-D-glucose, or combinations thereof, for locoregional ablation of cells in the abnormal tissue.

Abstract: Compositions containing biologically active peptides are disclosed. Active peptides are isolated fragments derived from human hair or sheep wool keratin proteins. Compositions may be prepared for pharmaceutical or topical administration or for use in cosmetic preparations.

Abstract: The present disclosure is directed to processes for manufacturing internally pierced shaped articles for unit-dose packaging with at least one formed recess (e.g., a blister), in particular for unit-dose packaging of pharmaceutical dosage forms. In certain embodiments, the first step of the process is directed to drawing the film material (e.g., metal-plastic foil) with one or more plungers to form a primary contour, the contour having a depth of at least 100% and up to 150% of the depth of the formed recess. The second stage involves shaping the primary contour with one or more plunger(s) to the desired formed recess, with a depth that is less than the depth of the primary contour, while substantially maintaining the surface area of the primary contour formed in the first stage. The formed recess may be formed using warm-forming or cold-forming techniques. The third stage involves the automatic placing of an internal piercing device stably into the shaped article.

Abstract: The present disclosure describes the generation of neural cells and neurons from mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. Specifically, the present disclosure describes the generation of neuroprogenitor cells and differentiated dopaminergic neurons from ELSCs. The disclosed methods demonstrate the potential of ELSCs as a therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries. Neuroprogenitor cells generated from ELSCs isolated from corneo-limbal tissue were transplanted into a rat model of Parkinson's disease, and were able to alleviate motor abnormalities in the rats for at least six months.

Abstract: The present disclosure details a thermoacoustic driven compressor having a pressurized housing, which contains within a thermoacoustic engine and a working gas, coupled to a positive displacement reciprocating compressor. The thermoacoustic driven compressor generates scalable compressed air from a given heat source.

Abstract: The invention relates to a material for use as bone void filler comprising soluble keratin protein. The material may be in the form of a putty, gel or emulsion. Additional components may be added to the material to improve handling characteristics and bone enhancement capabilities. The material may be formulated to serve as a suitable carrier for demineralized bone matrix. This invention also describes methods for making the material.

Abstract: A pump iron restraint system is disclosed in which a fastening system is coupled to successive pump iron joints and a wireline is threaded through the fastening system. The fastening system may comprise a pair of endless flat straps, each of which is coupled to one of the pump iron joints. The eyes of the endless flat straps are placed around the interior arch of the screw pin shackle. A wireline is placed through the spaced formed by the screw pin and the screw pin shackle. The wireline is secured at the well site so that the wireline is taut.

Abstract: The invention relates to a porous keratin construct material comprising keratin protein for use in wound healing applications. The porous keratin construct is capable of bio-absorbing into a wound to promote wound healing. The rate at which the construct bio-absorbs into the wound may be controlled altered by controlling the degree of disulfide cross-linking between the keratin proteins in the porous keratin construct. The invention is also related to a method of making the porous keratin construct.

Abstract: Useful materials are produced from keratin containing raw materials by a process that includes gentle lanthionization of cystine disulfide bonds. Hydratable materials are produced for use in medical and cosmetic applications.

Abstract: The present disclosure describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. The ELSCs of the present disclosure are capable of proliferating in an in vitro culture, maintain the potential to differentiate into cells of endoderm, mesoderm, and ectoderm lineage in culture, and are capable of forming embryoid-like bodies when placed in suspension culture. Thus, these cells possess multi-lineage differentiation potential and self-renewing capability. ELSCs may be a promising therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries.

Abstract: Stable aqueous solutions comprising concentrations of baclofen in the range of greater than 2.0 mg/mL up to about 10 mg/mL are disclosed. These solutions can be used as pharmaceuticals for parenteral or oral administration. The invention also provides methods of preparing said stable aqueous baclofen solutions.

Abstract: A system and method of marketing commodity products over an internet connection, in which the product price is continuously correlated to a publicly traded exchange price and in which a customer may be notified if the product price reaches a previously selected target price set by the customer.

Abstract: Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.

Abstract: An applicator device for applying a substance to an area of the body that is difficult to reach includes a collapsible handle and a head portion rotatably mounted on one end. The head portion includes an attachment means, which can comprise either a field of hooks or a field of loops. The attachment means receives a two-sided pad engagement member that preferably has fields of loops or hooks on one side to engage the respective hooks or loops of the attachment member, and a field of hooks on its opposite side. The hooks of the pad engagement member can securely retain a pad that carries the substance to be applied to the body.

Abstract: Insulated jackets for beverage containers are disclosed having a seamless, fabric-covered, finished upper edge. The insulated jackets disclosed also comprise a partially of fully fabric-covered interior surface. Also disclosed are blanks for forming the disclosed insulated jackets for beverage containers.