Patents Represented by Attorney William T. Teoli

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  • Process for the preparation of ste specific 1'-spiro-nucleosides
    Patent number: 5714599
    Abstract: The invention relates to a novel process for stereocontrolled preparation of 1',1'-disubstituted and 1'-spiro-nucleosides of the formula I ##STR1## in which the substituents A, R.sub.8 and R.sub.9 are as defined in claim 1, and to novel intermediates and their use in this process and to processes for the preparation of the novel intermediates. The process is illustrated by the example of biologically active (+)-hydantocidin.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: February 3, 1998
    Assignee: Novartis Corporation
    Inventor: Philippe Chemla
  • Process for producing nitrones
    Patent number: 4709107
    Abstract: A method for preparing nitrones from mixtures of arylhydroxylamines and alkylhydroxylamines containing zinc oxide solids is provided which does not require filtration of the mixture prior to reaction. This is accomplished by introducing a dilute acid solution to the mixture so as to solubilize the zinc oxide powder. The hydroxylamines within solution may be reacted with an aldehyde to produce a nitrone where the dilute acid dissolves the zinc oxide.
    Type: Grant
    Filed: October 11, 1985
    Date of Patent: November 24, 1987
    Assignee: General Electric Company
    Inventors: Paul R. West, Gary C. Davis