Abstract: An endometrial sampler is provided for obtaining an endometrial sample for clinical analysis which is safe to use and reduces patient discomfort. The sampler includes a handle and a flexible plastic probe having grooves on diametrically opposite sides adjacent the distal end of the probe. Each groove has a pair of sharp edges with each edge formed at the intersection of the periphery of the probe and a sidewall of the groove with the two forming an acute angle at their intersection. The probe is of solid plastic, relatively small in diameter and can be bent before insertion into the uterus of a patient to reduce patient discomfort.