Abstract: Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical compositions thereof and use thereof. The present disclosure provides a nitrogen-containing heterocyclic compound represented by formula I, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of pharmaceutically acceptable salt thereof, a crystal thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compound represented by formula I is expected to treat and/or prevent various PI3K-meditated diseases.
Type:
Application
Filed:
September 11, 2023
Publication date:
May 16, 2024
Applicant:
280 Bio, Inc.
Inventors:
Zusheng XU, Lin XIA, Xiangqian LI, Haoran YANG
Abstract: Disclosed is a nitrogen-containing heterocyclic compound, a method for preparing the same and a use of the same. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof, and the nitrogen-containing heterocyclic compound is expected to treat and/or prevent various RAS-related diseases.
Type:
Application
Filed:
May 23, 2022
Publication date:
December 7, 2023
Applicant:
280 Bio, Inc.
Inventors:
Zusheng XU, Yangtong LOU, Jian SHEN, Tiegang XIE, Qingrui SUN, Li CHEN, Kun ZENG, Xin JIN
Abstract: Disclosed is a five-membered heteroaromatic ring structure containing compound, pharmaceutical compositions thereof and applications thereof. The present disclosure provides a five-membered heteroaromatic ring structure containing compound of formula I, pharmaceutical compositions thereof and applications thereof and the five-membered heteroaromatic ring structure containing compound is expected to treat and/or prevent various PARG-related diseases.
Type:
Application
Filed:
March 6, 2023
Publication date:
September 7, 2023
Applicant:
280 Bio, Inc.
Inventors:
Zusheng XU, Yangtong LOU, Tiegang XIE, Linlin XU, Li CHEN, Yanhang LIU, Qingrui SUN
Abstract: Disclosed is a nitrogen-containing heterocyclic compound, a preparation method therefor and use thereof. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof, and the nitrogen-containing heterocyclic compound is expected to treat and/or prevent various RAS-related diseases.