Patents Assigned to 1ST Biotherapeutics, Inc.
  • Substituted indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors
    Patent number: 11834467
    Abstract: The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salts thereof, a composition comprising the compound, methods of using the compound for the treatment of various disorders associated with HPK1, and methods of preparing these compounds.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: December 5, 2023
    Assignee: 1ST Biotherapeutics, Inc.
    Inventors: Jinhwa Lee, Suyeon Jo, Keonseung Lim, A Yeong Park, Gadhe Changdev Gorakshnath, Hwajung Nam, Yeonguk Jeon, Yejin Hwang, Jae Eun Kim, Misoon Kim, Seung Mook Lim
  • Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
    Patent number: 11802126
    Abstract: The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method to treat or prevent neurodegenerative diseases using the compound.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: October 31, 2023
    Assignee: 1ST Biotherapeutics, Inc.
    Inventors: Jinhwa Lee, Suyeon Jo, Keonseung Lim, A Yeong Park, Jae Eun Kim, Misoon Kim, Seung Mook Lim
  • 2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds
    Patent number: 11744824
    Abstract: The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method for treating or preventing an inflammatory and autoimmune diseases, especially neuroinflammation diseases using the compound.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: September 5, 2023
    Assignee: 1ST Biotherapeutics, Inc.
    Inventors: Jinhwa Lee, Suyeon Jo, Keonseung Lim, A Yeong Park, Gadhe Changdev Gorakshnath, Hwajung Nam, Yeonguk Jeon, Yejin Hwang, Jae Eun Kim, Misoon Kim, Inyoung Yang
  • Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same
    Patent number: 11649255
    Abstract: The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salts thereof, a composition comprising the compound, methods of using the compound for the treatment of various disorders associated with HPK1, and methods of preparing these compounds.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: May 16, 2023
    Assignee: 1ST Biotherapeutics, Inc.
    Inventors: Jinhwa Lee, Suyeon Jo, Keonseung Lim, A Yeong Park, Gadhe Changdev Gorakshnath, Hwajung Nam, Yeonguk Jeon, Yejin Hwang, Jae Eun Kim, Misoon Kim, Seung Mook Lim
  • Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
    Patent number: 11098044
    Abstract: The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method to treat or prevent neurodegenerative diseases using the compound.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: August 24, 2021
    Assignee: 1ST Biotherapeutics, Inc.
    Inventors: Jinhwa Lee, Suyeon Jo, Keonseung Lim, A Yeong Park, Jae Eun Kim, Misoon Kim, Seung Mook Lim
  • Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
    Patent number: 10968188
    Abstract: The present disclosure provides a compound of general Formula (I) having c-abl kinase inhibitory activity or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound, and a method useful to treat or prevent neurodegenerative diseases using the compound.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: April 6, 2021
    Assignee: 1st Biotherapeutics, Inc.
    Inventors: Jinhwa Lee, Suyeon Jo, A Yeong Park, Gwibin Lee, Jae Eun Kim, Misoon Kim, Gyooseung Jung, Seung Mook Lim, Keonseung Lim, Minwoo Lee, Heekyoung Yang, Hyonam Kim, Hyeongjun Kim, Wanjun Li, Mingzhu Fan
  • Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
    Patent number: 10669246
    Abstract: The present disclosure provides a compound of general Formula (I) having c-abl kinase inhibitory activity or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound, and a method useful to treat or prevent neurodegenerative diseases using the compound.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: June 2, 2020
    Assignee: 1ST Biotherapeutics, Inc.
    Inventors: Jinhwa Lee, Suyeon Jo, Gwibin Lee, Keonseung Lim, A Yeong Park, Wanjun Li, Mingzhu Fan
  • Processes for preparing benzothiazol compounds and methods of using the same for treating neurodegenerative disorders
    Patent number: 10385046
    Abstract: The present disclosure provides a process for preparing (1S,2S)-2-fluoro-N-(6-(4-methylpyridin-3-yl)benzo[d]thiazol-2-yl) cyclopropanecarboxamide or a salt thereof, such as the compound of Formula (I), comprising: reacting Compound 1 as a starting material with Compound 2 in the presence of Pd(dppf)Cl2 and 1,4-dioxane to form Compound 3; reacting Compound 3 with Compound 4 in the presence of HATU and DIPEA to produce Compound 5; and reacting Compound 5 with hydrochloric acid to produced Formula (I).
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: August 20, 2019
    Assignee: 1ST Biotherapeutics, Inc.
    Inventors: Jinhwa Lee, Suyeon Jo