Patents Represented by Attorney, Agent or Law Firm William T. King
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Patent number: 6447766Abstract: A method of mobilizing hematopoietic stem cells from the bone marrow to the peripheral circulation is provided by administering to an animal an effective amount of mature, modified or multimeric forms of KC, gro&bgr;, gro&agr;, or gro&ggr;.Type: GrantFiled: December 20, 1999Date of Patent: September 10, 2002Assignee: SmithKline Beecham CorporationInventors: Louis Martin Pelus, Andrew Garrison King, Yanqiu Qian
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Patent number: 6433156Abstract: Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16.Type: GrantFiled: December 22, 1998Date of Patent: August 13, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Robert S. Ames, John A. Feild, Tania Testa
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Patent number: 6432678Abstract: Macaca cynomolgus IL18 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize Macaca cynomolgus IL18. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: cancer and auto-immune diseases.Type: GrantFiled: June 20, 2000Date of Patent: August 13, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.Inventors: Alexander H. Taylor, Han N. Trinh
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Patent number: 6432670Abstract: Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.Type: GrantFiled: April 15, 1999Date of Patent: August 13, 2002Assignee: SmithKline Beecham CorporationInventors: David John Payne, Peter Henry Milner, Stewart Campbell Pearson, John Timothy Lonsdale
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Patent number: 6423508Abstract: Human EDG-1c polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Human EDG-1c is identified as a selective receptor for sphingosine-1-phosphate (“S-1-P”) and for di-hydro S-1-P. Also diclsosed are methods for discovering agonists and antagonists of the interaction between S-1-P and di-hydro S-1-P and their cellular receptor, human EDG-1c, which may have utility in the treatment of several human diseases and disorders.Type: GrantFiled: March 4, 1999Date of Patent: July 23, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC, SB Laboratories PharmaceutiquesInventors: Derk J. Bergsma, Winnie Chan, Nassirah Khandoudi, Phillipe Robert
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Patent number: 6420424Abstract: Phenylalanine sulfonamide derivatives and their use as CCR-3 receptor antagonist.Type: GrantFiled: October 27, 2000Date of Patent: July 16, 2002Assignee: SmithKline Beecham CorporationInventors: Dashyant Dhanak, Katherine L. Widdowson, John R. White
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Patent number: 6417215Abstract: Novel calcilytic compounds are provided.Type: GrantFiled: July 26, 2001Date of Patent: July 9, 2002Assignee: SmithKline Beecham CorporationInventor: Amparo Maria Lago
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Patent number: 6413510Abstract: The invention relates to the method of preventing and treating sepsis using chemokines selected from mature or modified KC [SEQ ID NO: 1], gro&agr;[SEQ ID NO:2], gro&bgr;[SEQ ID NO: 3] or gro&ggr;[SEQ ID NO: 4] or multimers thereof, alone or in conjunction with an anti-infective agent. This invention also relates to a new gro&bgr; dimer chemokine.Type: GrantFiled: February 25, 2000Date of Patent: July 2, 2002Assignee: SmithKline Beecham CorporationInventors: Peter Lawrence DeMarsh, Kyung Oh Johanson
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Patent number: 6410555Abstract: Compounds of formula (I) and pharmaceutically acceptable salts and solvates: where R1 is hydrogen, C1-6alkyl (optionally substituted by hydroxy or C1-4alkoxy), phenyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl; R2 is hydrogen or, up to three substituents selected from halogen, NO2, CN, N3, CF3O—, CF3S—, CF3SO2—, CF3CO—, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkyl, C1-6alkylCO—, C3-6cycloalkylO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4alkylO—, C3-6cycloalkyl-C1-4alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS—, C1-6alkylSO2—, (C1-4alkyl)2NSO2—, (C1-4alkyl)NHSO2—, (C1-4alkyl)2NCO—, (C1-4alkyl)NHCO— or CONH2; or —NR5R6 where R5 is hydrogen or C1-4alkyl, and R6 is hydrogen, C1-4alkyl, formyl, —CO2C1-4alkyl or —COC1-4alkyl; or two R2 groups together form a carbocyclic ring that is saturated or unsaturated, optionally inteType: GrantFiled: February 16, 2001Date of Patent: June 25, 2002Assignee: SmithKline Beecham p.l.c.Inventors: John David Harling, Frank Peter Harrington, Mervyn Thompson
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Patent number: 6410286Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.Type: GrantFiled: February 4, 1998Date of Patent: June 25, 2002Assignee: SmithKline Beecham p.l.c..Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
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Patent number: 6410285Abstract: The invention provides alaS polypeptides and DNA (RNA) encoding alaS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing alaS polypeptides to screen for antibacterial compounds.Type: GrantFiled: January 14, 1998Date of Patent: June 25, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventor: Elizabeth Jane Lawlor
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Patent number: 6410688Abstract: The invention provides Def1 polypeptides and DNA (RNA) encoding Def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Def1 polypeptides to screen for antibacterial compounds.Type: GrantFiled: August 13, 1999Date of Patent: June 25, 2002Assignee: SmithKline Beecham CorporationInventors: Michael Arthur Lonetto, Richard Lloyd Warren, Daniel Robert Sylvester
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Patent number: 6403792Abstract: The present invention is to novel sulfonyl isatin compounds of Formula (I), their pharmaceutical compositions, and the novel inhibition of caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.Type: GrantFiled: December 9, 1999Date of Patent: June 11, 2002Assignee: SmithKline Beecham CorporationInventors: Dennis Lee, Scott Allen Long
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Patent number: 6403334Abstract: The invention provides gidB polypeptides and DNA (RNA) encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.Type: GrantFiled: December 16, 1998Date of Patent: June 11, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.Inventor: Howard Kallender
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Patent number: 6399343Abstract: The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.Type: GrantFiled: May 19, 2000Date of Patent: June 4, 2002Assignee: SmithKline Beecham CorporationInventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie
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Patent number: 6399573Abstract: IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia, allergy, parasite infection, allergic rhinitis, allergic asthma, atopic dermatitis, allergic inflammatory diseases, and delayed hypersensitivity, among others, and diagnostic assays for such conditions.Type: GrantFiled: January 28, 2000Date of Patent: June 4, 2002Assignee: SmithKline Beecham CorporationInventor: Peter Ronald Young
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Patent number: 6399053Abstract: The present invention provides a method for the treatment of bacterial, fungal, and viral infections by administering a truncated Gro&bgr;.Type: GrantFiled: December 20, 1999Date of Patent: June 4, 2002Assignee: SmithKline Beecham CorporationInventors: Louis Martin Pelus, Pradip Kumar Bhatnagar, Andrew Garrison King, Joanna Maria Balcarek
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Patent number: 6395919Abstract: Novel calcilytic compounds, pharmaceuticals compositions cotaining said compounds and their use as calcium receptor antagonists.Type: GrantFiled: October 5, 2000Date of Patent: May 28, 2002Assignees: SmithKline Beecham Corporation, NPS PharmaceuticalsInventors: Pradip Kumar Bhatnagar, Joelle Lorraine Burgess, James Francis Callahan, Raul Rolando Calvo, Eric G. Del Mar, Maria Amparo Lago, Thomas The Nguyen
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Patent number: 6395759Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, where G is a methylene or ethylene linkage; R1 is hydrogen, C1-6alkylO—; R2 is hydrogen, halogen, CN, N3, trifluoromethyldiazirinyl, CF3, CF3O—, CF3S—, CF3CO—, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO—, C1-6alkylCO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4-alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl and substituted benzoyl, phenyl-C1-4alkyl-, C1-6alkylSO2—, (C1-4alkyl)2NSO2— or (C1-4alkyl)NHSO2—; R3 is hydrogen, halogen, CN, N3, trifluoromethyldiazirinyl, C1-6alkylO—, C1-6alkylS—, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl, CF3CO—, C1-6alkylCO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, or —NR5R6 where R5 is hydrogen or C1-4alkyl; and R6 is hydrogen, C1-4alkyl, —CHO, —CO2C1-4alkyl or —COC1-4alkType: GrantFiled: June 1, 1999Date of Patent: May 28, 2002Assignee: SmithKline Beecham p.l.c.Inventors: Mervyn Thompson, Antonio Kuok Keong Vong, Robert William Ward
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Patent number: 6391894Abstract: A compound according to Formula (I), hereinbelow: wherein A represents a covalent bond, or a 1,2, 1,3 or 1,4-disubstituted aryl amine ring selected from the group consisting of: wherein R is independently selected from the group consisting of H, OMe, Cl, Br, F, NO2, and CN; n is an integer from 1 to 4; each X is independently selected from the group consisting of H, Br, CH3, NO2, CN, and NR1R2; each Ar is independently optionally substituted phenyl or an optionally substituted 5 or 6 membered heterocyclic ring comprising one or more heteroatoms selected from N, O and S; and R1 and R2 are, independently, hydrogen or C1-4 alkyl, branched or cyclic, optionally containing O or N.Type: GrantFiled: July 19, 2001Date of Patent: May 21, 2002Assignee: SmithKline Beecham CorporationInventor: Maria A. Lago