Abstract: The present invention is related to a new process for the separation of oil and/or phosphatidylethanolamine from alcohol soluble phosphatidylcholine products containing the same thus producing a highly purified phosphatidylcholine, by chromatography on silicic acid gel in a lower alkanol containing 1 to 4 carbon atoms as solvent and/or eluant.
Abstract: A novel pharmaceutical composition is provided which is suitable for the prevention of inflammation and which comprises a non-steroidal inflammation-preventing compound (e.g. pyrazolones, salicylic acid derivatives, indoles, indanes, and phenylacetic acid and anthranilic acid derivatives) and at least one phospholipid.
Abstract: The present invention is related to new benzisoselenazolones having the general formula I ##STR1## new products having the general formula II ##STR2## used as intermediary products in the production of the compounds of formula I and a method for the treatment of rheumatic diseases using a compound of formula I as active agent.
Type:
Grant
Filed:
July 9, 1981
Date of Patent:
November 29, 1983
Assignee:
A. Nattermann & Cie GmbH
Inventors:
Andre Welter, Leon Christiaens, Ferdinand Wirtz-Peitz
Abstract: The invention relates to the new use of certain benzisothiazoles corresponding to the following general formula: ##STR1## wherein R.sub.1 represents chlorine, fluorine or bromine, and R.sub.2 represents hydrogen, chlorine, fluorine or bromine, in the treatment of phlogistic and/or arteriosclerotic processes.
Type:
Grant
Filed:
October 22, 1981
Date of Patent:
August 9, 1983
Assignee:
A. Nattermann & Cie GmbH
Inventors:
Andre Welter, Hans-Heiner Lautenschlager, Eugen Etschenberg, Sigurd Leyck
Abstract: A novel pharmaceutical composition is provided which is suitable for the prevention of inflammation and which comprises non-steroidal inflammation-preventing compound (e.g. pyrazolones, salicylic acid derivatives, indoles, indanes, and phenylacetic acid and anthranilic acid derivatives) and at least one phospholipid.
Abstract: The present invention refers to new .omega.-(2-oxo-benzazolinyl)-alkanoic acids as well as salts and esters thereof having the general formula I ##STR1## and having antiinflammatory, analgesic and antithrombotic activity.
Type:
Grant
Filed:
November 6, 1981
Date of Patent:
March 22, 1983
Assignee:
A. Nattermann & Cie GmbH
Inventors:
Hans-Heiner Lautenschlager, Hans Betzing, Brigitte Stoll, Manfred Probst
Abstract: A novel pharmaceutical composition is provided which is suitable for the prevention of inflammation and which comprises a neo-steroidal inflammation-preventing compound (e.g. pyrazolones, salicylic acid derivatives, indoles, indanes, and phenylacetic acid and anthranilic acid derivatives) and at least one phospholipid.
Abstract: The present invention is directed to a new rosmarinic acid-phospholipide-complex product containing rosmarinic acid and the phospholipide in a molar ratio of 1:2. The invention is further directed to a process for producing the same and to pharmaceutical preparations containing the same.
Type:
Grant
Filed:
December 11, 1980
Date of Patent:
November 9, 1982
Assignee:
Nattermann & Cie GmbH
Inventors:
Ferdinand Wirtz-Peitz, Manfred Probst, Johannes Winkelmann
Abstract: The present invention is related to a new process for producing rosmarinic acid by extraction of certain plants, and in particular of plants of balmmint (Melissa officinalis).
Abstract: The present invention is related to pharmaceutical preparations containing as active components the known compound 2-phenyl-1.2-benzisoselenazol-3(2H)-one containing pharmaceutical preparations and process for the treatment in particular of rheumatic diseases.
Type:
Grant
Filed:
July 9, 1981
Date of Patent:
October 5, 1982
Assignee:
A. Nattermann & Cie GmbH
Inventors:
Marcel Renson, Eugen Etschenberg, Johannes Winkelmann
Abstract: The present invention refers to N-substituted .omega.-(2-oxo-4-imidazolin-1-yl) alcanoic acids as well as salts and esters thereof having the general formula I ##STR1## The compounds are useful, for example, as antiallergics, antiasthmatics, etc.
Type:
Grant
Filed:
November 6, 1981
Date of Patent:
September 14, 1982
Assignee:
A. Nattermann & Cie GmbH
Inventors:
Hans-Heiner Lautenschlager, Hans Betzing, Brigitte Stoll, Manfred Probst
Abstract: 2-Oxo-1-pyrrolidinylalkylcarboxylic acid amides of formula I ##STR1## in which R represents a hydrogen atom or hydroxy group, R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents a substituted or unsubstituted pyridyl group or a substituted phenyl group, the substitution being by from 1 to 3 substituents, which may be the same or different selected from halogen atoms, trifluoromethyl, nitro and acetyl groups, straight or branched-chain alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms, straight or branched-chain alkylmercapto groups having 1-7 carbon atoms, substituted alkylmercapto groups of the general formula II ##STR2## in which n represents 1 or 2, R.sub.3 is a hydrogen atom or a methyl group and R.sub.4 is a hydroxy group or an amino group of the general formula V ##STR3## in which R.sub.8 represents a hydrogen atom or methyl group and R.sub.9 represents a methyl group or substituted or unsubstituted benzyl group, or R.sub.8 and R.sub.
Type:
Grant
Filed:
June 3, 1980
Date of Patent:
July 27, 1982
Assignee:
A. Nattermann & Cie. GmbH
Inventors:
Hans Betzing, Jurgen Biedermann, Carsten Materne, Volker Neuser
Abstract: A novel pharmaceutical composition is provided which is suitable for the prevention of inflammation and which comprises non-steroidal inflammation-preventing compound (e.g. pyrazolones, salicylic acid derivatives, indoles, indanes, and phenylacetic acid and anthranilic acid derivatives) and at least one phospholipid.
Abstract: .omega.-(2-Oxo-4-imidazolin-1-yl) alkanoic acids and salts and esters thereof of the formula: ##STR1## in which n denotes an integer from 1 to 8, R.sup.1 denotes H, a non-toxic cation or a straight-chain or branched, saturated hydrocarbon group of 1 to 6 carbon atoms, and R.sup.2 denotes an unsubstituted or substituted aromatic radical of formula ##STR2## or naphthyl, the substituents X and Y being identical or different and each representing H, halogen or alkoxy have strong antithrombotic activity and an analgesic effect.
Type:
Grant
Filed:
August 15, 1980
Date of Patent:
May 18, 1982
Assignee:
A. Nattermann & Cie. GmbH
Inventors:
Hans-Heiner Lautenschlager, Hans Betzing, Brigitte Stoll
Abstract: The present invention is directed to a new process for the treatment of inflammatory diseases and disorders in humans by administering a pharmaceutical preparation containing rosmarinic acid.
Type:
Grant
Filed:
December 11, 1980
Date of Patent:
May 11, 1982
Assignee:
Nattermann & Cie GmbH
Inventors:
Meinhard Zenk, Eugen Etschenberg, Erich Graf
Abstract: Solutions of anti-inflammatory acrylacetic and arylpropionic acid derivatives are stabilized by addition of phospholipids. The solutions are suitable for parenteral administration; they are well tolerated and have a long-lasting action.
Type:
Grant
Filed:
April 10, 1980
Date of Patent:
January 5, 1982
Assignee:
A. Nattermann & Cie. GmbH
Inventors:
Miklos Ghyczy, Gotz Ritzmann, Adorjan Erdos, Eugen Etschenberg
Abstract: Stable solutions of anti-inflammatory indoleacetic acid derivatives and indanacetic acid derivatives comprise the said derivative and a phospholipid. Such solutions can be administered by injection and have a long-lasting therapeutic effect.
Type:
Grant
Filed:
April 10, 1980
Date of Patent:
January 5, 1982
Assignee:
A. Nattermann & Cie. GmbH
Inventors:
Miklos Ghyczy, Gotz Ritzmann, Adorjan Erdos, Eugen Etschenberg
Abstract: The invention provides novel .omega.-(5-alkenylthien-2-yl)alkanecarboxylic acids and their functional derivatives having the formula ##STR1## wherein n is an integer from 1 to 9, inclusive; R.sup.1 is H and R.sup.2 is --OH, or R.sup.1 and R.sup.2 together with the wavy lines represent a keto group; and R.sup.3 is H, C.sub.1 -C.sub.6 straight or branched-chain saturated hydrocarbon, or a pharmaceutically acceptable alkali cation. The 3-oxoalkenyl-substituted compounds of formula (I) are prepared by a Wittig-Horner reaction using a 2-oxoheptylphosphonic acid dialkyl ester and an aldehyde of the formula ##STR2## as starting materials, while the 3-hydroxyalkenyl-substituted compounds are obtained by reduction of the corresponding 3-oxoalkenyl compounds. The esters of formula (I) can also be readily converted to the corresponding acids and salts of formula (I).
Type:
Grant
Filed:
November 12, 1980
Date of Patent:
January 5, 1982
Assignee:
A. Nattermann & Cie. GmbH
Inventors:
Hans-Heiner Lautenschlager, Hans Betzing, Johannes Winkelmann, Manfred Probst