Patents Assigned to Adam Mickiewicz University
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Patent number: 11006632Abstract: Disclosed herein are amide 7-carboxybenzo[1,2,3]thiadiazoles and derivatives thereof having a general Formula I, as described herein. Combinations and compositions of these compounds are also disclosed. The compounds and compositions can be used as a plant stimulant. For example, the compounds compositions can be used to regulate the plant's growth, regulate the plant's metabolic processes, regulate the plant's physiological processes, prevent against effects of biotic stress in the plant, or prevent against effects of abiotic stress in the plant. In some embodiments, the composition can provide multiple disease resistance to plants infected with a fungus, virus, or bacteria.Type: GrantFiled: July 27, 2016Date of Patent: May 18, 2021Assignee: Adam Mickiewicz University FoundationInventors: Marcin Śmiglak, Henryk Pospieszny, Rafal Kukawka, Piotr Lewandowski, Olga Stolarska, Hieronim Maciejewski
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Publication number: 20190144636Abstract: Mixtures of salts to dissolve cellulose. The present invention refers to a composition based in a eutectic mixture of imidazolium salts and natural biopolymers, in particular cellulose, its manufacturing process and method of use to obtain foils or films. The composition is based in a eutectic mixture of imidazolium salts with 0.1 to 50 wt % of biomass.Type: ApplicationFiled: June 29, 2017Publication date: May 16, 2019Applicants: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, ADAM MICKIEWICZ UNIVERSITY FOUNDATIONInventors: Hector RODRIGUEZ MARTINEZ, Ana Maria SOTO CAMPOS, Olga STOLARSKA, Marcin SMIGLAK, Anna PAWLOWSKA
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Patent number: 9605017Abstract: The subject matter of the invention is novel 2?,5?-dideoxy-5-fluorouridine derivatives of general formula 1. wherein R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. In a second aspect, the subject matter of the invention is a process for the manufacture of 2?,5?-dideoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2?,5?-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.Type: GrantFiled: March 4, 2014Date of Patent: March 28, 2017Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Lech Celewicz, Karol Kacprzak, Marta Lewandowska, Piotr Ruszkowski, Natalia Kleczewska
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Patent number: 9518069Abstract: New (triorganosilyl)alkynes and their derivatives having general formula R1—C?C—Z are provided along with methods for the preparation of (triorganosilyl)alkynes and their derivatives having the general formula R1—C?C—Z. The methods may include silylative coupling of terminal alkynes with halogenotriorganosilanes in the presence of an iridium catalyst and a tertiary amine.Type: GrantFiled: July 10, 2015Date of Patent: December 13, 2016Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Ireneusz Kownacki, Bogdan Marciniec, Beata Dudziec, Agnieszka Kownacka, Mariusz Majchrzak, Mateusz Szulc, Bartosz Orwat
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Publication number: 20160244473Abstract: The subject matter of the invention is novel 2?,5?-dideoxy-5-fluorouridine derivatives of general formula 1. wherein R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. In a second aspect, the subject matter of the invention is a process for the manufacture of 2?,5?-dideoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2?,5?-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.Type: ApplicationFiled: March 4, 2014Publication date: August 25, 2016Applicant: ADAM MICKIEWICZ UNIVERSITYInventors: Lech CELEWICZ, Karol KACPRZAK, Marta LEWANDOWSKA, Piotr RUSZKOWSKI, Natalia KLECZEWSKA
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Patent number: 9388209Abstract: 2?,3?-dideoxy-5-fluorouridine derivatives have general formula 1: wherein: R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. A process for the manufacture of 2?,3?-dideoxy-5-fluorouridine derivatives of general formula 1 and application of 2?,3?-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer and hepatic cancer are also indicated.Type: GrantFiled: March 4, 2014Date of Patent: July 12, 2016Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Lech Celewicz, Karol Kacprzak, Dagmara Baraniak, Marta Lewandowska, Piotr Ruszkowski
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Patent number: 9301956Abstract: 9-O-propargyl ethers of cinchona alkaloids of general formula represented by formula 1 wherein respective ethers have the following absolute configuration at C-8 and C-9 atoms: (8R,9S)-cinchonine configuration or (8R,9R)-9-epicinchonine configuration are useful in treatments of at least one of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.Type: GrantFiled: March 4, 2014Date of Patent: April 5, 2016Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Lech Celewicz, Karol Kacprzak, Piotr Ruszkowski
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Patent number: 9260468Abstract: The subject matter of the invention is novel 2,3?-anhydro-2?-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3?-anhydro-2?-deoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2,3?-anhydro-2?-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.Type: GrantFiled: August 22, 2014Date of Patent: February 16, 2016Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Lech Celewicz, Karol Kacprzak, Piotr Ruszkowski, Marta Lewandowska
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Patent number: 9255112Abstract: (Dimethylvinylgermoxy)heptasubstituted silsesquioxanes of the formula 1, in which the substituents R are equal to one another and represent: a linear or branched C2 to C8 alkyl group; a cyclopentyl or cyclohexyl group; a phenyl group; and the method of their synthesis.Type: GrantFiled: April 2, 2015Date of Patent: February 9, 2016Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Dawid Frąckowiak, Patrycja Żak, Bogdan Marciniec
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Patent number: 9249167Abstract: A new cage monovinylgermasilsesquioxanes of the general formula 1, in which R1 are the same and represent a C1 to C6 alkyl group or a cyclopentyl or cyclohexyl group or a phenyl group. The invention also relates to the method of synthesis of cage monovinylgermasilsesquioxanes of the general formula 1.Type: GrantFiled: April 2, 2015Date of Patent: February 2, 2016Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Dawid Frackowiak, Patrycja Żak, Bogdan Marciniec
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Publication number: 20160024133Abstract: The subject matter of the invention is novel 2,3?-anhydro-2?-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1 -difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3-anhydro-2?-deoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2,3?-anhydro-2?-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.Type: ApplicationFiled: August 22, 2014Publication date: January 28, 2016Applicant: Adam Mickiewicz UniversityInventors: Lech CELEWICZ, Karol KACPRZAK, Piotr RUSZKOWSKI, Marta LEWANDOWSKA
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Patent number: 9243008Abstract: The invention relates to new functionalized unsaturated derivatives of (dimethylvinylgermoxy)heptasubstituted silsesquioxanes of the general formula 1, and the method in which: R are the same and represent linear and branched C2 to C8 alkyl groups, or cyclopentyl and cyclohexyl groups, or phenyl groups R? represents an unsubstituted aryl group containing between 1 and 2 rings or an aryl group substituted in any position in the ring. The invention also relates to the method of synthesis of functionalized unsaturated derivatives of (dimethylvinylgermoxy)heptasubstituted silsesquioxanes.Type: GrantFiled: April 2, 2015Date of Patent: January 26, 2016Assignee: Adam Mickiewicz UniversityInventors: Dawid Frąckowiak, Patrycja Żak, Bogdan Marciniec
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Patent number: 9150596Abstract: The subject of the invention are new functionalized unsaturated double-decker derivatives of divinylsilsesquioxanes of the general formula 1. In the formula, R1 are the same and stand for an aryl group containing from 1 to 2 rings, R2 are the same and stand for an alkyl group containing carbon atoms from C1 to C2, substituted or unsubstituted aryl group containing from 1 to 2 rings, R3 are the same and stand for a substituted or unsubstituted aryl group containing from 1 to 2 rings or a group of the formula —R4-R5—, where R4 stands for an alkyl group containing carbon atoms from C1 to C3, while R5 stands for aryl group containing from 1 to 2 rings.Type: GrantFiled: March 6, 2015Date of Patent: October 6, 2015Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Marciniec Bogdan, Dudziec Beata, Zak Patrycja
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Patent number: 9108994Abstract: The present invention relates to new (triorganosilyl)alkynes and their derivatives having general formula 1 R1—C?C—Z (I) In its second aspect, this invention relates to a new selective method for the preparation of new and conventional (triorganosilyl)alkynes and their derivatives having the general formula 1, by the silylative coupling of terminal alkynes with halogenotriorganosilanes in the presence of an iridium catalyst and a tertiary amine.Type: GrantFiled: December 29, 2011Date of Patent: August 18, 2015Assignee: ADAM MICKIEWICZ UNIVERSITYInventors: Ireneusz Kownacki, Bogdan Marciniec, Beata Dudziec, Agnieszka Kownacka, Mariusz Majchrzak, Mateusz Szulc, Bartosz Orwat
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Patent number: 9018400Abstract: A new functionalized polyhedral octavinylsilsesquioxanes having the general formula 1, in which R1 denotes: (1) any aryl group other than a non-substituted phenyl or a phenyl substituted in position four with a halogen or the groups-trimethylsilylethynyl, 4,4,5,5-tetramethyl-1,3-dioxaborolane-2-yl, 3,4-dimethoxyphenyl, 3?,5?-bis(methoxycarbonyl)phenyl or benzo[d][1,3]-dioxol-5-yl; (2) any heteroaryl group; or (3) groups including coupled aromatic rings. Additionally, a method to obtain new and known functionalized polyhedral octavinylsilsesquioxanes having the general formula 1, by the silylating coupling of octavinylsilsesquioxane with olefins in the presence of a ruthenium complex catalyst.Type: GrantFiled: August 4, 2011Date of Patent: April 28, 2015Assignee: Adam Mickiewicz UniversityInventors: Bogdan Marciniec, Cezary Pietraszuk, Mariusz Majchrzak, Patrycja Zak
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Patent number: 8841473Abstract: The subject of invention is the method of synthesis of fluorosilicone co-polymers of arbitrary topology and general formula 1 in which among others if A stands for CH—O(CH2)m(CF2)nCF2H group, then the method is based on hydrosilylation reaction of appropriate fluoroalkyl-allyl ether with polyhydrosiloxanes containing at least one Si—H group, catalyzed by siloxide rhodium complex. If A stands for in which Z stands for divalent group either then the method is based on the reaction of nucleophilic opening of oxirane ring in appropriate epoxyfunctional co-polysiloxanes, in acidic environment.Type: GrantFiled: August 16, 2010Date of Patent: September 23, 2014Assignee: Adam Mickiewicz UniversityInventors: Bogdan Marciniec, Hieronim Maciejewski, Izabela Dabek, Joanna Karasiewicz
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Patent number: 8816117Abstract: The subject of the invention is the method of synthesis of fluoracarbofunctional cage silsesquioxanes of the general formula in which•R1 stands for HCF2(CF2)n(CH2)mO(CH2)3Si(CH3)2O or HCF2(CF2)n(CH2)mO(CH2)3 group in which n=1-12, m=1-4;•R2, R3, R4, R5, R6, R7, R8 can be the same as R1 or different from it and stand all either for the (C1-C25) alkyl group or any aryl group, based on hydrosilylation of fluoroalkyl-allyl ether with an appropriate hydrogen-silsesquioxane in the presence of siloxide rhodium complex [{Rh(OSiMe3)(cod)}2] as a catalyst.Type: GrantFiled: August 16, 2010Date of Patent: August 26, 2014Assignee: Adam Mickiewicz UniversityInventors: Bogdan Marciniec, Hieronim Maciejewski, Michal Dutkiewicz
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Patent number: 8680310Abstract: New (E)-styryl-alkynylsubstituted silicon compounds having the generalized formula 1 and A new method of obtaining (E)-styryl-alkynylsubstituted silicon compounds having the generalized formula 1. A denotes: phenylmethylsilyl, 1,4-bis(dimethylsilyl)benzene, 1,2-bis(dimethylsilyl)ethane, 1,1,3,3-tetramethyldisilazane, 1,1,3,3-tetramethyldisiloxane, R? denotes: tri(isopropyl)silyl, 1-pentyl, 2-(trimethylsiloxy)-2-butyl, 1-(trimethylsiloxy)-1-cyclohexyl, triethylgermyl, R? denotes: H or Cl and when A denotes phenylmethylsilyl then R? denotes also methyl or a methoxy group. A method of obtaining (E)-styrylalkynylsubstituted silicon compounds having the generalized formula 1 where A, R? and R? denote the same as stated above by way of a silylative coupling reaction between a suitable substituted styrene and a suitable vinyl-alkynylsubstituted silicon compound in the presence of a ruthenium(II) complex as catalyst.Type: GrantFiled: August 20, 2010Date of Patent: March 25, 2014Assignee: Adam Mickiewicz UniversityInventors: Bogdan Marciniec, Beata Dudziec, Monika Rzonsowska
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Publication number: 20140005427Abstract: The present invention relates to new (triorganosilyl)alkynes and their derivatives having general formula 1 R1—C?C—Z (I) In its second aspect, this invention relates to a new selective method for the preparation of new and conventional (triorganosilyl)alkynes and their derivatives having the general formula 1, by the silylative coupling of terminal alkynes with halogenotriorganosilanes in the presence of an iridium catalyst and a tertiary amine.Type: ApplicationFiled: December 29, 2011Publication date: January 2, 2014Applicant: ADAM MICKIEWICZ UNIVERSITYInventors: Ireneusz Kownacki, Bogdan Marciniec, Beata Dudziec, Agnieszka Kownacka, Mariusz Majchrzak, Mateusz Szulc, Bartosz Orwat
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Publication number: 20130102793Abstract: A new functionalized polyhedral octavinylsilsesquioxanes having the general formula 1, in which R1 denotes: (1) any aryl group other than a non-substituted phenyl or a phenyl substituted in position four with a halogen or the groups-trimethylsilylethynyl, 4,4,5,5-tetramethyl-1,3-dioxaborolane-2-yl, 3 ,4-dimethoxyphenyl, 3?, 5?-bis(methoxycarbonyl)phenyl or benzo[d][1,3]-dioxol-5-yl; (2) any heteroaryl group; or (3) groups including coupled aromatic rings. Additionally, a method to obtain new and known functionalized polyhedral octavinylsilsesquioxanes having the general formula 1, by the silylating coupling of octavinylsilsesquioxane with olefins in the presence of a ruthenium complex catalyst.Type: ApplicationFiled: August 4, 2011Publication date: April 25, 2013Applicant: ADAM MICKIEWICZ UNIVERSITYInventors: Bogdan Marciniec, Cezary Pietraszuk, Mariusz Majchrzak, Patrycja Zak