Abstract: Compounds of the formula ##STR1## which have antifungal activity.

Abstract: Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.-and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy--or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.

Abstract: An analytical device separates magnetic microparticles from a suspension. The separating portion of the device contains two permanent magnets between which the reaction vessel containing the suspension is disposed. For the purpose of more rapid, complete separation of the magnetic microparticles, magnets are positioned diametrically opposite one another relative to the reaction vessel. The polar axes of the magnets and the longitudinal axis of the reaction vessel include an acute angle.

Abstract: A vessel holder for receiving a number of vessels is useful in an automated analyzer. To increase the number of vessels which can be received in the analyzer and to simplify the device for reading bar code labels, the vessel holder has an elongate body manufactured in one piece and containing a single straight row of identical elongate chambers. Each chamber is for receiving one vessel. All chambers have a common base with respect to which they are perpendicularly disposed. Adjacent chambers are separated by a partition. The inside of a side wall of each chamber bears a first bar code label for detecting the absence of a vessel in the chamber, and the outside of a side wall of each chamber bears a second bar code label for detecting the position of the chamber in the vessel holder. The first and the second bar code labels are readable by a bar code reader from one and the same side of the vessel holder.

Abstract: The invention provides an immunogenic polypeptide having the amino acid sequence ##STR1## and fragments thereof, which polypeptides are capable of inducing an immune response against Eimeria parasites, and the DNA encoding such polypeptides, as well as recombinant vectors and recombinant viruses containing the said DNA or fragments thereof and transformed microorganisms containing such vectors and viruses and coccidiosis vaccines comprising such polypeptides.

Abstract: Colors are generated in the display device by guiding light through three serially-arranged, electrically controlled color filters. Each filer attenuates one of three colors. The color filters incorporate two cholesteric filters, two .lambda./4 plates, and one electrically switchable liquid crystal display.

Abstract: A process for producing a compound having the formula ##STR1## wherein X is halogen and R.sup.1 is lower alkyl, benzyl, or phenyl, which comprises reducing a compound having the formula ##STR2## wherein X and R.sup.1 are as above, with an aluminum trialkoxide or lithium aluminum trialkoxyhydride reducing agent.

Abstract: An analyzer automatically performs analytical operations in which liquid samples for analysis and required reagents are held in suitable vessels. To increase the number of vessels which can be received in the analyzer and to simplify the device for reading the bar code labels, the analyzer contains at least two vessel holders, a bar code reader, and means for automatically adjusting the focal range and the bar code reader. The vessel holders are disposed parallel to one another in the analyzer. A number of vessels of the same kind (for example, sample-containing vessels) are disposed in each vessel holder. Each vessel holder has an elongate body manufactured in one piece and contains a single straight row of identical elongate chambers for receiving one vessel. All chambers have a common base and are disposed perpendicularly thereto. Adjacent chambers are separated by a partition.

Abstract: Compounds containing a (4,5)-cis-2-oxo-oxazolidine ring are isomerized to the corresponding (4,5)-trans-2-oxo-oxazolidine by treating the cis compound with a strong base.

Abstract: Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.- and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy- or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.

Abstract: Compounds of the following formula are useful as liquid crystals: ##STR1## wherein R is a C.sub.1 -C.sub.12 alkyl or a C.sub.2 -C.sub.12 alkenyl;A is a single bond or trans-1,4-cydohexylene;Z.sup.1 and Z.sup.2 are independently a single bond or --CH.sub.2 CH.sub.2 --, except Z.sup.1 and Z.sup.2 cannot simultaneously be --CH.sub.2 CH.sub.2 --;ring B is trans-1,4-cyclohexylene or 1,4-phenylene; andn is 0 or 1,Liquid crystalline mixtures which contain such compounds are especially useful in electro-optical indicating devices.

Abstract: This invention provides DNA sequences coding for Eimeria surface antigens, recombinant vectors containing such DNA sequences, transformed microorganisms containing such vectors, and methods for producing the antigens using the transformed microorganisms. Methods are also provided for protecting poultry against coccidiosis using the Eimeria surface antigens. The surface antigens can be administered for such protection either as purified proteins or in the form of DNA encoding the proteins in a suitable viral vector such as vaccinia virus.

Abstract: It is an object of this invention to provide a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof characterized in that the TNF sequence is changed by a deletion, insertion, substitution or combinations thereof, of one or more amino acids so that the mutein shows a significant difference between its binding affinity to the human p75-Tumor-Necrosis-Factor-Receptor and to the human p55-Tumor-Necrosis-Factor-Receptor. The invention also includes DNA sequences coding for such muteins, vectors comprising such DNA sequences, host cells transformed with such vectors and a process for the production of such muteins employing such transformed host cells and pharmaceutical compositions containing such muteins and their use for the treatment of illnesses, for example cancer.

Abstract: The present invention is concerned with optically active, ferroelectric, smectic, photo-cross linkable compounds of the formula ##STR1## wherein A.sup.1 and A.sup.2 may both signify residues of the formula ##STR2## and be the same or different, while A.sup.3 may signify a residue of the formula ##STR3## as well as liquid crystalline mixtures which contain such compounds and their use in the cross-linked state in optical components.

Abstract: A novel process for the manufacture of .beta.-keto alcohols from aldehydes comprising reacting a conjugated polyene aldehyde under basic conditions with a cyclocarbonate or derivative thereof. Certain carotenoid products of this process are novel compounds and are also an object of the present invention. The products, which for the most part belong to the carotenoid field, find corresponding use, for example, as colorants or pigments for foodstuffs, egg yolk, integuments and/or subcutaneous fat of poultry and flesh and/or integuments of fish and crustaceans.

Abstract: Methods are provided for the replication and amplification of RNA sequences by thermoactive DNA polymerases. In a preferred embodiment, high temperature reverse transcription is coupled to nucleic acid amplification in a one tube, one enzyme procedure using a thermostable DNA polymerase. Methods for eliminating carry over contamination of amplifications due to prior reverse transcription reactions are also provided.

Abstract: The invention relates to a process for the preparation of liposomes or proliposomes in which a mixture suitable for their preparation is milled in an agitator-ball mill.

Abstract: An apparatus for automatic performance of temperature cycles in a number of test tubes in which each test tube is closed by a closure and contains a predetermined volume of a liquid reaction mixture. The apparatus includes a holder, a computer-controlled automatic control system, and a device for cyclic alteration of the holder temperature. The holder has an arrangement of chambers for holding test tubes with each chamber being adapted to receive one test tube. The holder is constructed of a material of high thermal conductivity, and has an upper surface, a bottom surface and a cylindrical outer wall. Each chamber has an opening located in the upper surface of the holder. The device for cyclic alteration of the temperature of the holder is actuated by the automatic control system. By reducing the dimensions of the device and the power required to operate it, numerous advantages are realized.

Abstract: The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

Abstract: A method of pigmenting certain parts and products of poultry, fish and crustacea by including in the feed of the pertinent animal one or more of the carotenoids 2'-dehydroplectaniaxanthin, desmethylspheroidenone, spheroidenone, 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-caroten-6'-one, 1'-hydroxy-3',4'-didehydro-1',2'-dihydro-.beta.,.psi.-carotene-4,2'-dione and 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-carotene-4,6'-dione, poultry, fish and crustacea feeds for pigmenting certains parts and products of these animals, beadlets and premixes for adding to poultry, fish and crustacea feeds, and the carotenoids 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-caroten-6'-one, 1'-hydroxy-3',4'-didehydro-1',2'-dihydro-.beta.,.psi.-carotene-4,2'-dione and 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-carotene-4,6'-dione.