Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

Abstract: The multiple interventionless actuated downhole valve includes a valve movable between an open and a closed position to control communication between an annular region surrounding the valve and an internal bore and more specifically controlling communication between above and below the valve, and at least two remotely operated interventionless actuators in operational connection with the valve, wherein each of the interventionless actuators may be operated independently by absolute tubing pressure, absolute annulus pressure, differential pressure from the tubing to the annulus, differential pressure between the annulus and the tubing, tubing or annulus multiple pressure cycles, pressure pulses, acoustic telemetry, electromagnetic telemetry or other types of wireless telemetry to change the position of the valve and allowing the valve to be continually operated by mechanical apparatus.