Abstract: The process for producing polyesters, and in particular, polyethylene terephthalate (PET) which includes the use of antimony catalyst that is acidic phosphorus additive involves the addition of the catalyst prior to or together with the additive. Moreover, the amount of additive is selected so as to provide a resin that is at least substantially free of non-acidic inorganic compounds such as antimony phosphate which can be formed by the reaction of the catalyst with the additive. The process preferably includes an esterification step, a prepolymer step, and a polymerization step with the antimony catalyst being added prior to, during, or after, the esterification step while the phosphorus-containing additive is introduced prior to or during the prepolymer stage. Polyesters having low levels of elemental phosphorus are also disclosed.

Abstract: A method for promoting growth in fish comprising administering a low level dosage amount of zearalanol to fish. The zearalanol may be conveniently administered to the fish via a novel fish feed formulation comprising a conventional feed mixture supplemented with a relatively low dosage amount of zearalanol ranging from 1 to 20 parts per million (ppm) zearalanol in the feed. In another embodiment, the zearalanol may be administered to the fish in the form of a novel complex of zearalanol and a cyclodextrin compound which further enhances the growth process.

Abstract: The present invention relates to compositions for the sustained release of drugs and to methods for the production of such compositions. In one embodiment, somatotropin is layered onto non-pareil seeds, which, in turn are sprayed with a glycine solution. Next, a coating of a wax mixture is applied.

Abstract: Monoclonal antibodies are provided which differentiate between native and modified sequence proteins. Also provided are methods for using monoclonal antibodies to determine the relative amount of native and modified sequence proteins in a sample.

Abstract: A controlled release delivery device for macromolecular proteins which comprises a water-soluble outer capsule completely surrounding an inner compartment containing a plurality of non-uniform beadlets. The beadlets comprise a rupturable wax shell which completely surrounds a core matrix containing the macromolecular proteins and optional "core agents" such as excipients, stabilizers, binders, surfactants, preservatives, or mixtures thereof, and the like.The water-soluble outer capsule dissolves when the device is administered to an animal and simultaneously exposes substantially all of the beadlets to an aqueous environment. Each beadlet absorbs fluid from the environment and separately ruptures over a prolonged period thus delivering the macromolecular protein to the animal.

Abstract: Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [Pro.sup.0, X.sup.15, Y.sup.27 ]-hGRF(1-A)-B, wherein X is selected from the group consisting of Ala and Gly, Y is selected from the group consisting of Ile, Leu, Val, Nle and Met, A has a value from 29-44, and B is NH.sub.2, OH or COOH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).

Abstract: Porcine somatotropin (pST) and dietary lysine are administered in combination in dosages of from about 1-20 mg/swine/day pST and from about 0.9-1.6% by weight dietary lysine to synergistically promote growth, improve weight gain and increase feed utilization efficiency in swine. Administration of the compounds is conveniently accomplished by (1) administering porcine somatotropin (pST) to swine using conventional methods such as injections or implants and (2) feeding the swine a feed composition containing the lysine.

Abstract: The present invention provides a stable and bioactive somatotropin which has its small-loop sulfhydryl groups derivatized and a method for producing the small-loop derivatized somatotropin. The small-loop derivatized somatotoropin is stable during long term storage, i.e. it forms very few dimers, oligomers, and aggregates which inactivate the somatotropin, and has a bioactivity equal to or greater than that of the non-derivatized somatotropin.

Abstract: High titers of polyether antibiotics are obtained in a fermentation broth by inoculating a nutrient fermentation broth with a microorganism capable of producing a polyether antibiotic. Growth of the microorganism is established in the broth by incubating the inoculated broth at a physiologically acceptable temperature until pH of the broth begins to rise upon establishment of growth of the microorganism. A free fatty acid then is fed into the broth to achieve and maintain a free fatty acid concentration in the broth of about 0.1% by weight or greater but less than a level at which the free fatty acid is toxic to the microorganism. The free fatty acid is fed into the broth during the remainder of fermentation at about a rate at which the free fatty acid is consumed by the microorganism, to product high titers of the polyether antibiotic.

Abstract: An aqueous medium having dispersed therein hydrophobic, polyether antibiotic-containing droplets, is mixed to cause the droplets to collide with each other and coalesce to form agglomerates which are separable from the medium.

Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight contaminating proteins by directly adding a flocculant to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants is disclosed.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.

Abstract: Polyether antibiotic material is liberated from agglomerates containing a lipid material and the polyether antibiotic material by separating the polyether antibiotic from the lipid through formation of an acid salt of the lipid and a desired acid salt of the polyether antibiotic. The agglomerates can be formed during fermentation or produced by adding lipids afterwards.

Abstract: A method for preventing conception in mammals which includes administering to the mammals a composition containing (1) free LHRH or its analog and (2) an immunogenic conjugate between LHRH or its analog and a carrier protein. Free LHRH or its analog acts to prevent conception in the mammal during the period from administration to about 6 weeks; the immunogenic conjugate acts to prevent conception during the period from about 6 weeks after administration until the LHRH antibodies formed in response to the conjugate are metabolized, generally about 0.5-2 years.

Abstract: A method of producing a high purity silica powder which can be fused to form transparent, bubble-free particles. An ammonium fluosilicate solution is purified preliminarily by removing colloidal-sized silica onto which impurities in the solution have been adsorbed. The high purity powder is produced by ammoniation of an unsaturated aqueous solution of ammonium fluosilicate. Silica powder produced is filtered, washed, and dried before fusion. Additional pre-fusion treatments such as washing, hydrothermal leaching, calcination, and a combination thereof, may be utilized to ensure that the concentration of volatile material is low.

Abstract: High purity fused silica particles are made by heating relatively low density silica flour in a high temperature flame. The silica flour feed rate, flame temperature, and collection zone temperature are adjusted to produce an aggregate of surface-bonded fused silica particles. The aggregate is shaped like a honeycomb and can be ground autogenously without introducing impurities into the final product.

Abstract: A pelletized feed supplement is supplied which effectively increases productivity of animals fed high acid producing diets. The pelletized feed supplement can also be used to neutralize stomach acid of humans and to maintain a proper electrolyte balance. A method is taught of producing the pelletized feed supplement which results in a buffering agent which is dissolved gradually, and has a high buffering capacity.

Abstract: The known immunostimulants FK-565 and IL-2 are administered to animals in conjunction to synergistically stimulate the immune system.

Abstract: Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are useful for controlling coccidiosis in poultry.

Abstract: Substituted resorcyclic acid esters having the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R.sub.3 is an alkyl group having from 1-12 carbon atoms are synthesized and used as housefly chemosterilants which reduce housefly fecundity.

Abstract: A new method for preparing low loss multimode and monomode glass optical fibers which avoids casting or pouring the core and clad melts is disclosed. The new technique is based on a reactive-gas-transport approach which avoids contamination from absorbing impurities and scattering centers by reacting the glass melt with reactive gases which remove impurities and increase the refractive index of the fiber.