Abstract: A PET and Compton imaging method implemented by a device including at least two facing PET modules. The device includes a Compton camera arranged outside a plane containing the PET modules for forming a trihedron with the PET modules and producing a Compton view. The acquisition fields of the PET and Compton views having an overlap area covering the object to be imaged. The device allowing the following steps to be carried out: acquisition of a Compton view; location of a dense area and its contour on the Compton view; Computation of the 2D map of the probability of detection of the presence of a source from the Compton view of the Compton camera; Coincidence detection by the PET cameras and association of a response line (LOR); and Segmentation of LORs crossing the dense area by using the detection probability determined by the Compton view.