Abstract: Electrochemical devices with metal casings have been considered incompatible with nuclear magnetic resonance (NMR) spectroscopy because the oscillating magnetic fields (“rf fields”) responsible for excitation and detection of NMR active nuclei do not penetrate metals. According to the present invention, rf fields can still efficiently penetrate into nonmetallic layers of electrochemical cells (such as a coin cell battery configuration) provided the magnetic field is oriented tangentially to the electrochemical cell electrodes in a “skimming” orientation. As an example, noninvasive high field in situ 7Li and 19F NMR of an unmodified commercial off-the-shelf rechargeable coin cell was demonstrated using a traditional external NMR coil setup. The in operando NMR measurements revealed that irreversible physical changes accumulate at the anode during electrochemical cycling.

Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Abstract: A magnetic field correction system including apparatus and method for adjusting a magnetic field is provided, for example to enhance the uniformity of the field in a Nuclear Magnetic Resonance (NMR) operation. The system is of an electronic “shimming” type. The layout of the wires of the shim coils is simplified to conserve working space inside a magnet, such as an NMR magnet. The complexity of the shimming system is removed from the coils and transferred to the current controlling electronics. The current paths do not require cross-over points, and groups of parallel wires are arranged such that the wire groups have axes with different directional orientations. By deploying such shim wire groups in differently oriented axial directions, a compact shimming apparatus is provided for generating a controllable corrective magnetic field for adjusting a main original field, such as to enhance the homogeneity of the main field.

Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Abstract: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use. In certain embodiments, the invention provides a module including a microcoil possessing an inner diameter of between 25 microns and 550 microns, a conduit disposed proximate to the microcoil, in which the conduit is in fluid communication with a sample reservoir, an affinity column in fluid communication with the conduit and the sample reservoir, and a connector for connecting the module to a magnetic resonance detector.

Abstract: A method and apparatus for tuning and matching extremely small sample coils with very low inductance for use in magnetic resonance experiments conducted at low frequencies. A circuit is disclosed that is appropriate for performing measurements in fields where magnetic resonance is beneficially utilized. The circuit has a microcoil, an adjustable tuning capacitance, and added inductance in the form of a tuning inductor. The microcoil is an electrical coil having an inductance of about 25 nanohenries (nH) or less. Because additional inductance is purposefully added, the capacitance required for resonance and apparatus function is proportionally and helpfully reduced. The apparatus and method permit the resonant circuit and the magnet to be made extremely small, which is crucial for new applications in portable magnetic resonance imaging, for example.

Abstract: The present invention provides resonance circuits, detection devices incorporating such circuits, and methods for their design, construction, and use.

Abstract: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use.

Abstract: The present invention provides resonance circuits, detection devices incorporating such circuits, and methods for their design, construction, and use.

Abstract: A method and apparatus for tuning and matching extremely small sample coils with very low inductance for use in magnetic resonance experiments conducted at low frequencies. A circuit is disclosed that is appropriate for performing measurements in fields where magnetic resonance is beneficially utilized. The circuit has a microcoil, an adjustable tuning capacitance, and added inductance in the form of a tuning inductor. The microcoil is an electrical coil having an inductance of about 25 nanohenries (nH) or less. Because additional inductance is purposefully added, the capacitance required for resonance and apparatus function is proportionally and helpfully reduced. The apparatus and method permit the resonant circuit and the magnet to be made extremely small, which is crucial for new applications in portable magnetic resonance imaging, for example.