Abstract: Improved methods for delivering to a patient in need of the drug, while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug are disclosed. The methods are of the type in which prescriptions for the drug are filled only after a computer readable storage medium has been consulted to assure that the prescriber, pharmacy and patient have been properly registered in the medium before the patient is approved to receive the drug. Embodiments are provided wherein the patients are assigned to risk groups based upon the risk that taking the drug will lead to the side effect, and certain additional information, such as periodic surveys and diagnostic tests probative of the ongoing risk of the side effect developing are obtained before prescriptions for the drug are approved.

Abstract: A stiffener assembly for mechanically supporting the main body of an electrical connector to a circuit substrate, such as a daughterboard Printed Circuit Board (PCB). The PCB stiffener assembly is utilized to minimize bowing in the PC Board. The stiffener assembly includes a two-piece or split body having a top clamp and a bottom channel. A latch formed on the top clamp fits over and connectively engages a retention structure disposed on a rear surface of the connector housing. A bottom portion of the top clamp is disposed within the bottom channel. The bottom channel rests on the PCB and the legs of the bottom channel extend upward form the surface of the PCB. One leg of the bottom channel rest against the rear panel and fits under the retention structure. Fasteners pass through the PCB and the bottom channel and engage the top clamp thereby retaining the connector on the PCB.

Abstract: Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.

Abstract: An internal calibration method, used to calibrate a receiver system used in a wireless location system, comprises injecting a signal into the receiver system and utilizing the signal to obtain an estimate of the manner in which the transfer function of the receiver system varies across the bandwidth of the receiver system. This estimate is used to mitigate the effects of the variation of the transfer function on time measurements made by the receiver system. Such time measurements are used to locate mobile transmitters.

Abstract: A computer recovery system provided on a removable high capacity disk. In the event that a user encounters an abnormal operating condition, the user inserts the removable high capacity disk into the computer and restarts the computer. The computer boots either directly from the removable high capacity disk or from a floppy disk which transfers control to the removable high capacity disk. The removable high capacity disk includes all of the files necessary to load the computer operating system and launch the graphical user interface of the operating system such that the user is provided with a familiar operating environment. The removable high capacity disk also includes a suite of software recovery software which attempt to ascertain and correct the cause of the abnormal operating condition to return the computer system to a normal operating condition.

Abstract: The present invention provides monocyclic, bicyclic and oligomeric amine compounds with at least two sites of diversity. These compounds are formed from monocyclic scaffolds which can be cyclized to form bicyclic amine scaffolds. These can then be reacted with building blocks to form the amine compounds of the invention. This invention further provides libraries or monocyclic, bicyclic and oligomeric amine compounds. Also provided are methods for preparing monocyclic, bicyclic and oligomeric amine compounds and libraries thereof. The present invention also provides pharmaceutical compositions of the monocyclic, bicyclic and oligomeric amine compounds.

Abstract: A computer system comprises a plurality of processing modules that can be configured into different partitions within the computer system, and a main memory. Each partition operates under the control of a separate operating system. At least one shared memory window is defined within the main memory to which multiple partitions have shared access, and each partition may also be assigned an exclusive memory window. Program code executing on different partitions enables those partitions to communicate with each other through the shared memory window. Means are also provided for mapping the physical address space of the processors in each partition to the respective exclusive memory windows assigned to each partition, so that the exclusive memory windows assigned to each partition appear to the respective operating systems executing on those partitions as if they all start at the same base address.

Abstract: High-quality composite printing elements are prepared without the need for precise registration of constituent photocurable elements by disposing at least one photocurable element, and preferably a plurality of photocurable elements, upon a surface of a printing element in approximate register and then transferring a computer-generated negative onto a surface of the elements.

Abstract: A hold-down is provided for securing an electrical connector to a printed circuit board. The hold-down is mounted to the housing and/or arms of the electrical connector. The hold-down comprises a base; a first portion formed at one end of the base, with a first terminal extending from the other end of the first portion and substantially parallel to the base; and a second portion formed at the other end of the base, with a second terminal extending from the other end of the second portion and substantially parallel to the base. The hold-down pivots or is free-floating, and therefore, provides coplanarity among the terminals in the electrical connector and the hold-down.

Abstract: A rapidly dispersible powder having use as a laxative and fiber supplement, comprising psyllium particles coated with gum arabic. The present invention also includes a method for making the powder that includes providing an effective quantity of gum arabic to a fluidized bed having the psyllium particles to make the rapidly dispersible powder. The present invention further includes a method for making a constipation treatment and a treatment for fiber supplementation.

Abstract: The present invention provides a method and system that creates a hole with an embossed base in a planar sheet. The system comprises an embossing punch that forms a raised area in the planar sheet, a hole punch coupled to the embossing punch that forms a hole in the planar sheet, and a surface for holding the planar sheet. The surface has an aperture that permits the hole punch and the embossing punch to pass through the surface and contact the planar sheet.

Abstract: A three-phase motor having three Hall-effect devices for production of as many rotor position signals for use in excitation control of its windings, the signals being indicative of the angular position of the motor rotor with respect to the stator and having phase differences of 120 degrees. A motor speed control system is disclosed which utilizes the rotor position signals for detection of the actual running speed of the motor. Included are differentiating circuits connected one to each Hall-effect device for producing outputs in prescribed phase relationship with the rotor position signals. Connected to the differentiating circuits, switching transistors are controlled by binary switch control signals derived from the rotor position signals, passing the positive half-waves, or approximately positive half-waves, of the differentiating circuit outputs. The thus-obtained half-waves are then added together into a motor speed signal representative of the actual running speed of the motor.

Abstract: High oleic acid triglyceride compositions that comprise fatty acid components of at least 75% oleic acid, less than 10% diunsaturated fatty acid component; less than 3% triunsaturated fatty acid component; and less than 8% saturated fatty acid component; and having the properties of a dielectric strength of at least 35 KV/100 mil gap, a dissipation factor of less than 0.05% at 25° C., acidity of less than 0.03 mg KOH/g, electrical conductivity of less than 1 pS/m at 25° C., a flash point of at least 250° C. and a pour point of at least —15° C. are disclosed. Electrical insulation fluids comprising the triglyceride composition are disclosed. Electrical insulation fluids that comprise the triglyceride composition and a combination of additives are disclosed. Electrical apparatuses comprising the electrical insulation fluids and the use of electrical insulation fluids to provide insulation in electrical apparatuses are disclosed.

Abstract: High-quality composite printing elements are prepared without the need for precise registration of constituent photocurable elements by disposing at least one photocurable element, and preferably a plurality of photocurable elements, upon a surface of a substantially planar carrier sheet in approximate register and then transferring a computer-generated negative onto a surface of the elements.

Abstract: A method of inducing resistance to tumor growth comprising placing tumor cells in culture in vitro supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a mammal for a therapeutically effective time, thereby inducing resistance to tumor growth. The pro-apoptotic agents include nucleic acid molecules, proteins or peptides, non-proteins or non-polynucleotide compounds, and a physical conditions.

Abstract: A heat generator comprises a partitioning wall 34 in opposed relation to a rotor in a heat generating area, in which the partitioning wall is formed with a supply groove 38 for introducing the viscous fluid to the outer peripheral area of the heat generating area from a storage area, and a recovery groove 39 for leading out the viscous fluid to the storage area from the outer peripheral area of the heat generating area. The shape, position and the mounting angle of the supply groove 38 and the recovery groove 39 are designed to set the outflow ratio &agr; to not more than 0.92. The outflow ratio &agr; is defined as the ratio (&agr;=Qout1/Qin) of the amount Qout1 of the viscous fluid flowing out from the heat generating area due to the forcible transfer function of the recovery groove 39 to the total amount Qin of the viscous fluid flowing from the storage area into the heat generating area.

Abstract: The apparatus of the present invention increases the operating envelope for large format thermal ink jet printing via a directed fluid flow from specially-designed orifices which promote fluid flow on a printed surface adjacent a printing zone in a large format ink jet printer where in addition to the optimized fluid flow one or more heating elements are inserted directly into the fluid flow to thereby promote drying of said printed surface. In one embodiment, a single dual-duct plennum spans the width of a roll-fed large format ink jet print engine and a first duct distributes heated air downward (in the direction of media web movement) and a second duct evacuates a printing space so that any potentially harmful ink vapors or other air-borne contaminant is appropriately fluidly coupled to either a remote exhaust vent or vapor capture vessel.

Abstract: This invention relates to &agr;-ketoamide inhibitors of multicatalytic protease (MCP), to compositions including such inhibitors, and to methods for the use of MCP inhibitors. The MCP inhibitors of the present invention are useful, for example, to retard loss of muscle mass incident to various physiological states.