Patents Represented by Attorney, Agent or Law Firm William T. Han
  • Patched-2 polypeptide
    Patent number: 6353092
    Abstract: Patched-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Patched-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: March 5, 2002
    Assignee: SmithKline Beecham plc
    Inventors: David P Kelsell, Michael R Barnes, Tania Tamson Testa
  • Human sodium dependent phosphate transporter (IPT-1)
    Patent number: 6350858
    Abstract: IPT-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IPT-1 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, end stage renal disease, uremic bone disease, and cancer, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: John Feild
  • Cytokine suppressive anti-inflammatory drug binding protein
    Patent number: 6350856
    Abstract: p38beta2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Sanjay Kumar
  • Human urotensin II
    Patent number: 6348585
    Abstract: Human Urotensin II polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human Urotensin II polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: February 19, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jeffrey Culp, Catherine E Ellis, Dean E McNulty
  • Method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2
    Patent number: 6346388
    Abstract: The present invention relates to tumor necrosis factor receptor (TNF-R) related polypeptides and their ligands, hereinafter referred to as TR1, TR2, TL2 and TL4. The invention relates to methods to identify agonists and antagonists of TR1, TR2, TL2 and TL4.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: February 12, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael R. Brigham-Burke, Peter R. Young
  • Human EDG3sb gene
    Patent number: 6344542
    Abstract: The EDG3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EDG3sb polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: February 5, 2002
    Assignee: Smithkline Beecham Corporation
    Inventor: Ping Tsui
  • Human G protein coupled lysophosphatidic acid receptor
    Patent number: 6344342
    Abstract: HOFNH30 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOFNH30 polypeptides and polynucleotides in terapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: February 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Ping Tsui, Catherine E. Ellis, Ganesh M. Sathe, Stephanie Van Horn, Robert S. Ames, James J. Foley, Laura R. Fitzgerald, Henry M. Sarau, Jonathan K. Chambers
  • Human protein kinases hYAK3-2
    Patent number: 6323318
    Abstract: hYAK3-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: November 27, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Kenneth A. Lord, Susan B. Dillon, Caretha Creasy
  • Mouse EDG1
    Patent number: 6323333
    Abstract: EDG1 (mouse) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EDG1 (mouse) polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: November 27, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Ping Tsui
  • Polynucleotide encoding human sodium dependent phosphate transporter (IPT-1)
    Patent number: 6319688
    Abstract: IPT-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IPT-1 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, end stage renal disease, uremic bone disease, and cancer, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: November 20, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: John Feild
  • ASP2
    Patent number: 6319689
    Abstract: ASP2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ASP2 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, cancer, and prohormone processing, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: November 20, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: David J Powell, Conrad G Chapman, Kay Murphy, Trudi S Smith
  • HKABY60 kinase family polypeptides
    Patent number: 6316239
    Abstract: HKABY60 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HKABY60 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammatory disorders, immune disorders and viral diseases, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: November 13, 2001
    Assignee: SmithKline Beecham plc
    Inventor: David Michalovich
  • Compounds
    Patent number: 6316219
    Abstract: ANT5 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ANT5 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: November 13, 2001
    Assignee: SmithKline Beecham Laboratories Pharmaceutiques
    Inventors: Stephane Clement Krief, Michel Louis Souchet, Antoine Michel Alain Bril
  • Tumor necrosis factor related receptor, TR6
    Patent number: 6313269
    Abstract: TR6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR6 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer, atheroschlerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: November 6, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Keith C. Deen, Peter R. Young, Lisa A. Marshall, Amy K. Roshak, Kong B. Tan, Alemseged Truneh
  • Human MAD proteins and uses thereof
    Patent number: 6309856
    Abstract: Human MADr3 or MADr4 polypeptides and DNA (RNA) encoding such MADr3 or MADr4 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such MADr3 or MADr4, or compounds which inhibit or stimulate MADr3 or MADr4 for stimulating wound healing, and treating cancers, among others, are also disclosed. Agonist and antagonists of these MAD proteins and methods of their use are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the MADr3 or MADr4 and for detecting altered levels of the polypeptide in a host.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: October 30, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicholas J. Laping
  • EPO primary response gene, EPRG3Spt
    Patent number: 6306604
    Abstract: EPRG3Spt polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EPRG3Spt polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: October 23, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan B Dillon, Kenneth A Lord
  • Method of identifying agonists and antagonists for tumor necrosis related receptor TR1
    Patent number: 6297022
    Abstract: The present invention relates to tumor necrosis factor receptor (TNF-R) related polypeptide and its ligand, hereinafter referred to as TR1 and TL3. The invention relates to methods to identify agonists and antagonists of TR1 and TL3.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter C. McDonnell, Peter R Young, Jun Zou
  • YAK-1 related serine/threonine protein kinase-HTLAR33
    Patent number: 6297036
    Abstract: HTLAR33 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also, disclosed are methods for utilizing HTLAR33 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Bergsma, Usman Shabon
  • Human Wnt-7a polynucleotides
    Patent number: 6297030
    Abstract: Wnt-7a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-7a polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Michael Robert Barnes, Tania Tamson Testa
  • EXT2 gene
    Patent number: 6287802
    Abstract: EXT2 polypeptides and DNA (RNA) encoding such enzyme and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such EXT2 in the development of treatments for to hereditary multiple exotoses and cancers, such as chondrosarcoma, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: September 11, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Han Xiang Deng, Chao Hong Fan, Jiahui Xia