Abstract: Novel inhibitors of metalloproteases, in particular collagenase-1 and stromelysin-1, are disclosed. Such compounds are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, such as rheumatoid arthritis.
Type:
Grant
Filed:
July 9, 1999
Date of Patent:
August 7, 2001
Assignee:
Affymax Technologies, N.V.
Inventors:
David Campbell, Gary C. Look, Anna Katrin Szardenings, Dinesh V. Patel
Abstract: Compositions and methods for the solid phase synthesis of organic compounds are provided. The compositions are solid supports having an attached traceless linker precursor and are represented by the formula: ##STR1## In this formula, S.sup.0 is a solid support; B is a connecting group; M is a transition metal, for example ruthenium, chromium, iron, molybdenum and manganese; each L is independently a transition metal ligand; the letter n represents an integer of from 1 to 4, such that M has a sufficient number of ligands to fill the available valences; and X.sup.- represents an anion which is typically a non-nucleophilic anion.
Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
Type:
Grant
Filed:
July 18, 1997
Date of Patent:
March 9, 1999
Assignee:
Tularik Inc.
Inventors:
Julio Cesar Medina, David Louis Clark, John A. Flygare, Terry J. Rosen, Bei Shan
Abstract: Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, .beta.-turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.