Abstract: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.
Abstract: The present invention relates to analytical testing devices comprising segmented fluidics and methods for assaying coagulation in a fluid sample received within the segmented fluidics. For example, the present invention may be directed to sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a first flow restrictor region, a second reagent, and a second sensor region. The sample analysis cartridge further includes a pump configured to independently mix the first segment in the second conduit and the second segment in the third conduit, and independently position the first segment over the first sensor region and position the second segment over the second sensor region.
Type:
Application
Filed:
July 13, 2018
Publication date:
November 8, 2018
Applicant:
Abbott Point of Care Inc.
Inventors:
Katrina Petronilla Di Tullio, Jay Kendall Taylor, John Lewis Emerson Campbell, Caglar Elbuken, Shelia Diane Ball, Noam Saul Lightstone
Abstract: The present invention relates to analytical testing devices comprising fluidic junctions and methods for assaying coagulation in a fluid sample received within the fluidic junctions. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a second reagent, a second sensor region, and a second fluidic lock valve. The sample analysis cartridge further includes a pump configured to push the first segment over the first sensor region to the first fluidic lock valve, and push the second segment over the second sensor region to the second fluidic lock valve.
Type:
Application
Filed:
July 13, 2018
Publication date:
November 8, 2018
Applicant:
Abbott Point of Care Inc.
Inventors:
Katrina Petronilla Di Tullio, Jay Kendall Taylor, Niko Daniel Lee-Yow, Sheila Diane Ball, John Lewis Emerson Campbell
Abstract: The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve.
Type:
Grant
Filed:
September 25, 2015
Date of Patent:
October 30, 2018
Assignee:
Abbott Point of Care Inc.
Inventors:
Katrina Petronilla Di Tullio, Jay Kendall Taylor, Niko Daniel Lee-Yow, Sheila Diane Ball
Abstract: A method and apparatus for identifying platelets within a whole blood sample. The method includes the steps of: a) adding at least one colorant to the whole blood sample, which colorant is operable to tag platelets; b) disposing the blood sample into a chamber defined by at least one transparent panel; c) imaging at least a portion of the sample quiescently residing within the chamber to create one or more images; and d) identifying one or more platelets within the sample using an analyzer adapted to identify the platelets based on quantitatively determinable features within the image using a analyzer, which quantitatively determinable features include intensity differences.
Abstract: In one embodiment, the invention is to a sample metering device, comprising a sample holding chamber oriented between a sample entry port and a sample extraction unit, wherein a portion of said extraction unit defines a metered volume of a sample. A diluent may be transported over and/or through the extraction unit to form a diluted sample for sample analysis. In another embodiment, the invention is to an apparatus and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature, capable of being used in the point-of-care diagnostic field is provided. The devices and methods of the invention preferably are well-suited for high range sample dilution.
Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
Type:
Application
Filed:
April 16, 2018
Publication date:
August 23, 2018
Applicant:
Abbott Point of Care Inc.
Inventors:
Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Christopher Fetters
Abstract: The present invention relates to analytical testing devices comprising segmented fluidics and methods for assaying coagulation in a fluid sample received within the segmented fluidics. For example, the present invention may be directed to sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a first flow restrictor region, a second reagent, and a second sensor region. The sample analysis cartridge further includes a pump configured to independently mix the first segment in the second conduit and the second segment in the third conduit, and independently position the first segment over the first sensor region and position the second segment over the second sensor region.
Type:
Grant
Filed:
September 25, 2015
Date of Patent:
August 14, 2018
Assignee:
Abbott Point of Care Inc.
Inventors:
Katrina Petronilla Di Tullio, Jay Kendall Taylor, John Lewis Emerson Campbell, Caglar Elbuken, Shelia Diane Ball, Noam Saul Lightstone
Abstract: The present invention relates to analytical testing devices comprising fluidic junctions and methods for assaying coagulation in a fluid sample received within the fluidic junctions. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a second reagent, a second sensor region, and a second fluidic lock valve. The sample analysis cartridge further includes a pump configured to push the first segment over the first sensor region to the first fluidic lock valve, and push the second segment over the second sensor region to the second fluidic lock valve.
Type:
Grant
Filed:
September 25, 2015
Date of Patent:
August 14, 2018
Assignee:
Abbott Point of Care Inc.
Inventors:
Katrina Petronilla Di Tullio, Jay Kendall Taylor, Niko Daniel Lee-Yow, Sheila Diane Ball, John Lewis Emerson Campbell
Abstract: A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.
Abstract: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.
Type:
Grant
Filed:
March 31, 2016
Date of Patent:
August 14, 2018
Assignee:
Abbott Point of Care Inc.
Inventors:
Cary James Miller, John Lewis Emerson Campbell
Abstract: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.
Abstract: A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory.
Type:
Grant
Filed:
August 6, 2014
Date of Patent:
July 17, 2018
Assignee:
Abbott Point of Care Inc.
Inventors:
Jody Ann Tirinato, Michael P. Zelin, Paul Andrew Gibson, Lyudmila Zaltsman, Graham Davis
Abstract: The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.
Type:
Application
Filed:
March 6, 2018
Publication date:
July 12, 2018
Applicant:
Abbott Point of Care Inc.
Inventors:
Gordon Bruce Collier, Paul Willis Johns, Smitha RK Sutrala, Dan Wang, Katrina Petronilla Di Tullio
Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
Type:
Application
Filed:
February 28, 2018
Publication date:
July 5, 2018
Applicant:
Abbott Point of Care Inc.
Inventors:
Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Tian-Xian Zhao, Paul Glavina
Abstract: The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.
Type:
Application
Filed:
January 25, 2018
Publication date:
June 14, 2018
Applicant:
Abbott Point of Care Inc.
Inventors:
Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha RK Sutrala, Eric Hong, Sheila Diane Ball
Abstract: A biological fluid sample analysis cartridge is provided. The cartridge includes a housing, a fluid module, and an analysis chamber. The fluid module includes a sample acquisition port and an initial channel, and is connected to the housing. The initial channel is sized to draw fluid sample by capillary force, and is in fluid communication with the acquisition port. The initial channel is fixedly positioned relative to the acquisition port such that at least a portion of a fluid sample disposed within the acquisition port will draw into the initial channel. The analysis chamber is connected to the housing, and is in fluid communication with the initial channel.
Type:
Grant
Filed:
January 31, 2017
Date of Patent:
June 12, 2018
Assignee:
Abbott Point of Care, Inc.
Inventors:
John A. Verrant, John N. Blum, Vu Phan, Kaushal K. Verma, Elise G. Edson
Abstract: The invention relates to compositions and methods for the immunoassay of an analyte of interest. The analyte is detected in an immunoassay using three or more antibodies, where in each antibody specifically binds to a different epitope on the analyte. When the analyte of interest in a clinical marker for an acute disease, the detection of the analyte by immunoassay is a diagnosis of the occurrence of the disease.
Type:
Grant
Filed:
January 13, 2016
Date of Patent:
June 12, 2018
Assignee:
Abbott Point of Care Inc.
Inventors:
John Lewis Emerson Campbell, Pamela Anne Frank, Meghan Elizabeth Hawkes, Shannon Reishma Lobin, Cary James Miller, Zhen Yang
Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
Type:
Application
Filed:
January 23, 2018
Publication date:
June 7, 2018
Applicant:
Abbott Point of Care Inc.
Inventors:
Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis
Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
Type:
Application
Filed:
January 11, 2018
Publication date:
May 17, 2018
Applicant:
Abbott Point of Care Inc.
Inventors:
Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Cary Miller