Abstract: The invention relates to a product for the release of highly lipophilic physiologically active substances, comprising a core and a coating on top of the core, the coating comprising one or more highly lipophilic physiologically active substances, one or more water-soluble film-forming agents and, relative to the weight of all components, not more than 20 wt % of other auxiliary substances.

Abstract: The invention relates to a solid dosage form that comprises a matrix with one or more highly lipophilic physiologically active substances, one or more water-soluble binders and, relative to the weight of all components, not more than 20 wt % of other auxiliary substances, wherein a physiologically active substance being highly lipophilic if it has a log P of 4 or more.

Abstract: Pharmaceutical formulation in the form of a solid dispersion, wherein the solid dispersion comprises in admixture a cannabinoid, an amphiphilic block copolymer as a solubilizer and a water-soluble film former. A method for preparing a formulation as defined, wherein the method comprises the following steps: (i) preparing a liquid composition comprising the cannabinoid, the amphiphilic block copolymer and a solvent capable of at least partially dissolving the cannabinoid and the amphiphilic block copolymer; (ii) introducing the liquid composition into a fluid bed granulator; (iii) removing solvent to obtain a solid dispersion in particulate form; and (iv) recovering the solid dispersion in particulate form from the fluid bed granulator.

Abstract: A conveyor assembly for raising and feeding debris such as fallen branches from an orchard floor to a processor such as a wood-chipper is provided. The conveyor assembly comprises a body including a floor having a leading end for location adjacent ground level and a trailing end for location above the leading end in use. A ground contact arrangement is located toward the leading end extends beneath the leading end to thereby raise the leading end above ground level. A powered leading feed roller is disposed adjacent the leading end of the floor to direct members from ground on to the floor. A powered, primary infeed roller is located rearward the leading infeed roller and is arranged to move toward and away from the floor to accommodate members between said roller and the floor and urge the members, such as fallen branches rearward for entry into an inlet of the wood-chipper.

Abstract: Disclosed is a diagnostic kit for diagnosis of breast cancer, the kit detecting the breast cancer tumor marker CA 15-3 in a biological sample, wherein the kit can diagnose the presence or absence of the breast cancer tumor marker CA 15-3 from test results conveniently and promptly without any special test equipment by using rapid immunochromatography using lateral flow assay, and thus has advantages of ease, economical efficiency, and speedy reading of test results.

Abstract: Uses and formulations of cannabinoids, in particular of cannabidiol, are provided. The cannabinoids, in particular cannabidiol, are used for the treatment of patients suffering from inflammatory conditions associated with autoimmune diseases, chronic inflammatory diseases and inflammatory conditions in connection with infections, including cytokine release syndrome (CRS). Formulations are especially for oral administration of cannabinoids, in particular of cannabidiol. These formulations are useful for treating patients suffering from conditions as referred to above.

Abstract: Uses and formulations of cannabinoids, in particular of cannabidiol, are provided. The cannabinoids, in particular cannabidiol, are used for the treatment of patients suffering from COVID-19, a disease caused by the coronavirus SARS-Cov-2. Formulations are especially for oral administration of cannabinoids, in particular of cannabidiol. These formulations are useful for treating patients suffering from COVID-19.

Abstract: Uses and formulations of cannabinoids, in particular of cannabidiol, are provided. The cannabinoids, in particular cannabidiol, are used for the treatment of patients suffering from COVID-19, a disease caused by the coronavirus SARS-Cov-2. Formulations are especially for oral administration of cannabinoids, in particular of cannabidiol. These formulations are useful for treating patients suffering from COVID-19.

Abstract: Uses and formulations of cannabinoids, in particular of cannabidiol, are provided. The cannabinoids, in particular cannabidiol, are used for the treatment of patients suffering from inflammatory conditions associated with autoimmune diseases, chronic inflammatory diseases and inflammatory conditions in connection with infections, including cytokine release syndrome (CRS). Formulations are especially for oral administration of cannabinoids, in particular of cannabidiol. These formulations are useful for treating patients suffering from conditions as referred to above.

Abstract: A process for the continuous production of an active ingredient granulate is provided, which comprises the following steps: (a) preparing a spray composition by dissolving or dispersing an active ingredient and optionally one or more excipients in a liquid; (b) providing solid particles in a process space; (c) introducing droplets of the spray composition into an injection zone of the process space in which the liquid evaporates; (d) repeated guiding of the solid particles past the sprayed droplets in the process space with the aid of a process gas jet, so that at least a portion of the droplets, which may have already lost part of the liquid contained, comes into contact with solid particles and larger solid particles are formed through agglomeration; (e) removing the active ingredient granulate from the process space in the form of solid particles, wherein the active ingredient comprises metformin or an acid addition salt of metformin, in particular metformin hydrochloride.

Abstract: A method for the continuous production of an active ingredient granulate is provided, which comprises the following steps: (a) preparing a spray composition by dissolving or dispersing an active ingredient and optionally one or more excipients in a liquid; (b) providing solid particles in a process space; (c) introducing droplets of the spray composition into an injection zone of the process space in which the liquid evaporates; (d) repeatedly guiding the solid particles back past the sprayed droplets in the process space with the aid of a process gas jet, so that at least a portion of the droplets, which may have already lost part of the liquid contained, comes into contact with solid particles and larger solid particles are formed through agglomeration; (e) removing the active ingredient granulate from the process space in the form of solid particles, wherein the active ingredient in the form used has a Hausner factor of 1.19 or greater.

Abstract: A pharmaceutical pellet is disclosed, comprising a spherical core containing active ingredient with a smooth surface and a coating on the core which controls the release of the active ingredient in a pH-independent manner. With such a pellet the release of the active ingredient can follow a profile with a lag phase of 60 minutes to 840 minutes, a proportion of 5 wt. % or less of the active ingredient being released during the lag phase. The active ingredient can furthermore be released from the pellet with a profile such that after the lag phase the release of the active ingredient amounts to between 3 and 25 wt. % per hour.

Abstract: A conveyor assembly for raising and feeding debris such as fallen branches from an orchard floor to a processor such as a wood-chipper is provided. The conveyor assembly comprises a body including a floor having a leading end for location adjacent ground level and a trailing end for location above the leading end in use. A ground contact arrangement is located toward the leading end extends beneath the leading end to thereby raise the leading end above ground level. A powered leading feed roller is disposed adjacent the leading end of the floor to direct members from ground on to the floor. A powered, primary infeed roller is located rearward the leading infeed roller and is arranged to move toward and away from the floor to accommodate members between said roller and the floor and urge the members, such as fallen branches rearward for entry into an inlet of the wood-chipper.

Abstract: The invention relates to a method for the production of carrier pellets for pharmaceutical active substances. Likewise, the invention relates to such carrier pellets and also to pharmaceutical formulations containing these. The carrier pellets according to the invention are used for transporting and releasing pharmaceutical active substances, in particular in the human body.

Abstract: Provided is an acid-pickling additive for a surface oxide scale of a stainless steel material, a preparation method thereof and an acid-pickling method. The acid-pickling additive consists of 1 to 10 parts by weight of an alcohol amine compound, 0.1 to 5 parts by weight of a metal complex ligand, 0 to 10 parts by weight of a nitrogen-containing organic cyclic compound, 0 to 3 parts by weight of an alcohol compound, 0 to 3 parts by weight of a plant extract, and 1 to 2 parts by weight of water. This acid-pickling additive can solve the problems of high energy consumption, environmental pollution, and high cost in the existing method for removing an oxide scale of a stainless steel.

Abstract: Process accuracy and throughput in a system for processing timber and lumber with a circular gang saw can be improved by measuring a sawing force and a guide friction force near an end of one or more saw arbors and incorporating the force measurement into a process control system to adjust the workpiece feed speed (or other process parameters) to achieve better results.

Abstract: A method of using a central computer that is communicatively connectable to a first control computer and configured to dynamically allocate and transmit unique codes from a server to a first printing machine, having a first rate of printing.

Abstract: A process for killing a well includes drilling a first relief well and a second relief well toward the well, affixing a first relief well injection spool to the first relief well and affixing a second relief well injection spool to the second relief well, connecting a flowline to a flow channel of the first and second relief well injection spools, connecting a pipe to the first relief well injection spool so as to extend to a surface location, connecting a second pipe to the second relief well injection spool so as to extend to another surface location, and flowing a kill fluid through the second pipe such that the kill fluid flows through the flowline and into the flow channel of the first relief well injection spool so as to pass into the first relief well and into the well.

Abstract: A relief well injection spool for use in killing a well has a body with a pair of inlets opening to a bore on an interior of the body, a ram body cooperative with the bore of the body so as to selectively open and close the bore, an upper connector affixed to the body and adapted to connect the body to a lower end of a blowout preventer, and a wellhead connector affixed to a lower end of the body. Each of the pair of inlets has a valve cooperative therewith. The upper connector opens to the bore of the body. The wellhead connector is adapted to connect to a relief well wellhead. The wellhead connector also opens to the bore of the body. A floating vessel can be provided so as to deliver a kill fluid into at least one of the pair of inlets.