Abstract: COVID-19 is treated with antisense oligonucleotides (ASOs) targeting SARS-CoV-2 viral RNAs or human ACE2 RNA.

Abstract: The present disclosure relates to a method for detecting and/or quantitatively assessing cardiac dyssynchrony of a subject based on at least one medical imaging scan showing at least part of the myocardium of the subject’s heart, in particular mechanical cardiac dyssynchrony. The medical imaging scan may provide a plurality of values of a predefined myocardial deformation parameter of said part of the myocardium. In a preferred embodiment the method comprises the steps of 1) determining a myocardial deformation deviation between pairs of myocardial deformation parameter values selected from the myocardium of substantially opposite parts of a cardiac chamber, and 2) calculating the cardiac dyssynchrony of the subject based on said myocardial deformation deviation.

Abstract: The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.

Abstract: A method is provided for determining pulmonary embolism and/or increased risk thereof in a human being, comprising collecting a sample of exhalation air from said human being and determining the presence or absence in said exhaled air of one or more biomarkers associated with pulmonary embolism. Additionally, a kit that comprises the means for detecting at least one biomarker associated with pulmonary embolism or risk thereof is provided.

Abstract: A suction bucket for a seabed foundation for an offshore facility is provided. The suction bucket is arranged for being embedded into a marine sediment. The suction bucket includes a lid and a sidewall. The sidewall is segmented into a first circumferential segment and at least a second circumferential segment. The first circumferential segment is connected with the second circumferential segment. The first circumferential segment and the second circumferential segment are attached to the lid of the suction bucket. Furthermore, the first circumferential segment and the second circumferential segment each contains at least one substantially planar section. Furthermore, a method to manufacture a suction bucket for a seabed foundation for an offshore facility is also provided.

Abstract: Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

Abstract: The present subject matter relates to antenna systems, devices, and methods that are designed to avoid the degradation of the end-fire radiation pattern of the array when a piece of metal is added obstructing the direction of the main beam. A parasitic radiator is positioned in proximity to the blocking structure and configured to couple at least part of the reflected radiation pattern and radiate toward the desired end-fire direction.

Abstract: A method is provided, which comprises providing a dried body fluid card sample, extracting body fluid from said dried body fluid card sample, and detecting gene products associated with extracellular vesicles. An application of the method is also applied for diagnosing and/or prognosing a clinical condition, where gene products associated with a population of extracellular vesicles and gene products associated with the clinical condition are detected.

Abstract: The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.

Abstract: Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

Abstract: A method of determining pancreatic cancer based on specific methylation markers is provided, where the methylation markers are identified in cell-free DNA obtainable from blood samples. Furthermore, treatment of pancreatic cancer is disclosed. Specific primers are also provided for use in determining pancreatic cancer.

Abstract: Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides. As shown herein, the hetero chromatic HSATII satellite repeat is silenced in normal cells, but massively over expressed in epithelial cancers and in cancer cell lines when grown as xenografts or in 3D culture. Induction of HSATII RNA, either in xenografts or using in vitro reconstitution models, suggests the appearance of complementary DNA intermediates.

Abstract: An apparatus for controlling force of a magnetic lead screw actuator includes a magnetic lead screw actuator, an external control module and at least one sensor device integrated within the magnetic lead screw actuator. The magnetic lead screw actuator includes an electric machine, a rotor, and a translator. The rotor includes a rotor magnet assembly forming first helical magnetic threads along the rotor and the translator includes a translator magnet assembly forming second helical magnetic threads along the translator. Rotation of the rotor by the electric machine effects linear translation of the translator by interaction of the first and second helical magnetic threads. The external control module is electrically operatively coupled to an electric machine controller of the magnetic lead screw actuator.