Abstract: A process is described for the preparation of modified electrodes useful for the measurement of analytes in biological fluids, comprising the deposition of Prussian blue on screen printed electrodes, and the modified electrodes prepared via said process; the enzymatic electrodes and the biosensors comprising said modified electrodes and the method for the determination of analytes in biological fluids which uses said modified electrodes are also described.
Type:
Grant
Filed:
December 13, 2007
Date of Patent:
November 13, 2012
Assignee:
A. Menarini Industrie Farmaceutiche Riunite S.R.L.
Inventors:
Giuseppe Palleschi, Francesco Ricci, Danila Moscone, Alessandro Poscia
Abstract: Portable device for the measurement and control of analytes in biological fluids, provided with biosensor for measurement and control of biological fluids such as glucose and other analytes characterized by the possibility of using electrolytic cells with two, three or more electrodes, with polarization voltage between a few millivolts and 100 millivolts; the possibility of measuring the fluid temperature at the outlet of the electrolytic cell in high resolution mode for diagnostic purposes, hence it can also be used for performing very accurate thermal compensation of the electrochemical measurement; the possibility of performing optimised correction of both the systematic and random errors in the measurement performed; the possibility of calibrating the sensors used more accurately and efficiently and, lastly, the possibility of performing the measurement with much lower polarization voltages at the electrodes than the equipment in the state of the art with consequent benefits in terms of reduced wear of th
Type:
Grant
Filed:
December 6, 2007
Date of Patent:
September 25, 2012
Assignee:
A. Menarini Industrie Farmaceutiche Riunite S.R.L.
Inventors:
Giorgio Dall'Oglio, Francesco Valgimigli
Abstract: The invention relates to a new derivative of aryldimethylpyrazolone of formula (I) which is effective in reducing unsightly cellulite, and compositions containing it.
Abstract: The invention relates to a new derivative of aryldimethylpyrazolone of formula (I) which is effective in reducing unsightly cellulite, and compositions containing it.
Abstract: An apparatus for the continuous measurement of glucose and lactate in interstitial fluids including a glucose measurement cell, an A/D conversion block, a memory block and a bi-directional communication between the interface block and an external calculation unit.
Abstract: Process for the preparation of 2-halomethyl-penems (I) comprising (a) reacting an acetoxy-(protected hydroxyethyl)-2-azetidinone (III) with a 2-halothioacetic acid to form a 3-haloacetylthioazetidinone (V), (b) reacting (V) with oxalyl chloride to give an intermediate (VII), acylated on the beta-lactamic nitrogen, and (c) cyclizing (VII) in the presence of an organic phosphate or phosphonite to produce the corresponding 2-halomethyl-penem (I).
Abstract: The present invention refers to tachykinins antagonists of general formula (I) ##STR1## their preparation and pharmaceutical compositions containing them.
Type:
Grant
Filed:
September 9, 1997
Date of Patent:
December 15, 1998
Assignee:
A Menarini Industrie Farmaceutiche Riunite S.r.l.
Inventors:
Alessandro Sisto, Edoardo Potier, Stefano Manzini, Christopher Fincham, Paolo Lombardi, Federico Arcamone
Abstract: 8-fluoro-anthracyclines of formula (I) have anti-tumor activity. ##STR1## wherein: R is chosen in the group consisting of H, OH, OR.sub.4 wherein R.sub.4 is chosen in the group consisting of CHO, COCH.sub.3, acyl derivative of a carboxylic acid containing up to 6 carbon atoms;R.sub.1 is chosen in the group consisting of: H, OH, OCH.sub.3 ;R.sub.2 is chosen in the group consisting of: H, OH, NH.sub.2R.sub.3 is chosen in the group consisting of: H, OH, NH.sub.2, residue of formula (A) ##STR2## The compounds are characterized by having cis-stereochemistry between the groups 8--F and 9--OH. Their preparation and pharmaceutical compositions containing them are also described.
Type:
Grant
Filed:
April 21, 1997
Date of Patent:
September 29, 1998
Assignees:
Bristol-Myers Squibb, S.p.A., A. Menarini Industrie Farmaceutiche Riunite S.R.L.
Inventors:
Fabio Animati, Federico Arcamone, Giuseppe Giannini, Paolo Lombardi, Edith Monteagudo
Abstract: New 8-fluoroanthracycline derivatives of formula I possessing antitumoral properties are described, together with their preparation and pharmaceutical compositions containing them.
Type:
Grant
Filed:
May 14, 1991
Date of Patent:
September 15, 1998
Assignee:
A. Menarini Industrie Farmaceutiche Riunite S.r.l.
Inventors:
Fabio Animati, Paolo Lombardi, Federico Arcamone
Abstract: The present invention is referred to compounds of general formula (I) and (II), respectively ##STR1## their pharmaceutically acceptable salts, the process for their preparation, and the pharmaceutical compositions containing them.
Type:
Grant
Filed:
March 28, 1996
Date of Patent:
September 1, 1998
Assignees:
A. Menarini Industrie Farmaceutiche Riunite S.r.l., Bristol-Myers Squibb S.p.A.
Inventors:
Fabio Animati, Paolo Lombardi, Frederico Arcamone, Amalia Cipollone
Abstract: A description is given of tachykinin receptor antagonists having general formula (I) ##STR1## their preparation and use in pharmaceutical formulations.
Abstract: The present invention refers to tachykinins antagonists of general formula (I) ##STR1## their preparation and pharmaceutical compositions containing them.
Type:
Grant
Filed:
July 8, 1996
Date of Patent:
December 16, 1997
Assignee:
A. Menarini Industrie Farmaceutiche Riunite S.r.l.
Inventors:
Alessandro Sisto, Edoardo Potier, Stefano Manzini, Christopher Fincham, Paolo Lombardi, Federico Arcamone
Abstract: This invention relates to polyaminopyrrolecarboxyamide derivatives of general formula (I) and their pharmaceutically acceptable salts, in which A represents a chemical bond or an aromatic or heteroaromatic radical, and:if A is a chemical bond, R is hydrogen, alkyl, dialkylaminoalkyl, alkenyl, cycloalkyl, arylalkyl, arylalkenyl, haloalkyl, or an aromatic or heteroaromatic radical;whereas if A is an aromatic or heteroaromatic radical, R is nitro, amino or formylamino;n is 0 or a whole number between 1 and 4;Z is an alkylene or aromatic radical.
Type:
Grant
Filed:
August 6, 1993
Date of Patent:
December 5, 1995
Assignees:
A. Menarini Industrie Farmaceutiche Riunite S.r.l., Bristol-Meyers Squibb S.p.A.
Inventors:
Fabio Animati, Federico Arcamone, Giuseppe Giannini, Paolo Lombardi
Abstract: A synthetic peptide corresponding to the following formula:X--Asp--Y--DTrp--Val--DTrp--Z--K--NH.sub.2where:X=H, Arg, DArg, Lys, DLys, Thr, DThrY=Tyr, Trp, DTrp, Ser, MetZ=Trp, DTrpK=Arg, Phe, DTrp, Tyr, Metand pharmaceutically acceptable salts thereof with organic and inorganic acids as competitive antagonists against neurokinin A (NK-2 receptor).
Type:
Grant
Filed:
May 24, 1990
Date of Patent:
July 7, 1992
Assignee:
A. Menarini Industrie Farmaceutiche Riunite S.r.l.
Inventors:
Paolo Rovero, Vittorio Pestellini, Carlo A. Maggi, Riccardo Patacchini, Paolo Santicioli, Sandro Giuliani, Alberto Meli