Abstract: Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto. The compounds prepared by the present processes may be useful, for example, as antagonists to the mu, kappa and delta opioid receptors, and thereby may be useful in the treatment of gastrointestinal motility disorders, and in preventing peripheral opiate induced side effects. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.
Type:
Grant
Filed:
August 8, 2002
Date of Patent:
September 21, 2004
Assignee:
Adolor Corporation
Inventors:
Bertrand Le Bourdonnec, Roland Ellwood Dolle