Patents Assigned to Abaxis, Inc.
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Publication number: 20110136155Abstract: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.Type: ApplicationFiled: November 17, 2010Publication date: June 9, 2011Applicant: ABAXIS, INC.Inventors: RAJESH K. MEHRA, KENNETH P. ARON, DENNIS M. BLEILE
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Publication number: 20110124125Abstract: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic ehrlichiosis.Type: ApplicationFiled: November 19, 2010Publication date: May 26, 2011Applicant: Abaxis, Inc.Inventors: Rajesh K. MEHRA, Kenneth P. ARON, Dennis M. BLEILE
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Publication number: 20100233708Abstract: The present invention provides an analyte detection system for detecting a target analyte in a sample. In particular, the invention provides a detection system capable of one-step amplification of the detection signal by incorporating a secondary flow path that can deliver reagents to a reaction zone. Methods of using the detection system to detect analytes in samples, particularly biological samples, and kits comprising the detection system are also disclosed.Type: ApplicationFiled: March 11, 2010Publication date: September 16, 2010Applicant: Abaxis, Inc.Inventors: Rajesh MEHRA, Kenneth P. Aron, Madeline Netto
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Patent number: 7765069Abstract: Methods and systems are provided for detecting the accidental use of short and long samples in the clinical analysis of a sample, specimen, or assay. The systems can include a clinical analyzer for determining one or more values for one or more measurable characteristics of a sample. These values are used in combination with reference data stored in a data module to generate a probability that the sample tested is a short sample, a long sample, or an acceptable sample. This probability and/or the status of the sample as a short sample, a long sample, or an acceptable sample are output to a user.Type: GrantFiled: August 4, 2005Date of Patent: July 27, 2010Assignee: Abaxis, Inc.Inventors: Vladimir E. Ostoich, Kenneth Aron, Dennis M. Bleile
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Publication number: 20100159441Abstract: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.Type: ApplicationFiled: March 18, 2009Publication date: June 24, 2010Applicant: ABAXIS, INC.Inventors: VINCENT CHIANG, RAJESH K. MEHRA
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Publication number: 20100136566Abstract: The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are lateral flow assay devices comprising immobilized metal nanoparticle conjugates as the detection means. Methods of using the devices and kits comprising the devices are also described.Type: ApplicationFiled: December 3, 2009Publication date: June 3, 2010Applicant: ABAXIS, INC.Inventors: Rajesh K. MEHRA, Kenneth P. ARON
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Publication number: 20100120057Abstract: The present invention discloses methods of reducing non-specific interactions of interfering species present in a sample in metallic nanoparticle-based assays, thereby increasing the sensitivity of these assays. In particular, the methods entail neutralizing the chemical reactivity of functional groups present in interfering species by addition of a neutralizing agent, such as an alkylating agent or heavy metal ion. The methods are especially useful in assays for the detection of analytes in biological samples. Reagent kits and assay mixtures for the practice of the described methods are also disclosed.Type: ApplicationFiled: July 9, 2009Publication date: May 13, 2010Applicant: ABAXIS, INC.Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth Aron
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Patent number: 7177767Abstract: Methods and systems are provided for detecting the accidental use of short and long samples in the clinical analysis of a sample, specimen, or assay. The systems can include a clinical analyzer for determining one or more values for one or more measurable characteristics of a sample. These values are used in combination with reference data stored in a data module to generate a probability that the sample tested is a short sample, a long sample, or an acceptable sample. This probability and/or the status of the sample as a short sample, a long sample, or an acceptable sample are output to a user.Type: GrantFiled: October 18, 2002Date of Patent: February 13, 2007Assignee: Abaxis, Inc.Inventors: Vladimir E. Ostoich, Kenneth Aron, Dennis M. Bleile
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Patent number: 6818415Abstract: Chloride ion and sodium ion determination methods, compositions, and assays are provided which are based on the use of sodium ion as an activator for &agr;-amylase. Chloride ion and sodium ion determination are performed by colorimetry, using measurements of &agr;-amylase activity to indirectly measure the desired ion concentrations. One preferred composition for chloride ion determination comprises &agr;-amylase that is substantially calcium free, sodium ion in higher concentration than the &agr;-amylase, and an &agr;-amylase activity detecting substrate. In the methods, &agr;-amylase is deactivated by a calcium-binding compound, thereby preventing calcium from bonding with the &agr;-amylase. Next, chloride ion and sodium ion stoichiometrically bond with deactivated &agr;-amylase, thereby activating the &agr;-amylase.Type: GrantFiled: June 22, 2001Date of Patent: November 16, 2004Assignee: Abaxis, Inc.Inventor: Vincent Chiang
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Patent number: 6752961Abstract: The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors comprise siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.Type: GrantFiled: April 12, 2001Date of Patent: June 22, 2004Assignee: Abaxis, Inc.Inventors: Anne R. Kopf-Sill, Carol T. Schembri
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Publication number: 20030022264Abstract: Chloride ion and sodium ion determination methods, compositions, and assays are provided which are based on the use of sodium ion as an activator for &agr;-amylase. Chloride ion and sodium ion determination are performed by colorimetry, using measurements of &agr;-amylase activity to indirectly measure the desired ion concentrations. One preferred composition for chloride ion determination comprises &agr;-amylase that is substantially calcium free, sodium ion in higher concentration than the &agr;-amylase, and an &agr;-amylase activity detecting substrate. In the methods, &agr;-amylase is deactivated by a calcium-binding compound, thereby preventing calcium from bonding with the &agr;-amylase. Next, chloride ion and sodium ion stoichiometrically bond with deactivated &agr;-amylase, thereby activating the &agr;-amylase.Type: ApplicationFiled: June 22, 2001Publication date: January 30, 2003Applicant: ABAXIS, INC.Inventor: Vincent Chiang
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Patent number: 6251684Abstract: The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers.Type: GrantFiled: April 24, 1998Date of Patent: June 26, 2001Assignee: Abaxis, Inc.Inventors: Steven N. Buhl, Bhaskar Bhayani, Chi-Sou Yu, Thuy N. Tang
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Patent number: 6235531Abstract: The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors include siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.Type: GrantFiled: November 22, 1995Date of Patent: May 22, 2001Assignee: Abaxis, Inc.Inventors: Anne R. Kopf-Sill, Carol T. Schembri
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Patent number: 5998031Abstract: The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers.Type: GrantFiled: October 16, 1997Date of Patent: December 7, 1999Assignee: Abaxis, Inc.Inventors: Steven N. Buhl, Bhaskar Bhayani, Chi-Sou Yu, Thuy N. Tang
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Patent number: 5776563Abstract: The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers.Type: GrantFiled: June 6, 1995Date of Patent: July 7, 1998Assignee: Abaxis, Inc.Inventors: Steven N. Buhl, Bhaskar Bhayani, Chi-Sou Yu, Thuy N. Tang
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Patent number: 5624597Abstract: The present invention provides lyophilized reagent spheres comprising reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. Also provided are diluents which are conveniently used in such analyzers.Type: GrantFiled: May 8, 1995Date of Patent: April 29, 1997Assignee: Abaxis, Inc.Inventors: Steven N. Buhl, Terri Bogart, Tammy Burd, Bhaskar Bhayani, Christian Skieller, Chi-Sou Yu, Thuy N. Tang, Vladimir E. Ostoich, Branko Huc, Carol T. Schembri
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Patent number: 5599411Abstract: A method and a device for modifying the energy-applying surface of an ultrasonic welding horn to join two complex thermoplastic parts by applying a thin film to the surface of the horn is disclosed. The thin film is applied to insure that a proper weld occurs along a complex and intricate pattern of energy directors located between the parts.Type: GrantFiled: December 6, 1994Date of Patent: February 4, 1997Assignee: Abaxis, Inc.Inventor: Carol Schembri
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Patent number: 5591643Abstract: The present invention provides centrifugal rotors for delivering a liquid, typically a biological sample such as diluted plasma, to an unvented chamber in the rotor through an unmodified inlet channel. The unvented chamber is typically a cuvette comprising reagents necessary for analysis of a biological sample. The unmodified inlet channels are sized such that, as the rotor spins, gas escapes from the chamber through the inlet channel as the liquid enters the chamber through the inlet channel. The primary feature which allows the air to escape from the unvented chamber is that the cross sectional area of the inlet channel is greater than the cross sectional area of the liquid flowing through it.Type: GrantFiled: September 1, 1993Date of Patent: January 7, 1997Assignee: Abaxis, Inc.Inventor: Carol T. Schembri
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Patent number: 5590052Abstract: The present invention provides various methods for detecting errors in a blood analysis system. The system includes a blood analyzer and a molded plastic rotor with a series of chambers and capillary channels through which blood is processed and distributed to cuvettes which contain lyophilized reagents. The rotor is placed in the analyzer which spins the rotor, and an optical system reads the cuvettes as light is flashed through the cuvettes.Type: GrantFiled: April 14, 1994Date of Patent: December 31, 1996Assignee: Abaxis, Inc.Inventors: Anne R. Kopf-Sill, Steven N. Buhl, Glenda L. Choate, Lloyd A. Schick, Robert E. Nagle, Jenq C. Chang, Daniel Bernstein, Wayne A. Britt
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Patent number: 5518930Abstract: The present invention provides centrifugal rotors for delivering a liquid, typically a biological sample such as diluted plasma, to a plurality of cuvettes in the rotor. The cuvettes are positioned radially inward of an annulate manifold and are connected to the manifold through a plurality of inlet channels. The liquid is introduced in one end of the manifold and, as the rotor spins, the liquid fills the manifold from the radially outward edge inward. After, the manifold fills, the liquid flows radially inward through the inlet channels into the chambers. The design allows the simultaneous filling of the cuvettes. The inlet channels may also be sized such that as liquid enters the cuvettes, gas escapes through the inlet channel.Type: GrantFiled: January 27, 1995Date of Patent: May 21, 1996Assignee: Abaxis, Inc.Inventor: Tammy L. Burd