Abstract: High-yielding hybridoma cell lines which secrete monoclonal antibodies capable of binding to tumor cells of one or more types, but not normal cells can be obtained more readily by fusing myeloma cells with antibody-forming cells isolated from an animal immunized with tumor antigens, which has previously been made immunological tolerant to normal cell antigens, comprising the total antigens, or at least a proportion of the total antigens, of the normal cells corresponding to the tumor cells chosen as the source of immunizing antigens.

Abstract: An apparatus for the recordation of images indicating the location of dental restorations in the mouth of an individual comprises support and positioning means for the person whose dental features are to be recorded, a first source of ultraviolet light located and arranged to illuminate the mouth area of the patient, a second source of visible light located and arranged to illuminate at least the face area of the patient, and a camera located and positioned to take a photograph of at least the mouth area while at least the face area is illuminated by the light sources. The intensity of the light sources may be adjustable to provide an accurate rendering of flesh tones while accentuating the restorations.

Abstract: An archery bow lock mechanism allows a compound bow to be locked in the fully drawn position and released by the archer upon the application of a small amount of additional draw tension. The device utilizes a pair of pawl and ratchet members which approach each other and engage when the bow is drawn. Upon release of the drawstring the cam and ratchet members, which may be in the form of a ball and triangular ratchet, respectively, located on the bow cables, remain engaged, the ball being maintained in contact with a concave face of the ratchet by drawstring tension. Additional tension on the bow string disengages the pawl and ratchet, allowing the bow to be fired. Alternative positions for the ratchet and pawl members are available.

Abstract: An apparatus for assisting in the positioning of a dental X-ray generating unit for the creation of an X-ray image of an internal target portion of the mouth separated from the X-ray generating unit by a soft-tissue facial portion is composed of a substantially X-ray-transparent body adapted to be mounted in the path of the X-rays between the X-ray generating unti and the film element and an illumination source mounted to the body. The body has an outwardly-directed face positioned essentially perpendicular to the X-ray path and facing the soft-tissue facial portion between the X-ray source and target. The illumination source is positioned to direct at least one beam of light perpendicular to and outwardly from the body face towards the facial feature along the path of the X-rays generated by the generating unit to produce at least one light spot on the facial feature to serve as an orientation means for said X-ray unit.

Abstract: A collapsible play structure, such as a doll house, is formed with a base unit having storage means, such as drawers, located therein. A pair of opposed parallel and upright side wall panels, are pivotly mounted to the base, and a plurality or horizontal panels are pivotly mounted to and between the side walls to form the floors and ceilings of the unit. A front wall panel extends upwardly between the side walls and is pivotly attached to the front edge of one of the horizontal panels. Lock means are provided on the horizontal panels and on the front wall panel to removably join the horizontal and front wall panels together to permit the structure to be retained in the upright and upstanding position.

Abstract: Mitomycin derivatives having potent anti-tumor activity having the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 represents carbamoyloxymethyl and the other represents hydrogen or R.sub.1 and R.sub.2 are bonded together to form methylene;X is hydrogen or halogen;Y is hydrogen or methyl;Z is hydrogen, methyl or acyl; andn is an integer of 2 or 3.

Abstract: An improved light socket for use with light bulbs of conventional design and threaded base, has a frame and a cup adapted to accept the light bulb base mounted for longitudinal motion within the frame between a first extended position and a second retracted position. Electrical contacts are provided for establishing electrical continuity with the bulb, the contacts being engaged with the bulb when the cup is in the second, retracted position and disengaged from the bulb when the cup is in the first, extended position. An engagement finger engages the bulb thread when the cup is in the retracted position to retain the bulb in the cup, and releases the bulb when the cup returns to the extended position.

Abstract: A process for producing monoclonal antibodies specific to carcinoembryonic antigen (CEA), comprising immunizing a mammal with a first CEA to produce cells capable of producing antibodies, collecting the cells from the mammal, fusing the collected cells with the cells of a line of myeloma of another mammal, selecting the thus-obtained hybridoma cells on the basis of their capacity to produce antibodies reactive with said first CEA, subjecting the thus-selected hybridoma cells to cloning, selecting the thus-obtained monoclones on the basis of the reactivities of monoclonal antibodies produced by them with at least one antigen selected from CEAs other than said first CEA and CEA-related antigens of normal adult human origin, culturing the thus-obtained monoclones and recovering the desired monoclonal antibodies from the spent culture. The selection may preferably be effected by radioimmunoassay using a marker antigen labelled with a radioactive substance.

Abstract: A biologically active substance comprising a kind of glycolipid having an elemental analysis (%) of H: 5.20-5.40, C: 42.55-44.17 and N: 3.94-4.08 and a molecular weight of about 30,000-10.sup.6 is obtained by extracting the tissue of a plant of maize (Zea mays Linne) or a variant thereof by extracting the tissue with water and recovering the desired active substance from the resultant extract. This substance is capable of inhibiting the formation of IgE antibodies and promoting the formation of IgG and IgM antibodies, and moreover exhibits various biological activities such as interferon-inducing activity, polyclonal B lymphocite activating activity, mitrogenic activity, adjuvant activity and anti-tumour activity. Thus, this substance is expected to be useful for preventing and treating, for example, aesthema, rhintitis, B-type hepatitis, AIDS and other allergic diseases and immunological insufficiency.

Abstract: The invention relates to a process and composition for enhancing the flavor and improving the texture of animal flesh, such as tuna fish in a can, by adding flour, such as rice flour, which has been hydrolyzed with a proteolytic enzyme, to the animal flesh.

Abstract: Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.

Abstract: A mount arrangement for a photographic camera which is capable of automatic diaphragm control and automatic focusing includes electrical contacts for transmission of electrical signals between a camera body and an interchangeable lens unit, and mechanical transmission members for the automatic diaphragm control and the automatic focusing and positioning member and recess on and at inner periphery of mount members of the camera body and the lens unit so as not to interfere with each other during the start and the course of the mounting of the lens unit onto the camera body through a bayonet mount device.

Abstract: A combination arrow sight and support device is adapted to be mounted to an archery bow. A horizontal bar projects outwardly from the bow across the plane defined by drawstring action and in front of the drawn position of the drawstring. An arrow support is mounted to the bar and depends therefrom in the plane of drawstring action. A peep-sight, mounted for adjustable travel along the bar, projects upwardly therefrom. A mounting plate, secured to the bow in the area of the bow's hand-grip portion thereof pivotally supports a bar-support arm about a horizontal axis. The bar support arm is also pivotally mounted to the horizontal bar to allow adjustment of the device in the vertical sense with respect to the bow.

Abstract: A pulmonary muscle trainer consisting of a tubular body having a poppet valve dividing the body into two sections. The poppet is adjustably biased into the closed position, whereby inspiration of a given intensity will be sufficient to overcome the bias and allow air flow through the unit. The poppet is supplied with a one-way valve element to permit the user to create an unrestricted expiration air flow to allow a breathing rhythm to be established. In a preferred embodiment bias is maintained on the poppet by a spring whose compression is adjustable by means of a collar manually positionable within the body of the unit. By the use of the poppet a constant threshold pressure load may be applied.

Abstract: A baking soda box holder for use in confined spaces where odors linger, such as refrigerators or freezers. The holder is a rectangular cube and configuration with a solid bottom wall and at least one solid vertical wall. The remaining walls are defined by frames with open central areas. One of the vertical frames does not have bottom and top skirts to facilitate ingress and egress of the baking soda box. Two-sided adhesive tabs secure the unit in position, either to a wall via the solid vertical wall or a shelf via the solid bottom wall. Calendar strips may be secured to one of the exposed box walls to indicate when to replace the box.

Abstract: A miniaturized delay element was developed for use in medium-and large caliber weapon systems and is realized in a metallic cartridge made of a copper-free light metal. By including a metallic combustible, an oxidant consisting of a halogen-containing high polymer, and metallocenes as sensitizers, an extremely compact and reliable delay element can be produced. By including a detonating charge consisting of an initiating explosive and a metallocene as sensitizer, the delay element can be designed for initiation without darting flame, for striker pins, needles, etc.Due to its properties, the pyrotechnical delay element is particularly well suited for use in highly delayed charges and/or for daughter projectiles and/or for self-destruction of munitions. The delay times achieved can be experimentally and reproducibly determined between 1 and about 30 sec.

Abstract: A clamp formed of a unitary piece of resilient material has a pair of opposed arms pivoted about an integral hinge member located between jaw and finger-grip portions of the arms. An integral biasing element joins the arms at the ends of the finger-grip portion, and is supported such that flex of the biasing element occurs at its central portion, displaced from the arms. The arms may be formed with an internal spine supporting an exterior wall defining the surfaces of the arms.