Abstract: The present invention relates to the use of an angiotensin II type 1 receptor antagonist of the general formula (I) in the manufacture of a medicament for the prophylactic and/or therapeutic treatment of a vascular headache condition such as migraine, in a subject suffering from, or susceptible to, such a vascular headache condition. A further aspect of the invention is a pharmaceutical formulation useful in any one of said vascular headache conditions, as well as a method of treatment thereof.

Abstract: The present invention relates to systems, methods, data structures and user interfaces for generating and presenting information as to how and why the book yield of an investment portfolio changed over a time interval. Dynamic book yield analysis is particularly useful for bond portfolio analysis and management. Transactions and events that occur in a financial market during a pre-specified time period and relating to a portfolio of assets are identified by a computer server. Specifically, the book yields and book values for these transactions and events are accessed from the portfolio accounting system and the data for each transaction/event are categorized according to transaction/event type (though net cash equivalents are first separated out into their own category). The categorized information is then stored in a data structure residing on the system.

Abstract: The present invention relates to a novel method to determine the ratio of 5-methoxy and 6-methoxy isomers of omeprazole present in a mixture thereof. The method uses different Raman scattering efficiency values for the 5-methoxy and 6-methoxy isomers. This is of importance since the two isomers have different stability in the solid state in bulk form and in admixture with pharmaceutical excipients.

Abstract: A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.

Abstract: The present invention provides an electrical depilator comprising substantially of a main body, a motor, a reduction gear set, an arcuate shaft and a set of single-pieces. The arcuate shaft is supported on a shaft seat of the main body. A first stage gear of the reduction gear set meshes with the driving wheel of the motor, and a last stage gear is fixed on the single-piece which is located at the endmost portion. Each single-piece has a clipping surface and a supporting portion. The whole set of single-pieces are arranged in a manner that the clipping surfaces are opposite to each other. A clipping gap is formed between opposite surfaces of two single-pieces. The whole set of single-pieces are coupled together by fixing members so as to rotate synchronously. The whole set of single-pieces are fitted over the arcuate shaft all together. The electrical depilator is easy in die sinking, convenient in assembling, and of low cost.

Abstract: A film coating composition suitable for use in coating pharmaceutical formulations to provide modified release comprising a dispersion which includes: a) an acrylic polymer, b) a vinyl acetate polymer, and c) a water-containing liquid. The film coat is useful for the achievement of modified release from pharmaceutical formulations such as tablets, pellets, etc.

Abstract: The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). The compounds are represented by the general formula (I) wherein R1, R2, R3 and R4 are as defined in the description. For example, R1 may be phenyl, R2 may be dimethylamino pyrrolidin-1-yl, R3 may be alkoxy and R4 may be alkyl, ai arylalkyl, aryloxyalkyl, aryloxy or heterocyclylalkyl.

Abstract: Novel compounds of formula I, with the exception of i) the racemate of (3-amino-2-hydroxypropyl)phosphinic acid; and ii) (2R/S, 3R)-(3-amino-2-hydroxybutyl)phosphinic acid, having affinity to one or more GABAB receptors, their pharmaceutically acceptable salts, solvates and stereoisomers, as well as processes for their preparation, pharmaceutical compositions containing said therapeutically active compounds and the use of said active compounds in therapy.

Abstract: According to the invention, a tool holder system having a tool holder with an extension and retraction device, in particular a reel, by means of which a cable, to which a tool can be fastened, is extendable and automatically retractive, is characterized by the fact that the tool holder can be detachably fastened by means of an attaching device.

Abstract: A method of making a lead frame and a partially patterned lead frame package with near-chip scale packaging (CSP) lead-counts is disclosed, wherein the method lends itself to better automation of the manufacturing line as well as to improving the quality and reliability of the packages produced therefrom. This is accomplished by performing a major portion of the manufacturing process steps with a partially patterned strip of metal formed into a web-like lead frame on one side, in contrast with the conventional fully etched stencil-like lead frames, so that the web-like lead frame, which is solid and flat on the other side is also rigid mechanically and robust thermally to perform without distortion or deformation during the chip-attach and wire bond processes, both at the chip level and the package level. The bottom side of the metal lead frame is patterned to isolate the chip-pad and the wire bond contacts only after the front side, including the chip and wires, is hermetically sealed with an encapsulant.

Abstract: A system and method for authentication including verifying a password is disclosed. In one embodiment, the authentication system includes a first storage unit to store an authentication sequence and a read-only memory unit to store an authentication algorithm. A microcontroller is coupled to the first storage unit, the read-only memory unit, and is configured to be coupled to and uncoupled from a host. The microcontroller is configured to execute the authentication algorithm to verify a password with the authentication sequence, and to send an access request to a web server via the host if the authentication algorithm has verified the password with the authentication sequence.

Abstract: A method of making a lead frame and a partially patterned lead frame package with near-chip scale packaging lead-count, wherein the method lends itself to better automation of the manufacturing line and improved quality and reliability of the packages produced therefrom. A major portion of the manufacturing process steps is performed with a partially patterned strip of metal formed into a web-like lead frame on one side so that the web-like lead frame is also rigid mechanically and robust thermally to perform without distortion or deformation during the chip-attach and wire bond processes, both at the chip level and the package level. The bottom side of the metal lead frame is patterned to isolate the chip-pad and the wire bond contacts only after the front side, including the chip and wires, is hermetically sealed with an encapsulant. The resultant package being electrically isolated enables strip testing and reliable singulation.

Abstract: A process for the preparation of a dispersion of crystalline nanoparticles in an aqueous medium is disclosed. Specifically, a first solution comprising a substantially water-insoluble substance in a water-miscible organic solvent is rapid mixed with an aqueous phase comprising water, and optionally a stabilizer, to form a dispersion of amorphous particles. The dispersion of amorphous particles is then sonicated for a sufficient period to form crystalline nanoparticles of the substantially water-insoluble substance. The process provides nanocrystals with a mean hydrodynamic diameter of less than 1 micron, particularly less than 300 nm, and is particularly useful for the preparation of nanocrystalline dispersions of pharmaceutical substances.

Abstract: A control system for a first window lifter adjusts a first window pane of a motor vehicle having a first drive, and for a second window lifter for adjusting a second window pane of the motor vehicle having a second drive, having a control device. The control device may be electrically connected both to the first drive and to the second drive for the purpose of energization. The control device may have a first sensor for determining a first adjustment position of the first window lifter, and a second sensor for determining a second adjustment position of the second window lifter, the first sensor and the second sensor being based on different physical operational principles.

Abstract: The present invention relates to a novel form of the (?)-enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole, i.e. S-omeprazole. More specifically, it relates to a novel form of the magnesium salt of the S-enantiomer of omeprazole trihydrate. The present invention also relates to processes for preparing such a form of the magnesium salt of S-omeprazole and pharmaceutical compositions containing it. Furthermore, the present invention also relates to new intermediates used in the process.

Abstract: The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). The compounds are represented by the general formula (I) wherein R1, R2, R3 and Y are as defined in the description. For example, R1 may be phenyl, R2 may be dimethylamino, R3 may be alkoxy and Y may be a thioylamino- or methyl eneamino- linked substitutuent containing an aryl group.

Abstract: A control apparatus for an adjusting device in a motor vehicle is provided. The apparatus has a sensor, particularly a current sensor (S1), for generating a signal (U1 to U10, I1 to I3, ?t1 to ?t8) which is dependent on a motor movement by a motor in the adjusting device. The apparatus also has a power driver for controlling a motor current, and a processor (RE). The processor is designed and set up (i) to find a position (xm) from the sensor signal (U1 to U10, I1 to I3, ?t1 to ?t8), particularly from the ripple in the motor current, (ii) to associate a reference characteristic (Chref) of orderly signals (U1 to U10, I1 to I3, ?t1 to ?t8) from the sensor, particularly for the ripple, with a reference position (xref), (iii) to correct the position found (xm) on the basis of the reference characteristic (Chref) and the reference position (xref), and (iv) to control the motor current on the basis of the corrected position.

Abstract: A communication system for use in entertainment games comprises a server accessible by a plurality of game users via a mobile communications network. The server is configured to request the availability of first data, preferably correlated to money, from game users and facilitates real-time communication between users. The server allows a user to correlate its first data to the result of a comparison made during game play and is configured to automatically compare second data entered by users to determine the result. Preferably, the second data is dependent on and/or affected by the physical and/or intellectual skill of the user. The result may also be affected by random parameters, communicated to the users as instant tickets prior to the start of game play. Based on the result, the server automatically distributes the first data to users according to the result and the correlation of the first data to the result.

Abstract: The present invention relates to novel compounds having a positive allosteric GÀBAB receptor (GDR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). A compound of the general formula I.

Abstract: The present invention relates to imidazopyridine derivatives of the Formula I and, therapeutically acceptable salts thereof which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the treatment of gastrointestinal inflammatory diseases. In further aspects, the invention relates to the compound of the invention for use in therapy; to processes for preparation of such new compound; to pharmaceutical compositions containing the compound of the invention, or a therapeutically acceptable salt thereof, as active ingredient; and to the use of the compound of the invention in the manufacture of medicaments for the medical use indicated above.