Abstract: This invention provides an apparatus and process for automatically coating solid pharmaceutical dosage forms, e.g., tablets. The apparatus comprises a coating pan, having a rotating means, e.g., motor and a weighing means, e.g., scales in combination with the pan and motor. A process controller is in electronic communication with both the pan motor and scales, for controlling the pan rotation and monitoring the weight of the coating pan contents. There is also provided a plurality of material containing reservoirs having conduit means communicating with the interior of the pan. The material containing reservoirs may also have weighing means, e.g., scales in combination with the reservoirs, which are also in electronic communication with the process controller. These reservoirs may contain a water supply, a coating syrup supply, color suspension supply, and polishing ingredients for use in coating the tablets.

Abstract: A non-irritating injectable dosage form of a tissue irritating medicament, comprising the medicament and a pharmaceutically acceptable glyceride vehicle comprising a glycerol ester of a saturated or unsaturated fatty acid having from 6 to 20 carbon atoms or mixtures thereof.

Abstract: The present invention provides a pharmaceutical composition for controlled release of 4-(2-hydroxy-3-isopropylamino-propoxy) indole in the intestinal tract, admixed with sodium lauryl sulphate, and enteric coated.

Abstract: Hollow fiber apparatus for the fractionation of fluid, especially useful as an artificial kidney, is disclosed, characterized principally in that it comprises:a mandrel in the form of a truncated cone towards the ends of which two so-called end walls are situated, which surround the said mandrel and by which hollow fibers are held, the fibers extending from one end wall to the other, at least one of the end walls being sealed and traversed by the open ends of the hollow fibers,an outer casing of which the inner wall is in the form of a truncated cone at least along the greater part of its length near the hollow fibers.means for the intake and/or discharge of the fluid which circulates inside the hollow fibers, andmeans for the intake and/or discharge for the fluid which circulates over the outer wall of the fibers.Process and apparatus for manufacturing the hollow fiber apparatus are also disclosed.

Abstract: A double lumen, single needle, catheter is provided having an improved insertion tip which aleviates the trauma induced when inserted in a blood vessel or fistula.

Abstract: There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbing the biologically active material upon preformed submicroscopic polymer particles. Where the biologically active material is an antigen, the particles are useful as constituents of injectable vaccines having an adjuvant effect.

Abstract: Inflatable cuff-type catheters, e.g., endotracheal and tracheotomy tubes, with cuff pressure indicators are provided. One indicator means comprises an expandable chamber with an open-ended spring about the mid-section of the chamber. As the chamber expands, the spring also expands to indicate the gas pressure in the cuff.

Abstract: The invention concerns an improved hollow fibre apparatus for the fractionation of fluid, comprising;a mandrel, sealing elements located at the ends of the mandrel and by which the hollow fibres are held, the fibres extending from one sealing element to the other, at least one of these sealing elements being traversed by the hollow fibres so that open ends of the fibres are exposed at an outer side of such sealing element,a casing, which is arranged at least around the hollow fibres and the sealing elements and defining a chamber between the inner wall of the casing, the opposing inner sides of the sealing elements and the mandrel,first inlet and/or outlet means for introducing and/or discharging of fluid through the inside of the hollow fibres, andsecond inlet and outlet means for introducing and discharging of fluid into the chamber outside the fibres, said second inlet and outlet means opening into and from the chamber at the periphery of the mandrel and adjacent the inner sides of each sealing element.

Abstract: The invention concerns a haemodialyzer of the type comprising a semipermeable flattened tubular membrane wound in spiral configuration from one end with an interposed insert around a mandrel member, means for connecting the interior of said membrane at its ends to conduits for the admission and discharge of blood, the assembly being housed in a casing in which said mandrel member comprises at least two similar elongated elements which are connected together.

Abstract: There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbing the biologically active material upon preformed submicroscopic polymer particles. Where the biologically active material is an antigen, the particles are useful as constituents of injectable vaccines having an adjuvant effect.

Abstract: A process and apparatus are disclosed for the simultaneous preparation of several hollow fiber devices especially useful for fluid fractionation operations, wherein at least one hollow fiber is wound around means, at least three in number, located in different planes thereby obtaining with this fiber an envelope having a polygonal section, which can be cut in at least two places as it is formed, so as to obtain at least two distinct groups of hollow fiber lengths. Various specific embodiments are described.

Abstract: Hollow fiber apparatus for the fractionation of fluid, especially useful as an artificial kidney, is disclosed, characterized principally in that it comprises:a mandrel in the form of a truncated cone towards the ends of which two so-called end walls are situated, which surround the said mandrel and by which hollow fibers are held, the fibers extending from one end wall to the other, at least one of the end walls being sealed and traversed by the open ends of the hollow fibers,an outer casing of which the inner wall is in the form of a truncated cone at least along the greater part of its length near the hollow fibers,means for the intake and/or discharge of the fluid which circulates inside the hollow fibers, andmeans for the intake and/or discharge for the fluid which circulates over the outer wall of the fibers.Process and apparatus for manufacturing the hollow fiber apparatus are also disclosed.

Abstract: Inflatable cuff-type catheters, e.g., endotracheal and tracheotomy tubes, with cuff pressure indicators are provided. One indicator comprises an expandable chamber with an open-ended spring about the mid-section of the chamber. As the chamber expands, the spring also expands to indicate the gas pressure in the cuff.

Abstract: Aluminum hydrogels which are stabilized at pH below 7 with a polymer containingcarboxyl groups, e.g., carboxy methyl cellulose or gum arabic. The gels are useful as phosphate binding agents in the treatment of hyperphosphatemia. Such polymers are incorporated during the formation of the aluminum hydrogel, permitting a high yield to be obtained, and preventing colloidal sol formation during exchange with monovalent anions.

Abstract: The invention concerns hollow fibre apparatus for the fractionation of fluids which comprises,a mandrel towards the ends of which two sealing elements are situated which surround the said mandrel and by which the hollow fibres are held, the fibres extending from one sealing element to the other, at least one of these sealing elements being traversed by the hollow fibres so that open ends thereof are exposed at an outer side thereof and having an inner side opposite to the inner side of the other sealing element which is inclined at least in part with respect to the longitudinal axis of the mandrel, a casing which is arranged at least around the hollow fibres and the sealing elements and which defines, between its inner wall, the inner sides of the sealing elements and the mandrel, a chamber in which the hollow fibres are arranged,first inlet and/or outlet means for introducing and/or withdrawing fluid which is circulated inside the hollow fibres, and second inlet and outlet means for introducing and withdrawi

Abstract: Microspheres, prepared by the low-temperature e.g., -40.degree. to -100.degree. C., phase separation of a polymer and a core material.

Abstract: The invention concerns a novel device for measuring the conductivity of a solution, comprising a probe having at least two electrodes for immersion in the solution, and converter means for converting the output from the electrodes which is proportional to the conductivity of the solution into an output having a frequency which is proportional to said conductivity. The converter means may comprise a difference amplifier operating as an oscillator.

Abstract: Normal breathing cycles of a ventilator cause an alarm controller circuit to emit a periodic pulse which resets a timer circuit thereby maintaining an alarm device in an "off" condition. Patient disconnect is sensed by an alarm trigger circuit which sends an inhibit pulse to the controller circuit inhibiting the timer circuit reset pulse. This causes the timer to "time out" thereby turning on an alarm actuator circuit which causes an audible and/or visual alarm condition.