Patents Assigned to Accelerate Diagnostics, Inc.
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Patent number: 11940757Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.Type: GrantFiled: June 22, 2021Date of Patent: March 26, 2024Assignee: Accelerate Diagnostics, Inc.Inventor: Oleg Gusyatin
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Patent number: 11603550Abstract: Systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance are disclosed.Type: GrantFiled: April 11, 2017Date of Patent: March 14, 2023Assignee: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Publication number: 20220162664Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: June 30, 2021Publication date: May 26, 2022Applicant: Accelerate Diagnostics, Inc.Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote
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Publication number: 20220099671Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: May 12, 2021Publication date: March 31, 2022Applicant: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20220066390Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.Type: ApplicationFiled: September 13, 2021Publication date: March 3, 2022Applicant: Accelerate Diagnostics, Inc.Inventor: Oleg Gusyatin
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Publication number: 20220011722Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.Type: ApplicationFiled: June 22, 2021Publication date: January 13, 2022Applicant: Accelerate Diagnostics, Inc.Inventor: Oleg Gusyatin
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Patent number: 11085064Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: GrantFiled: February 28, 2020Date of Patent: August 10, 2021Assignee: Accelerate Diagnostics, Inc.Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote
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Patent number: 11079719Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.Type: GrantFiled: July 5, 2018Date of Patent: August 3, 2021Assignee: Accelerate Diagnostics, Inc.Inventor: Oleg Gusyatin
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Patent number: 11054420Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: November 30, 2017Date of Patent: July 6, 2021Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20200370086Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: February 28, 2020Publication date: November 26, 2020Applicant: Accelerate Diagnostics, Inc.Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote
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Patent number: 10619180Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: GrantFiled: March 8, 2019Date of Patent: April 14, 2020Assignee: Accelerate Diagnostics, Inc.Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote
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Publication number: 20190203252Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: March 8, 2019Publication date: July 4, 2019Applicant: Accelerate Diagnostics, Inc.Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote
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Patent number: 10273521Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: GrantFiled: December 20, 2017Date of Patent: April 30, 2019Assignee: Accelerate Diagnostics, Inc.Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote
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Patent number: 10253355Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.Type: GrantFiled: October 3, 2016Date of Patent: April 9, 2019Assignee: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Patent number: 10254204Abstract: Methods and systems for purifying one or more microbial cells and/or viruses from a biological sample are provided. The biological sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the microbial cells and/or viruses in the well. The microbial cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the microbial cells and/or viruses are retained in the well by embedding in the medium. The medium including the embedded microbial cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: GrantFiled: May 3, 2017Date of Patent: April 9, 2019Assignee: Accelerate Diagnostics, Inc.Inventors: Landon Prisbrey, Elise Blackmore, Kenneth R. Hance, Steven W. Metzger, Kevin Marshall
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Patent number: 10202597Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: GrantFiled: August 12, 2016Date of Patent: February 12, 2019Assignee: Accelerate Diagnostics, Inc.Inventors: Steven W. Metzger, Kenneth Robert Hance
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Publication number: 20190011882Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.Type: ApplicationFiled: July 5, 2018Publication date: January 10, 2019Applicant: Accelerate Diagnostics, Inc.Inventor: Oleg Gusyatin
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Publication number: 20180291419Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: June 13, 2018Publication date: October 11, 2018Applicant: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt, Phillip C. Halbert, Solene Bourgeois
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Patent number: 10023895Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: GrantFiled: March 30, 2016Date of Patent: July 17, 2018Assignee: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Publication number: 20180135093Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: December 20, 2017Publication date: May 17, 2018Applicant: Accelerate Diagnostics, Inc.Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote