Patents Represented by Attorney, Agent or Law Firm Woodcock Washburn Kurt Mackiewicz & Norris LLP
  • Imaging of colorectal cancer using ST receptor binding compounds
    Patent number: 6268159
    Abstract: Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent, and a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from metastasized colorectal cancer comprising the steps of administering to said individual a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent, and a therapeutically effective amount of a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radiostable active moiety are disclosed.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: July 31, 2001
    Assignee: Thomas Jefferson University
    Inventor: Scott A. Waldman
  • Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
    Patent number: 6242616
    Abstract: Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: June 5, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Amos B. Smith, III, Thomas J. Beauchamp, Matthew J. LaMarche, Hirokazu Arimoto
  • Methods of synthesis and use
    Patent number: 6235886
    Abstract: Oligonucleotide and nucleotide amine analogs and methods of preparing and using these compounds are provided by the present invention.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: May 22, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, P. Dan Cook
  • Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
    Patent number: 6153599
    Abstract: Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: November 28, 2000
    Assignees: ISIS Pharmaceuticals, Inc., Novartis AG
    Inventors: Nicholas M. Dean, Pierre Martin, Karl-Heinz Altmann
  • Meta-benzylic and alpha-amido compositions and methods for preparing same
    Patent number: 5922872
    Abstract: Compositions comprising meta-benzylic compounds are prepared. The compositions are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compositions of the present invention are useful as research reagents.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: July 13, 1999
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew M. Kawasaki