Abstract: A method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination of
a) a 2-(5-phenyl-3,6-diaza-2,7-dioxa-octa-3,5-dienyl)phenylacrylamide of formula I
wherein
R1 is hydrogen, fluoro or chloro,
R2 is methyl, ethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro or bromo, with the proviso that R2 cannot be fluoro, chloro or bromo, when R1 is hydrogen;
in association with
b) a broad variety of otherplant fungicides is particularly effective in combating or preventing fungal diseases of crop plants. These combinations exhibit synergistic fungicidal activity.
Type:
Grant
Filed:
February 28, 2000
Date of Patent:
May 22, 2001
Assignee:
Novartis Crop Protection, Inc.
Inventors:
Gertrude Knauf-Beiter, René Zurflüh, Bettina Gsell
Abstract: If the R-enantiomer of metalaxyl, furalaxyl or benalaxyl is used, this results in a markedly increased biodegradability of these plant fungicides in the soil and a higher activity on the plants, as compared with the data of the racemic active ingredients. Fungicidal compositions exhibiting said improved properties comprise either of these fungicides with a content of R-enantiomer of more than 70 percent by weight based on the total amount of active ingredient.
Type:
Grant
Filed:
October 19, 1998
Date of Patent:
May 8, 2001
Assignee:
Syngenta Investment Corporation
Inventors:
Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi, Holm Ellgehausen
Abstract: An agrochemical composition, comprising at least two active ingredient components together with a suitable carrier, wherein component I is
I) difenoconazole (=cis,trans-3chloro-4-[4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl]phenyl 4-chlorophenyl ether) and wherein component II is
IIA) fluquinconazole (=3-(2,4-dichlorophenyl)-6-fluoro-2-(1H-1,2,4-triazol-1-yl)quinazolin) or
IIB) 4,5-dimethyl-N-2-propenyl-2-(trimethylsilyl)-3-thiophencarboxamid which is especially suitable in the control and prevention of disease infestation on seed.
Abstract: A process for the preparation of a compound of formula I
wherein R1 is selected from the group consisting of —CO2CH3, —CON(CH3)2, —OCH2CF3, —N(CH3)COCH3, —N(CH3)SO2CH3, —CF3, and —SO2C2H5;
R2 is selected from the group consisting of hydrogen and —CF3; and
M is selected from the group consisting of sodium and potassium;
comprising: reacting a compound of formula IV
in an aprotic, organic solvent with a compound of formula V
wherein R1, R2, and M are as defined above.
Abstract: Reaction products of an iridium(III) salt or a hydrate thereof, a diphosphine having secondary phosphine groups and a metal or ammonium chloride, bromide or iodide are excellent hydrogenation catalysts for ketimine. Using chiral diphosphines and prochiral ketimines, diastereoisomeric secondary amines are obtained in high optical yields.
Abstract: The invention relates to a process for preparing a compound of formula (I), in which X is CH or N, Y is NO2 or CN, Z is CHR3, O, NR3 or S, R1 and R2 are either each, independently of the other, hydrogen or unsubstituted or R4-substituted alkyl or together a two- or three-membered alkylene bridge or a two- or three-membered alkylene bridge in which one member is replaced by a hetero member selected from the group, consisting of NR5, O and S, R3 is H or unsubstituted or R4-substituted alkyl, R4 is an unsubstituted or substituted aryl or heteroaryl group, and R5 is H or alkyl, which comprises a) reacting a compound of formula (II) with a chlorinating agent or b1) initially reacting a compound of formula (IV) with a compound of formula (V) and b2) further reacting the compound of formula (II) obtainable thereby, with or without intermediate isolation, with a chlorinating agent, to intermediates used in this process, to the use of these intermediates and to a process for the preparation of these intermediates.
Type:
Grant
Filed:
June 1, 1998
Date of Patent:
April 3, 2001
Assignee:
Novartis Crop Protection, Inc.
Inventors:
Henry Szczepanski, Thomas Göbel, Ottmar Franz Hüter, Anthony Cornelius O'Sullivan, Marcel Senn, Thomas Rapold, Peter Maienfisch, Thomas Pitterna
Abstract: Aryl- or heteroaryluracils of formula I
wherein R1 signifies methyl or ethyl; R2 signifies —CF3, —CClF2, —CCl2F, or —C2F5; and Q is an aryl or heteroaryl group; are produced whereby a compound of formula II
O═C═N—Q (II)
is reacted at a temperature of −5° C. to +40° C. with an enamine of formula III
wherein R19 signifies C1-C6-alkyl, in the presence of a solvent and of 0.1 to 0.4 equivalents of a base with respect to the employed enamine of formula III. The compounds of formula I are useful as herbicides. An example of the compounds of formula I is 2-chloro-5-(3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1-(2H)pyrimidinyl)-benzoic acid 1-aalyloxycarbonyl-1-methyl-ethyl-ester.
Abstract:
Compounds of formula (I) in which A is ═N— or (a); W is a group (W1), (W2) or (W3); R11 is hydrogen, fluorine, chlorine, bromine or methyl; and R1 to R5, R13,n1 and n13 are as defined in claim 1, and the pyrazole N-oxydes, agrochemically tolerated salts and stereoisomers of these compounds of formula (I), have good pre- and post-emergent selective herbicidal properties. The preparation of these compounds and their use as herbidical active substances are described.
Type:
Grant
Filed:
May 7, 1999
Date of Patent:
March 20, 2001
Assignee:
Syngenta Crop Protection, Inc.
Inventors:
Kurt Nebel, Hans-Georg Brunner, Rolf Schurter
Abstract: &agr;-Amino acid amides of formula (I) wherein the substituents are defined as follows: n is a number zero or one; R1 to R7 are as defined herein; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9 is C3-C8cycloalkyl; a C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl group substituted by one or more halogen atoms; or a group (a) wherein p and q are identical or different and are each independently of the other a number zero or one; and R13, R14, R15 and R16 are identical or different and are each independently of the others hydrogen or C1-C4alkyl; X is hydrogen, in which case p and q must have the value zero; phenyl, unsubstituted or mono- or poly-substituted by halogen, nitro, cyano, carboxy, C2-C6alkenyl, C2-C6alkenyl, C1-C6haloalkyl, C3-C6alkenyloxy, C3-C6alkynyloxy, C3-C7cycloalkyl, C1-C6haloalkoxy, C1-C6alkylthio, C1-C6alkoxycarbonyl, C3-C6alkenyloxycarbonyl, C3-C6alkynyloxycarbonyl, C1-C6or by C1-C6alkoxy, cyano, —COOR17; —COR18 or a group (b) wherein R17 and R21 are each independently of the other
Abstract: &agr;-Amino acid amides of formula (I) wherein the substituents are defined as follows: n is the number zero or one; R1 to R7 are as herein defined; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9 is C3-C8cycloalkyl; a C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl group substituted by one or more halogen atoms; or a group (a) wherein p and q are identical or different and are each independently of the other the number zero or one; and R13, R14, R15 and R16 are identical or different and are each independently of the others hydrogen or C1-C4alkyl; and X is hydrogen, in which case p and q must have the value zero; phenyl unsubstituted or mono- or poly-substituted by halogen, nitro, cyano, carboxy, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C3-C6alkenyloxy, C3-C6alkynyloxy, C3-C7cycloalkyl, C1-C6haloalcoxy, C1-C6alkylthio, C1-C6alcoxycarbonyl, C3-C6alkenyloxycarbonyl, C3-C6alkynyloxycarbonyl, C1-C6alkyl or by C1-C6alkoxy; cyano; —COOR17; —COR18 or a group (b) wherein R17 and R21 are each independently
Abstract: A method for treating or preventing mastitis in mammals is disclosed. The method contemplates the intramammary injection or dipping the teat with micrococcin antibiotics, preferably micrococcin P1 or P2, which do not interfere with the production of cheese and yoghurt using milk from treated animals. Hydrophobic antibiotics such as micrococcin P1 or P2 can be administered prior to infection to effectively suppress the rate, severity, and duration of subsequent bacterial infection, or can be administered subsequent to infection to effectively treat mastitis.
Type:
Grant
Filed:
December 18, 1998
Date of Patent:
February 13, 2001
Assignee:
Novartis Animal Health U.S., Inc.
Inventors:
Bruno Suri, Catherine Georges, John Edmondson Peel
Abstract:
The invention relates to a process for preparing a compound of formula (I) in which A is chlorine or 3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazin-5-yl; to intermediates used in this process; to the use of these intermediates; and to a process for the preparation of these intermediates. The compounds of formula (I) are valuable intermediates in the process of preparing pesticidal, especially insecticidal or acaricidal, formulations.
Abstract: A herbicidal composition comprising, in addition to conventional inert formulation adjuvants, the compound of formula I
in admixture with a synergistically effective amount of at least one active ingredient from the substance classes of formula IV
e.g., glyphosate or glufosinate.
Type:
Grant
Filed:
January 26, 1998
Date of Patent:
January 30, 2001
Assignee:
Novartis Crop Protection, Inc.
Inventors:
Willy R{umlaut over (u)}egg, Manfred Hudetz
Abstract: (R)(+)-2-[4-(5-chloro 3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid propinyl ester is produced by converting a compound of formula II
in an inert organic solvent, without isolation of the intermediate products, with M2CO3, in which M is sodium or potassium, into the compound of formula III
reacting this with the compound of formula IV
to form the compound of formula V
and converting this with a compound of formula VI
wherein Z signifies phenylsulphonyl, tosyl, methylsulphonyl, nosyl, bromophenyl, Cl-, Br- or CICO-, into the compound of formula I.
Type:
Grant
Filed:
March 16, 1999
Date of Patent:
January 16, 2001
Assignee:
Novartis Crop Protection, Inc.
Inventors:
Gottfried Seifert, Andrea Rolf Sting, Bernhard Urwyler
Abstract: A selective herbicidal composition for controlling grasses and weeds in crops of cultivated plants, comprising a) a herbicidally effective amount of a herbicide of formula I ##STR1## and b) to antagonise the herbicide, an antidotally effective amount of a safener selected from the group of the compounds of formula 1.01 (CGA 185,072), 2.01, 2.05, 3.03, 4.001, 5.006 (benoxacor), and 6.02 (fluxofenim).
Abstract: A herbicidal composition comprising a compound of formula A ##STR1## or an agrochemically acceptable salt thereof and at least one compound from the substance classes of formulae I-VII.
Abstract: The invention relates to a process for the preparation of compounds of the formula ##STR1## or, if appropriate, a tautomer thereof, in each case in the free form or in salt form, in whichA, X, Y, Z, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7, R.sub.9 and n are as defined in claim 1 and the C.dbd.N double bond marked with E has the E configuration, which comprisesa1) reacting either a compound of the formula (II) mentioned above with a compound of the formula (III) mentioned above, in which X.sub.1 is a leaving group, ora2) a compound of the formula (IV) mentioned above, if appropriate in the presence of a base, with a compound of the formula (V) mentioned above, orb1) reacting a compound of the formula (VI) mentioned above with a compound of the formula R.sub.7 --A--X.sub.2 (VII), in which X.sub.
Type:
Grant
Filed:
December 6, 1996
Date of Patent:
December 5, 2000
Assignee:
Novartis Corporation
Inventors:
Saleem Farooq, Stephan Trah, Hugo Ziegler, Rene Zurfluh
Abstract: The invention relates to the compounds of Formula XA ##STR1## wherein X and Y represent independently hydrogen, fluorine or chlorine, Z.sub.1 is fluorine or chlorine and M is hydrogen or a salt forming moiety and Z.sub.2 ' is chlorine or fluorine; and the corresponding herbicidal composition and methods of use. The compounds of the invention are useful as auxin transport inhibitors (i.e. useful as herbicides) and useful as potentiators or enhancers of herbicides.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
December 5, 2000
Assignee:
Novartix AG
Inventors:
Richard J. Anderson, Ian S. Cloudsdale, Robert J. Lamoreaux, Kristine J. Schaefer, Jost Harr
Abstract: Compounds of formula (I) and their possible isomers and isomer mixtures, in which (Z) is a group (a), (b), (c) or (d) and in which the other substituents are as defined herein.
Abstract: This invention relates to fungicidal active ingredient mixtures comprising at least two active ingredient components together with a suitable carrier material, wherein component I is cyprodinil [=2-anilino-4-cyclopropyl-6-methyl-pyrimidine] and wherein component II is A) myclobutanil [=2-p-chlorophenyl-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile]; or B) iprodione [=3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide] , and to methods of using such mixtures in crop protection, especially in the control and prevention of disease infestation.